Limits...
Xuesaitong injection as one adjuvant treatment of acute cerebral infarction: a systematic review and meta-analysis.

Zhang X, Wu J, Zhang B - BMC Complement Altern Med (2015)

Bottom Line: However, compared to the conventional therapy with western medicines (WM), the effectiveness and safety of XST as an adjuvant treatment for ACI needs to be systematically reviewed.The meta-analysis indicated that compared to WM, the combined use of XST and WM was more effective in terms of the total clinical effective rate [RR = 1.21, 95% CI (1.16, 1.25), P < 0.00001], neurological deficit scores [MD = -3.31, 95% CI (-4.10, -2.52), P < 0.00001], and plasma viscosity [MD = -0.13, 95% CI (-0.15, -0.11), P < 0.00001].XST combined with WM appeared to be effective for ACI.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. fensexiaomao@sina.com.

ABSTRACT

Background: Xuesaitong Injection (XST) is one of the most commonly used medicines for treating acute cerebral infarction (ACI) in China. However, compared to the conventional therapy with western medicines (WM), the effectiveness and safety of XST as an adjuvant treatment for ACI needs to be systematically reviewed.

Methods: Randomized controlled trials (RCTs) comparing XST & WM with WM for treating ACI were included. Two reviewers independently extracted data. The Cochrane table of Risk of Bias was used to assess the quality of the included studies, and a meta-analysis was conducted using Review Manager 5.2.

Results: 23 RCTs, involving 2196 participants, were included in this study. Methodological quality was not well. The meta-analysis indicated that compared to WM, the combined use of XST and WM was more effective in terms of the total clinical effective rate [RR = 1.21, 95% CI (1.16, 1.25), P < 0.00001], neurological deficit scores [MD = -3.31, 95% CI (-4.10, -2.52), P < 0.00001], and plasma viscosity [MD = -0.13, 95% CI (-0.15, -0.11), P < 0.00001]. The included studies reported 37 adverse events, 17 of which belonged to experimental groups.

Conclusion: XST combined with WM appeared to be effective for ACI. However, the evidence of XST for treating ACI should be carefully interpreted due to the small sample size, limited number of trials, and unsatisfactory quality of research.

Show MeSH

Related in: MedlinePlus

Meta-analysis of reducing the content of plasma viscosity of XST for treating ACI. XST: Xuesaitong Injection; ACI: acute cerebral infarction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4355548&req=5

Fig6: Meta-analysis of reducing the content of plasma viscosity of XST for treating ACI. XST: Xuesaitong Injection; ACI: acute cerebral infarction.

Mentions: There were five trials mentioned the content of plasma viscosity [15,17,23,28,31]. The result showed that XST was more effective in reducing the content of plasma viscosity. The statistical difference between two groups was significant [5 RCTs, I2 = 77%, random effect model, MD = −0.14, 95% CI (−0.21, −0.08), P < 0.00001]. (Shown in Figure 6).Figure 6


Xuesaitong injection as one adjuvant treatment of acute cerebral infarction: a systematic review and meta-analysis.

Zhang X, Wu J, Zhang B - BMC Complement Altern Med (2015)

Meta-analysis of reducing the content of plasma viscosity of XST for treating ACI. XST: Xuesaitong Injection; ACI: acute cerebral infarction.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4355548&req=5

Fig6: Meta-analysis of reducing the content of plasma viscosity of XST for treating ACI. XST: Xuesaitong Injection; ACI: acute cerebral infarction.
Mentions: There were five trials mentioned the content of plasma viscosity [15,17,23,28,31]. The result showed that XST was more effective in reducing the content of plasma viscosity. The statistical difference between two groups was significant [5 RCTs, I2 = 77%, random effect model, MD = −0.14, 95% CI (−0.21, −0.08), P < 0.00001]. (Shown in Figure 6).Figure 6

Bottom Line: However, compared to the conventional therapy with western medicines (WM), the effectiveness and safety of XST as an adjuvant treatment for ACI needs to be systematically reviewed.The meta-analysis indicated that compared to WM, the combined use of XST and WM was more effective in terms of the total clinical effective rate [RR = 1.21, 95% CI (1.16, 1.25), P < 0.00001], neurological deficit scores [MD = -3.31, 95% CI (-4.10, -2.52), P < 0.00001], and plasma viscosity [MD = -0.13, 95% CI (-0.15, -0.11), P < 0.00001].XST combined with WM appeared to be effective for ACI.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. fensexiaomao@sina.com.

ABSTRACT

Background: Xuesaitong Injection (XST) is one of the most commonly used medicines for treating acute cerebral infarction (ACI) in China. However, compared to the conventional therapy with western medicines (WM), the effectiveness and safety of XST as an adjuvant treatment for ACI needs to be systematically reviewed.

Methods: Randomized controlled trials (RCTs) comparing XST & WM with WM for treating ACI were included. Two reviewers independently extracted data. The Cochrane table of Risk of Bias was used to assess the quality of the included studies, and a meta-analysis was conducted using Review Manager 5.2.

Results: 23 RCTs, involving 2196 participants, were included in this study. Methodological quality was not well. The meta-analysis indicated that compared to WM, the combined use of XST and WM was more effective in terms of the total clinical effective rate [RR = 1.21, 95% CI (1.16, 1.25), P < 0.00001], neurological deficit scores [MD = -3.31, 95% CI (-4.10, -2.52), P < 0.00001], and plasma viscosity [MD = -0.13, 95% CI (-0.15, -0.11), P < 0.00001]. The included studies reported 37 adverse events, 17 of which belonged to experimental groups.

Conclusion: XST combined with WM appeared to be effective for ACI. However, the evidence of XST for treating ACI should be carefully interpreted due to the small sample size, limited number of trials, and unsatisfactory quality of research.

Show MeSH
Related in: MedlinePlus