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The effect of melatonin supplementation on the quality of sleep and weight status in postmenopausal women.

Walecka-Kapica E, Klupińska G, Chojnacki J, Tomaszewska-Warda K, Błońska A, Chojnacki C - Prz Menopauzalny (2014)

Bottom Line: In both groups a negative correlation was found between urinary 6-HMS excretion and the degree of sleep disorders.After 24 weeks, a statistically significant improvement of quality of sleep was obtained.Melatonin supplementation contributed to body weight reduction.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostic, Medical University of Lodz, Poland.

ABSTRACT

Aim of the study: We evaluated the effect of melatonin supplementation on the nutritional status of postmenopausal women.

Material and methods: The study included 56 women (51-65 years) and 25 healthy women (27-36 years). The emotional state was assessed using Hamilton Depression Rating Scale (HAM-D), the quality of sleep using Insomnia Severity Index (ISI). Body mass index (BMI) and waist-hip ratio (WHR) were also calculated. The patients were divided into 3 groups: group I (control) - 25 women with normal body weight, group II - 26 postmenopausal women with normal body weight, group III - 30 postmenopausal women with high body weight. In women from group II and III, routine laboratory tests, levels of thyroid-stimulating hormone (TSH), 17β-estradiol, prolactin, follicle-stimulating hormone (FSH) and the concentration of 6-hydroxymelatonin sulphate (6-HMS) in day/night urine fractions were determined. On the day of the examination, women remained on a liquid diet (1800 kcal). Next, a balanced diet of 1500 kcal and 5 mg of melatonin administration were recommended. The follow-up examinations were performed after 4, 8, 12, 16, 20 and 24 weeks.

Results: The patients from groups II and III showed similar mild levels of anxiety and depression and a significant degree of sleep disorders. In group III, lower urinary 6-HMS excretion was observed at night. In both groups a negative correlation was found between urinary 6-HMS excretion and the degree of sleep disorders. After 24 weeks, a statistically significant improvement of quality of sleep was obtained. A negative correlation was detected between urinary 6-HMS excretion and BMI.

Conclusion: Melatonin supplementation contributed to body weight reduction.

No MeSH data available.


Related in: MedlinePlus

Waist/hip ratio (WHR) before and after melatonin therapy in the groups of postmenopausal women of normal body weight (A) and with obesity (B)
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Figure 0003: Waist/hip ratio (WHR) before and after melatonin therapy in the groups of postmenopausal women of normal body weight (A) and with obesity (B)

Mentions: The initial examination revealed a negative correlation between urinary 6-HMS excretion and body mass index (Table II). Melatonin supplementation contributed to the reduction of body weight in obese women and after 16 weeks, BMI decreased from 29.62 ± 3.69 to 27.88 ± 3.14 (p < 0.001). The tendency to the reduction in body weight was also observed in group II of women without obesity (Fig. 2). Waist-hip ratio values exhibited similar tendency but the results did not differ statistically (Fig. 3).


The effect of melatonin supplementation on the quality of sleep and weight status in postmenopausal women.

Walecka-Kapica E, Klupińska G, Chojnacki J, Tomaszewska-Warda K, Błońska A, Chojnacki C - Prz Menopauzalny (2014)

Waist/hip ratio (WHR) before and after melatonin therapy in the groups of postmenopausal women of normal body weight (A) and with obesity (B)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352910&req=5

Figure 0003: Waist/hip ratio (WHR) before and after melatonin therapy in the groups of postmenopausal women of normal body weight (A) and with obesity (B)
Mentions: The initial examination revealed a negative correlation between urinary 6-HMS excretion and body mass index (Table II). Melatonin supplementation contributed to the reduction of body weight in obese women and after 16 weeks, BMI decreased from 29.62 ± 3.69 to 27.88 ± 3.14 (p < 0.001). The tendency to the reduction in body weight was also observed in group II of women without obesity (Fig. 2). Waist-hip ratio values exhibited similar tendency but the results did not differ statistically (Fig. 3).

Bottom Line: In both groups a negative correlation was found between urinary 6-HMS excretion and the degree of sleep disorders.After 24 weeks, a statistically significant improvement of quality of sleep was obtained.Melatonin supplementation contributed to body weight reduction.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Nutrition and Gastroenterological Diagnostic, Medical University of Lodz, Poland.

ABSTRACT

Aim of the study: We evaluated the effect of melatonin supplementation on the nutritional status of postmenopausal women.

Material and methods: The study included 56 women (51-65 years) and 25 healthy women (27-36 years). The emotional state was assessed using Hamilton Depression Rating Scale (HAM-D), the quality of sleep using Insomnia Severity Index (ISI). Body mass index (BMI) and waist-hip ratio (WHR) were also calculated. The patients were divided into 3 groups: group I (control) - 25 women with normal body weight, group II - 26 postmenopausal women with normal body weight, group III - 30 postmenopausal women with high body weight. In women from group II and III, routine laboratory tests, levels of thyroid-stimulating hormone (TSH), 17β-estradiol, prolactin, follicle-stimulating hormone (FSH) and the concentration of 6-hydroxymelatonin sulphate (6-HMS) in day/night urine fractions were determined. On the day of the examination, women remained on a liquid diet (1800 kcal). Next, a balanced diet of 1500 kcal and 5 mg of melatonin administration were recommended. The follow-up examinations were performed after 4, 8, 12, 16, 20 and 24 weeks.

Results: The patients from groups II and III showed similar mild levels of anxiety and depression and a significant degree of sleep disorders. In group III, lower urinary 6-HMS excretion was observed at night. In both groups a negative correlation was found between urinary 6-HMS excretion and the degree of sleep disorders. After 24 weeks, a statistically significant improvement of quality of sleep was obtained. A negative correlation was detected between urinary 6-HMS excretion and BMI.

Conclusion: Melatonin supplementation contributed to body weight reduction.

No MeSH data available.


Related in: MedlinePlus