Limits...
A pilot study: the efficacy of virgin coconut oil as ocular rewetting agent on rabbit eyes.

Mutalib HA, Kaur S, Ghazali AR, Chinn Hooi N, Safie NH - Evid Based Complement Alternat Med (2015)

Bottom Line: However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P > 0.05).VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline.These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

View Article: PubMed Central - PubMed

Affiliation: Programme of Optometry & Vision Sciences, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

ABSTRACT
Purpose. An open-label pilot study of virgin coconut oil (VCO) was conducted to determine the safety of the agent as ocular rewetting eye drops on rabbits. Methods. Efficacy of the VCO was assessed by measuring NIBUT, anterior eye assessment, corneal staining, pH, and Schirmer value before instillation and at 30 min, 60 min, and two weeks after instillation. Friedman test was used to analyse any changes in all the measurable variables over the period of time. Results. Only conjunctival redness with instillation of saline agent showed significant difference over the period of time (P < 0.05). However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P > 0.05). There were no changes in the NIBUT, limbal redness, palpebral conjunctiva redness, corneal staining, pH, and Schirmer value over the period of time for each agent (P > 0.05). Conclusion. VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline. These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

No MeSH data available.


Related in: MedlinePlus

Changes of NIBUT value for tested eye.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4352907&req=5

fig1: Changes of NIBUT value for tested eye.

Mentions: After instillation of a drop of VCO, Tears Naturale II, and saline, there was no significant increase in tear film stability at 30 min, 60 min, and 2 weeks in comparison with baseline distribution (P > 0.05, Figure 1). Furthermore, after treatment of VCO, Tears Naturale II, and saline, there was also no significance difference found in the corneal staining, limbal hyperemia, and palpebral hyperemia at 30 min, 60 min, and 2 weeks in comparison with baseline distribution (P > 0.05). Even though VCO and Tears Naturale II did not show significance difference in the conjunctival hyperemia (P > 0.05) over the period of study, saline treated eyes showed a significant increase (P < 0.05) in the conjunctival hyperemia over the period of study. However, further statistical analysis showed the saline studies eye had no significant difference (P > 0.05) over the baseline readings. In treatment with VCO, it was noticed that it was slightly irritant to rabbit eyes, causing transient inflammation on the eyelid. The rabbits were annoyed and some itching of eyelids was observed for 1 minute after application of VCO.


A pilot study: the efficacy of virgin coconut oil as ocular rewetting agent on rabbit eyes.

Mutalib HA, Kaur S, Ghazali AR, Chinn Hooi N, Safie NH - Evid Based Complement Alternat Med (2015)

Changes of NIBUT value for tested eye.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352907&req=5

fig1: Changes of NIBUT value for tested eye.
Mentions: After instillation of a drop of VCO, Tears Naturale II, and saline, there was no significant increase in tear film stability at 30 min, 60 min, and 2 weeks in comparison with baseline distribution (P > 0.05, Figure 1). Furthermore, after treatment of VCO, Tears Naturale II, and saline, there was also no significance difference found in the corneal staining, limbal hyperemia, and palpebral hyperemia at 30 min, 60 min, and 2 weeks in comparison with baseline distribution (P > 0.05). Even though VCO and Tears Naturale II did not show significance difference in the conjunctival hyperemia (P > 0.05) over the period of study, saline treated eyes showed a significant increase (P < 0.05) in the conjunctival hyperemia over the period of study. However, further statistical analysis showed the saline studies eye had no significant difference (P > 0.05) over the baseline readings. In treatment with VCO, it was noticed that it was slightly irritant to rabbit eyes, causing transient inflammation on the eyelid. The rabbits were annoyed and some itching of eyelids was observed for 1 minute after application of VCO.

Bottom Line: However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P > 0.05).VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline.These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

View Article: PubMed Central - PubMed

Affiliation: Programme of Optometry & Vision Sciences, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

ABSTRACT
Purpose. An open-label pilot study of virgin coconut oil (VCO) was conducted to determine the safety of the agent as ocular rewetting eye drops on rabbits. Methods. Efficacy of the VCO was assessed by measuring NIBUT, anterior eye assessment, corneal staining, pH, and Schirmer value before instillation and at 30 min, 60 min, and two weeks after instillation. Friedman test was used to analyse any changes in all the measurable variables over the period of time. Results. Only conjunctival redness with instillation of saline agent showed significant difference over the period of time (P < 0.05). However, further statistical analysis had shown no significant difference at 30 min, 60 min, and two weeks compared to initial measurement (P > 0.05). There were no changes in the NIBUT, limbal redness, palpebral conjunctiva redness, corneal staining, pH, and Schirmer value over the period of time for each agent (P > 0.05). Conclusion. VCO acts as safe rewetting eye drops as it has shown no significant difference in the measurable parameter compared to commercial brand eye drops and saline. These study data suggest that VCO is safe to be used as ocular rewetting agent on human being.

No MeSH data available.


Related in: MedlinePlus