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Chinese herbal medicine for myelosuppression induced by chemotherapy or radiotherapy: a systematic review of randomized controlled trials.

Jia Y, Du H, Yao M, Cui X, Shi Q, Wang Y, Yang Y - Evid Based Complement Alternat Med (2015)

Bottom Line: Objectives.Conclusions.There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

View Article: PubMed Central - PubMed

Affiliation: Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China ; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

ABSTRACT
Background. Myelosuppression is one of the major side effects of chemo- and radiotherapy in cancer patients and there are no effective interventions to prevent it currently. Chinese herbal medicine (CHM) may be helpful due to its multidrug targets. Objectives. This study was designed to evaluate effectiveness of CHM on preventing patients from experiencing myelosuppression by chemo- or radiotherapy. Search Methods. Randomized controlled trials (RCTs) were retrieved from seven different databases from the date of database creation to April 2014. We assessed all included studies using Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 and performed statistical analysis using RevMan 5.2.1. Results. Eight RCTs were included (818 patients). Pooled data showed that increase of white blood cells (WBCs) is higher with CHM plus chemotherapy/radiotherapy than with chemotherapy/radiotherapy only. Both CHM compared to placebo and CHM combined with chemotherapy/radiotherapy compared to chemotherapy/radiotherapy lacked significant differences in the peripheral platelets, red blood cells (RBCs), and hemoglobin changes. Conclusions. Our results demonstrated that CHM significantly protected peripheral blood WBCs from a decrease caused by chemotherapy or radiotherapy. There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

No MeSH data available.


Related in: MedlinePlus

Risk of bias graph: review authors' judgments about each risk of bias item presented as percentages across all included studies.
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fig2: Risk of bias graph: review authors' judgments about each risk of bias item presented as percentages across all included studies.

Mentions: The reports of all trials mentioned randomization, but only five described the method of randomization [35–39]. In addition, the reports of three trials mentioned double-blinding [32, 33, 38]. We assessed all included studies according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0. Figure 2 shows the results of the author's judgment about each methodological quality item for each included study. One of the studies was defined as medium quality and the others were of low quality.


Chinese herbal medicine for myelosuppression induced by chemotherapy or radiotherapy: a systematic review of randomized controlled trials.

Jia Y, Du H, Yao M, Cui X, Shi Q, Wang Y, Yang Y - Evid Based Complement Alternat Med (2015)

Risk of bias graph: review authors' judgments about each risk of bias item presented as percentages across all included studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352943&req=5

fig2: Risk of bias graph: review authors' judgments about each risk of bias item presented as percentages across all included studies.
Mentions: The reports of all trials mentioned randomization, but only five described the method of randomization [35–39]. In addition, the reports of three trials mentioned double-blinding [32, 33, 38]. We assessed all included studies according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0. Figure 2 shows the results of the author's judgment about each methodological quality item for each included study. One of the studies was defined as medium quality and the others were of low quality.

Bottom Line: Objectives.Conclusions.There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

View Article: PubMed Central - PubMed

Affiliation: Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China ; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

ABSTRACT
Background. Myelosuppression is one of the major side effects of chemo- and radiotherapy in cancer patients and there are no effective interventions to prevent it currently. Chinese herbal medicine (CHM) may be helpful due to its multidrug targets. Objectives. This study was designed to evaluate effectiveness of CHM on preventing patients from experiencing myelosuppression by chemo- or radiotherapy. Search Methods. Randomized controlled trials (RCTs) were retrieved from seven different databases from the date of database creation to April 2014. We assessed all included studies using Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 and performed statistical analysis using RevMan 5.2.1. Results. Eight RCTs were included (818 patients). Pooled data showed that increase of white blood cells (WBCs) is higher with CHM plus chemotherapy/radiotherapy than with chemotherapy/radiotherapy only. Both CHM compared to placebo and CHM combined with chemotherapy/radiotherapy compared to chemotherapy/radiotherapy lacked significant differences in the peripheral platelets, red blood cells (RBCs), and hemoglobin changes. Conclusions. Our results demonstrated that CHM significantly protected peripheral blood WBCs from a decrease caused by chemotherapy or radiotherapy. There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

No MeSH data available.


Related in: MedlinePlus