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Genetic variability and phylogenetic analysis of Han population from Guanzhong region of China based on 21 non-CODIS STR loci.

Zhang YD, Tang XL, Meng HT, Wang HD, Jin R, Yang CH, Yan JW, Yang G, Liu WJ, Shen CM, Zhu BF - Sci Rep (2015)

Bottom Line: The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively.The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested.In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with corresponding allelic frequencies ranging from 0.0018 to 0.5564. No STR locus was observed to deviate from the Hardy-Weinberg equilibrium and linkage disequilibriums after applying Bonferroni correction. The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively. The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested. In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

Show MeSH
Phylogenetic tree for Guanzhong Han and 10 reference populations constructed by the software MEGA v5 based on DA distances (A) and by the software PHYLIP v3.6 based on allelic frequencies (B), respectively.
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f2: Phylogenetic tree for Guanzhong Han and 10 reference populations constructed by the software MEGA v5 based on DA distances (A) and by the software PHYLIP v3.6 based on allelic frequencies (B), respectively.

Mentions: The phylogenetic tree constructed by the software MEGA v5 based on DA distances was shown in Figure 2A. From the figure, three clusters were observed: the Guanzhong Han, Ningxia Han, Tibetan, Tujia and Bai groups shared the same clade; Yi, Russian, Salar and Mongolian groups were delineated in a branch; the remaining groups including Uigur and Kazak groups clustered together. In order to further confirm the phylogenetic relationship, the phylogenetic tree was also constructed using PHYLIP v3.6 based on the allelic frequencies of 21 STR loci and the result was shown in Figure 2B. The results obtained from two phylogenetic trees were extremely similar, and the only exception was Tibetan group. The exception may due to the different number of STR loci.


Genetic variability and phylogenetic analysis of Han population from Guanzhong region of China based on 21 non-CODIS STR loci.

Zhang YD, Tang XL, Meng HT, Wang HD, Jin R, Yang CH, Yan JW, Yang G, Liu WJ, Shen CM, Zhu BF - Sci Rep (2015)

Phylogenetic tree for Guanzhong Han and 10 reference populations constructed by the software MEGA v5 based on DA distances (A) and by the software PHYLIP v3.6 based on allelic frequencies (B), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352849&req=5

f2: Phylogenetic tree for Guanzhong Han and 10 reference populations constructed by the software MEGA v5 based on DA distances (A) and by the software PHYLIP v3.6 based on allelic frequencies (B), respectively.
Mentions: The phylogenetic tree constructed by the software MEGA v5 based on DA distances was shown in Figure 2A. From the figure, three clusters were observed: the Guanzhong Han, Ningxia Han, Tibetan, Tujia and Bai groups shared the same clade; Yi, Russian, Salar and Mongolian groups were delineated in a branch; the remaining groups including Uigur and Kazak groups clustered together. In order to further confirm the phylogenetic relationship, the phylogenetic tree was also constructed using PHYLIP v3.6 based on the allelic frequencies of 21 STR loci and the result was shown in Figure 2B. The results obtained from two phylogenetic trees were extremely similar, and the only exception was Tibetan group. The exception may due to the different number of STR loci.

Bottom Line: The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively.The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested.In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with corresponding allelic frequencies ranging from 0.0018 to 0.5564. No STR locus was observed to deviate from the Hardy-Weinberg equilibrium and linkage disequilibriums after applying Bonferroni correction. The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively. The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested. In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

Show MeSH