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Superior vena cava syndrome and colon carcinoma: a report of a multifactorial association.

Espírito Santo J, Coutinho I, Pimentel A, Garcia R, Marques Dos Santos R - Case Rep Oncol Med (2015)

Bottom Line: Cancer is associated with an increased risk of thromboembolism that varies according to patient-, tumor-, and treatment-related factors.The authors present a case of a 58-year-old male with an infrequent presentation of an unknown colon carcinoma, who has never had any symptom until he was hospitalized with the diagnosis of superior vena cava syndrome and pulmonary thromboembolism.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine Department A, University Hospital Center of Coimbra, 3000-075 Coimbra, Portugal.

ABSTRACT
Introduction. Superior vena cava (SVC) syndrome results from the obstruction of blood flow through the SVC, having distinct pathophysiological underlying mechanisms. Cancer is associated with an increased risk of thromboembolism that varies according to patient-, tumor-, and treatment-related factors. An individualized clinical approach is important to pursue the accurate diagnosis of the underlying pathology causing thromboembolism in cancer patients. Case Presentation. The authors present a case of a 58-year-old male with an infrequent presentation of an unknown colon carcinoma, who has never had any symptom until he was hospitalized with the diagnosis of superior vena cava syndrome and pulmonary thromboembolism. The patient had an advanced disease by the time of diagnosis and molecular alterations contributing to abnormal hemostasis. He presented venous and arterial thromboembolism and developed disseminated intravascular coagulopathy after surgery, anticoagulant and transfusion therapy, dying 40 days after the hospitalization. Conclusion. The authors discuss thromboembolic disease and tumor metastasis roles in a cancer patient with SVC syndrome. Thromboembolism in a malignancy context is a challenging clinical entity. A multifactorial perspective of the thrombotic disease is warranted to approach thromboembolism risk and stratify patients suitable to receive adequate anticoagulant prophylaxis and targeted therapies, aiming to improve clinical prognosis.

No MeSH data available.


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(a) Colon hepatic flexure tumor biopsy. Moderately differentiated adenocarcinoma of the colon hepatic flexure (hematoxylin and eosin staining, ×100). (b) Ascending colon tumor biopsy. Undifferentiated carcinoma of the ascending colon (hematoxylin and eosin staining, ×100).
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fig5: (a) Colon hepatic flexure tumor biopsy. Moderately differentiated adenocarcinoma of the colon hepatic flexure (hematoxylin and eosin staining, ×100). (b) Ascending colon tumor biopsy. Undifferentiated carcinoma of the ascending colon (hematoxylin and eosin staining, ×100).

Mentions: Immunohistological examination revealed 2 synchronous tumors: a 3 cm diameter moderately differentiated adenocarcinoma of the colon hepatic flexure and a 5 cm diameter undifferentiated carcinoma of the ascending colon, with a retroperitoneal malignant adenopathy mass of 7 cm diameter, and multiple venolymphatic emboli in the tumor stroma and mesenteric metastatic disease (T4N2M1) (Figures 5(a) and 5(b)).


Superior vena cava syndrome and colon carcinoma: a report of a multifactorial association.

Espírito Santo J, Coutinho I, Pimentel A, Garcia R, Marques Dos Santos R - Case Rep Oncol Med (2015)

(a) Colon hepatic flexure tumor biopsy. Moderately differentiated adenocarcinoma of the colon hepatic flexure (hematoxylin and eosin staining, ×100). (b) Ascending colon tumor biopsy. Undifferentiated carcinoma of the ascending colon (hematoxylin and eosin staining, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4355600&req=5

fig5: (a) Colon hepatic flexure tumor biopsy. Moderately differentiated adenocarcinoma of the colon hepatic flexure (hematoxylin and eosin staining, ×100). (b) Ascending colon tumor biopsy. Undifferentiated carcinoma of the ascending colon (hematoxylin and eosin staining, ×100).
Mentions: Immunohistological examination revealed 2 synchronous tumors: a 3 cm diameter moderately differentiated adenocarcinoma of the colon hepatic flexure and a 5 cm diameter undifferentiated carcinoma of the ascending colon, with a retroperitoneal malignant adenopathy mass of 7 cm diameter, and multiple venolymphatic emboli in the tumor stroma and mesenteric metastatic disease (T4N2M1) (Figures 5(a) and 5(b)).

Bottom Line: Cancer is associated with an increased risk of thromboembolism that varies according to patient-, tumor-, and treatment-related factors.The authors present a case of a 58-year-old male with an infrequent presentation of an unknown colon carcinoma, who has never had any symptom until he was hospitalized with the diagnosis of superior vena cava syndrome and pulmonary thromboembolism.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine Department A, University Hospital Center of Coimbra, 3000-075 Coimbra, Portugal.

ABSTRACT
Introduction. Superior vena cava (SVC) syndrome results from the obstruction of blood flow through the SVC, having distinct pathophysiological underlying mechanisms. Cancer is associated with an increased risk of thromboembolism that varies according to patient-, tumor-, and treatment-related factors. An individualized clinical approach is important to pursue the accurate diagnosis of the underlying pathology causing thromboembolism in cancer patients. Case Presentation. The authors present a case of a 58-year-old male with an infrequent presentation of an unknown colon carcinoma, who has never had any symptom until he was hospitalized with the diagnosis of superior vena cava syndrome and pulmonary thromboembolism. The patient had an advanced disease by the time of diagnosis and molecular alterations contributing to abnormal hemostasis. He presented venous and arterial thromboembolism and developed disseminated intravascular coagulopathy after surgery, anticoagulant and transfusion therapy, dying 40 days after the hospitalization. Conclusion. The authors discuss thromboembolic disease and tumor metastasis roles in a cancer patient with SVC syndrome. Thromboembolism in a malignancy context is a challenging clinical entity. A multifactorial perspective of the thrombotic disease is warranted to approach thromboembolism risk and stratify patients suitable to receive adequate anticoagulant prophylaxis and targeted therapies, aiming to improve clinical prognosis.

No MeSH data available.


Related in: MedlinePlus