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The effects of puberty on white matter development in boys.

Menzies L, Goddings AL, Whitaker KJ, Blakemore SJ, Viner RM - Dev Cogn Neurosci (2014)

Bottom Line: Most studies have focused on age-related effects, whilst puberty-related changes are not well understood.In addition, testosterone was correlated with MD in these pubertally significant regions.In conclusion, pubertal status was significantly related to MD, but not FA, and this relationship cannot be explained by changes in chronological age alone.

View Article: PubMed Central - PubMed

Affiliation: University College London Institute of Cognitive Neuroscience, Alexandra House, 17 Queen Square, London WC1N 3AR, UK; General Adolescent and Paediatric Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: lacmenzies@gmail.com.

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The relationship between hormonal levels, pubertal status and mean diffusivity in white matter regions that showed a significant effect of pubertal status. Scatter plots of MD within the pubertally significant regions are shown for testosterone, DHEA and Oestradiol. Markers indicate individual data, black lines indicate linear regression lines, R and p values for Pearson's correlations are shown also. Significant correlation between MD and salivary hormone level was seen only for testosterone.
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fig0015: The relationship between hormonal levels, pubertal status and mean diffusivity in white matter regions that showed a significant effect of pubertal status. Scatter plots of MD within the pubertally significant regions are shown for testosterone, DHEA and Oestradiol. Markers indicate individual data, black lines indicate linear regression lines, R and p values for Pearson's correlations are shown also. Significant correlation between MD and salivary hormone level was seen only for testosterone.

Mentions: To assess whether the pubertal effects on white matter tracts were related to salivary hormone levels, we investigated whether there was any correlation between MD and hormone level. We found a significant correlation between salivary testosterone and MD (R = −0.30, n = 56, p = 0.023) with a decrease in MD as testosterone increased. There was no relationship with MD for either DHEA or oestradiol (Fig. 3). Addition of testosterone to the puberty only and interaction regression models of MD development did not improve the fit of either model.


The effects of puberty on white matter development in boys.

Menzies L, Goddings AL, Whitaker KJ, Blakemore SJ, Viner RM - Dev Cogn Neurosci (2014)

The relationship between hormonal levels, pubertal status and mean diffusivity in white matter regions that showed a significant effect of pubertal status. Scatter plots of MD within the pubertally significant regions are shown for testosterone, DHEA and Oestradiol. Markers indicate individual data, black lines indicate linear regression lines, R and p values for Pearson's correlations are shown also. Significant correlation between MD and salivary hormone level was seen only for testosterone.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352899&req=5

fig0015: The relationship between hormonal levels, pubertal status and mean diffusivity in white matter regions that showed a significant effect of pubertal status. Scatter plots of MD within the pubertally significant regions are shown for testosterone, DHEA and Oestradiol. Markers indicate individual data, black lines indicate linear regression lines, R and p values for Pearson's correlations are shown also. Significant correlation between MD and salivary hormone level was seen only for testosterone.
Mentions: To assess whether the pubertal effects on white matter tracts were related to salivary hormone levels, we investigated whether there was any correlation between MD and hormone level. We found a significant correlation between salivary testosterone and MD (R = −0.30, n = 56, p = 0.023) with a decrease in MD as testosterone increased. There was no relationship with MD for either DHEA or oestradiol (Fig. 3). Addition of testosterone to the puberty only and interaction regression models of MD development did not improve the fit of either model.

Bottom Line: Most studies have focused on age-related effects, whilst puberty-related changes are not well understood.In addition, testosterone was correlated with MD in these pubertally significant regions.In conclusion, pubertal status was significantly related to MD, but not FA, and this relationship cannot be explained by changes in chronological age alone.

View Article: PubMed Central - PubMed

Affiliation: University College London Institute of Cognitive Neuroscience, Alexandra House, 17 Queen Square, London WC1N 3AR, UK; General Adolescent and Paediatric Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: lacmenzies@gmail.com.

Show MeSH
Related in: MedlinePlus