Limits...
Cytomegalovirus colitis with common variable immunodeficiency and Crohn's disease.

Ünal B, Başsorgun Cİ, Çil Gönülcü S, Uçar A, Çelik F, Elpek GÖ - Case Rep Med (2015)

Bottom Line: Despite immunoglobulin and antiviral therapies, general condition of patient deteriorated and he died in the postoperative seventh day.Laboratory analysis was seronegative.CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Medicine, Akdeniz University, Turkey.

ABSTRACT
Here we present an eleven-year-old male patient who had been diagnosed with common variable immunodeficiency (CVID) three years ago due to recurrent sinopulmonary infections. Two years later he had been diagnosed with Crohn's disease (CD) due to diarrhea episodes which were unresponsive to the treatment. Depending on the active gastrointestinal bleeding and perforation he underwent total colectomy. Despite immunoglobulin and antiviral therapies, general condition of patient deteriorated and he died in the postoperative seventh day. Laboratory analysis was seronegative. CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes.

No MeSH data available.


Related in: MedlinePlus

Macroscopic appearance of colectomy material. Mucosa is hemorrhagic and hyperemic; multiple foci of ulcer and perforation areas are seen.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4352901&req=5

fig1: Macroscopic appearance of colectomy material. Mucosa is hemorrhagic and hyperemic; multiple foci of ulcer and perforation areas are seen.

Mentions: Here we present an eleven-year-old male patient who had been diagnosed with CVID three years ago due to recurrent sinopulmonary infections and two years later with CD due to diarrhea episodes which were unresponsive to treatment. He was admitted to our hospital with the complaint of blood in the stool. Laboratory analysis was performed and he was seronegative. He underwent surgery and total colectomy was performed due to active gastrointestinal bleeding and perforation. In macroscopic examination (Figure 1), a perforation area was seen in colectomy material. Mucosa was hemorrhagic and hyperemic, it was flattened in some areas, and multiple foci of ulcer were seen. Microscopic examination revealed intranuclear and cytoplasmic inclusions in fibroblasts, endothelial cells, and mononuclear cells in the base of mucosal ulcer area (Figures 2(a) and 2(b)). In adjacent mucosa, widespread apoptosis within crypts, neutrophilic (PMNL) and eosinophilic infiltration, cryptitis, and a small number of crypt abscesses were seen (Figure 2(c)). Immunohistochemical analysis revealed the CMV positivity in inclusion containing cells (Figures 2(d) and 2(e)). Despite immunoglobulin and antiviral therapies, general condition deteriorated and he died in the postoperative seventh day. CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes (Figures 3 and 4).


Cytomegalovirus colitis with common variable immunodeficiency and Crohn's disease.

Ünal B, Başsorgun Cİ, Çil Gönülcü S, Uçar A, Çelik F, Elpek GÖ - Case Rep Med (2015)

Macroscopic appearance of colectomy material. Mucosa is hemorrhagic and hyperemic; multiple foci of ulcer and perforation areas are seen.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352901&req=5

fig1: Macroscopic appearance of colectomy material. Mucosa is hemorrhagic and hyperemic; multiple foci of ulcer and perforation areas are seen.
Mentions: Here we present an eleven-year-old male patient who had been diagnosed with CVID three years ago due to recurrent sinopulmonary infections and two years later with CD due to diarrhea episodes which were unresponsive to treatment. He was admitted to our hospital with the complaint of blood in the stool. Laboratory analysis was performed and he was seronegative. He underwent surgery and total colectomy was performed due to active gastrointestinal bleeding and perforation. In macroscopic examination (Figure 1), a perforation area was seen in colectomy material. Mucosa was hemorrhagic and hyperemic, it was flattened in some areas, and multiple foci of ulcer were seen. Microscopic examination revealed intranuclear and cytoplasmic inclusions in fibroblasts, endothelial cells, and mononuclear cells in the base of mucosal ulcer area (Figures 2(a) and 2(b)). In adjacent mucosa, widespread apoptosis within crypts, neutrophilic (PMNL) and eosinophilic infiltration, cryptitis, and a small number of crypt abscesses were seen (Figure 2(c)). Immunohistochemical analysis revealed the CMV positivity in inclusion containing cells (Figures 2(d) and 2(e)). Despite immunoglobulin and antiviral therapies, general condition deteriorated and he died in the postoperative seventh day. CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes (Figures 3 and 4).

Bottom Line: Despite immunoglobulin and antiviral therapies, general condition of patient deteriorated and he died in the postoperative seventh day.Laboratory analysis was seronegative.CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, School of Medicine, Akdeniz University, Turkey.

ABSTRACT
Here we present an eleven-year-old male patient who had been diagnosed with common variable immunodeficiency (CVID) three years ago due to recurrent sinopulmonary infections. Two years later he had been diagnosed with Crohn's disease (CD) due to diarrhea episodes which were unresponsive to the treatment. Depending on the active gastrointestinal bleeding and perforation he underwent total colectomy. Despite immunoglobulin and antiviral therapies, general condition of patient deteriorated and he died in the postoperative seventh day. Laboratory analysis was seronegative. CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes.

No MeSH data available.


Related in: MedlinePlus