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Increased Mercury Levels in Patients with Celiac Disease following a Gluten-Free Regimen.

Elli L, Rossi V, Conte D, Ronchi A, Tomba C, Passoni M, Bardella MT, Roncoroni L, Guzzi G - Gastroenterol Res Pract (2015)

Bottom Line: Although mercury is involved in several immunological diseases, nothing is known about its implication in celiac disease.No demographic or clinical data were significantly associated with mercury levels in biologic samples.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Center for the Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy.

ABSTRACT
Background and Aim. Although mercury is involved in several immunological diseases, nothing is known about its implication in celiac disease. Our aim was to evaluate blood and urinary levels of mercury in celiac patients. Methods. We prospectively enrolled 30 celiac patients (20 treated with normal duodenal mucosa and 10 untreated with duodenal atrophy) and 20 healthy controls from the same geographic area. Blood and urinary mercury concentrations were measured by means of flow injection inductively coupled plasma mass spectrometry. Enrolled patients underwent dental chart for amalgam fillings and completed a food-frequency questionnaire to evaluate diet and fish intake. Results. Mercury blood/urinary levels were 2.4 ± 2.3/1.0 ± 1.4, 10.2 ± 6.7/2.2 ± 3.0 and 3.7 ± 2.7/1.3 ± 1.2 in untreated CD, treated CD, and healthy controls, respectively. Resulting mercury levels were significantly higher in celiac patients following a gluten-free diet. No differences were found regarding fish intake and number of amalgam fillings. No demographic or clinical data were significantly associated with mercury levels in biologic samples. Conclusion. Data demonstrate a fourfold increase of mercury blood levels in celiac patients following a gluten-free diet. Further studies are needed to clarify its role in celiac mechanism.

No MeSH data available.


Related in: MedlinePlus

Mercury (Hg) blood levels of untreated and treated celiac (CD) patients and healthy controls. Mean, 95% confidence intervals, and statistical significance are reported in the plot.
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fig1: Mercury (Hg) blood levels of untreated and treated celiac (CD) patients and healthy controls. Mean, 95% confidence intervals, and statistical significance are reported in the plot.

Mentions: Details of blood and urinary Hg levels of the analysed groups are reported in Table 2. Mercury blood levels resulting significantly increased in treated CD patients compared to untreated CD, as detailed in Figure 1.


Increased Mercury Levels in Patients with Celiac Disease following a Gluten-Free Regimen.

Elli L, Rossi V, Conte D, Ronchi A, Tomba C, Passoni M, Bardella MT, Roncoroni L, Guzzi G - Gastroenterol Res Pract (2015)

Mercury (Hg) blood levels of untreated and treated celiac (CD) patients and healthy controls. Mean, 95% confidence intervals, and statistical significance are reported in the plot.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352902&req=5

fig1: Mercury (Hg) blood levels of untreated and treated celiac (CD) patients and healthy controls. Mean, 95% confidence intervals, and statistical significance are reported in the plot.
Mentions: Details of blood and urinary Hg levels of the analysed groups are reported in Table 2. Mercury blood levels resulting significantly increased in treated CD patients compared to untreated CD, as detailed in Figure 1.

Bottom Line: Although mercury is involved in several immunological diseases, nothing is known about its implication in celiac disease.No demographic or clinical data were significantly associated with mercury levels in biologic samples.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Center for the Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy.

ABSTRACT
Background and Aim. Although mercury is involved in several immunological diseases, nothing is known about its implication in celiac disease. Our aim was to evaluate blood and urinary levels of mercury in celiac patients. Methods. We prospectively enrolled 30 celiac patients (20 treated with normal duodenal mucosa and 10 untreated with duodenal atrophy) and 20 healthy controls from the same geographic area. Blood and urinary mercury concentrations were measured by means of flow injection inductively coupled plasma mass spectrometry. Enrolled patients underwent dental chart for amalgam fillings and completed a food-frequency questionnaire to evaluate diet and fish intake. Results. Mercury blood/urinary levels were 2.4 ± 2.3/1.0 ± 1.4, 10.2 ± 6.7/2.2 ± 3.0 and 3.7 ± 2.7/1.3 ± 1.2 in untreated CD, treated CD, and healthy controls, respectively. Resulting mercury levels were significantly higher in celiac patients following a gluten-free diet. No differences were found regarding fish intake and number of amalgam fillings. No demographic or clinical data were significantly associated with mercury levels in biologic samples. Conclusion. Data demonstrate a fourfold increase of mercury blood levels in celiac patients following a gluten-free diet. Further studies are needed to clarify its role in celiac mechanism.

No MeSH data available.


Related in: MedlinePlus