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Chinese herbal medicine for myelosuppression induced by chemotherapy or radiotherapy: a systematic review of randomized controlled trials.

Jia Y, Du H, Yao M, Cui X, Shi Q, Wang Y, Yang Y - Evid Based Complement Alternat Med (2015)

Bottom Line: Objectives.Conclusions.There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

View Article: PubMed Central - PubMed

Affiliation: Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China ; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

ABSTRACT
Background. Myelosuppression is one of the major side effects of chemo- and radiotherapy in cancer patients and there are no effective interventions to prevent it currently. Chinese herbal medicine (CHM) may be helpful due to its multidrug targets. Objectives. This study was designed to evaluate effectiveness of CHM on preventing patients from experiencing myelosuppression by chemo- or radiotherapy. Search Methods. Randomized controlled trials (RCTs) were retrieved from seven different databases from the date of database creation to April 2014. We assessed all included studies using Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 and performed statistical analysis using RevMan 5.2.1. Results. Eight RCTs were included (818 patients). Pooled data showed that increase of white blood cells (WBCs) is higher with CHM plus chemotherapy/radiotherapy than with chemotherapy/radiotherapy only. Both CHM compared to placebo and CHM combined with chemotherapy/radiotherapy compared to chemotherapy/radiotherapy lacked significant differences in the peripheral platelets, red blood cells (RBCs), and hemoglobin changes. Conclusions. Our results demonstrated that CHM significantly protected peripheral blood WBCs from a decrease caused by chemotherapy or radiotherapy. There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

No MeSH data available.


Related in: MedlinePlus

Flow of the included studies.
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Related In: Results  -  Collection


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fig1: Flow of the included studies.

Mentions: In total, 646 articles were retrieved following the search strategy described above (259 in English and 387 in Chinese). Potential studies, including 14 in English and 303 in Chinese, were identified by title and abstract screening to exclude trials that were duplicates [13, 14], reviews [15–17], animal studies [18–20], and case or experience reports [21, 22]. By reading the full text we excluded those studies with incorrect randomization or lack of randomization [23–25]; those studies that lacked original data of outcomes [10, 26–28]; and RCTs using acupuncture, massage, ear acupoint, medicine for exterior treatment [29–31]. Eight trials met the inclusion criteria (see the details in Figure 1) and were included in the final review. Two of the trials were published in English, and six of them were published in Chinese. Included studies were published from 2001 to 2013.


Chinese herbal medicine for myelosuppression induced by chemotherapy or radiotherapy: a systematic review of randomized controlled trials.

Jia Y, Du H, Yao M, Cui X, Shi Q, Wang Y, Yang Y - Evid Based Complement Alternat Med (2015)

Flow of the included studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352943&req=5

fig1: Flow of the included studies.
Mentions: In total, 646 articles were retrieved following the search strategy described above (259 in English and 387 in Chinese). Potential studies, including 14 in English and 303 in Chinese, were identified by title and abstract screening to exclude trials that were duplicates [13, 14], reviews [15–17], animal studies [18–20], and case or experience reports [21, 22]. By reading the full text we excluded those studies with incorrect randomization or lack of randomization [23–25]; those studies that lacked original data of outcomes [10, 26–28]; and RCTs using acupuncture, massage, ear acupoint, medicine for exterior treatment [29–31]. Eight trials met the inclusion criteria (see the details in Figure 1) and were included in the final review. Two of the trials were published in English, and six of them were published in Chinese. Included studies were published from 2001 to 2013.

Bottom Line: Objectives.Conclusions.There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

View Article: PubMed Central - PubMed

Affiliation: Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China ; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

ABSTRACT
Background. Myelosuppression is one of the major side effects of chemo- and radiotherapy in cancer patients and there are no effective interventions to prevent it currently. Chinese herbal medicine (CHM) may be helpful due to its multidrug targets. Objectives. This study was designed to evaluate effectiveness of CHM on preventing patients from experiencing myelosuppression by chemo- or radiotherapy. Search Methods. Randomized controlled trials (RCTs) were retrieved from seven different databases from the date of database creation to April 2014. We assessed all included studies using Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 and performed statistical analysis using RevMan 5.2.1. Results. Eight RCTs were included (818 patients). Pooled data showed that increase of white blood cells (WBCs) is higher with CHM plus chemotherapy/radiotherapy than with chemotherapy/radiotherapy only. Both CHM compared to placebo and CHM combined with chemotherapy/radiotherapy compared to chemotherapy/radiotherapy lacked significant differences in the peripheral platelets, red blood cells (RBCs), and hemoglobin changes. Conclusions. Our results demonstrated that CHM significantly protected peripheral blood WBCs from a decrease caused by chemotherapy or radiotherapy. There were no significant protective effects on peripheral RBCs, hemoglobin, or platelets, which may be related to low quality and small sample of included studies.

No MeSH data available.


Related in: MedlinePlus