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Genetic variability and phylogenetic analysis of Han population from Guanzhong region of China based on 21 non-CODIS STR loci.

Zhang YD, Tang XL, Meng HT, Wang HD, Jin R, Yang CH, Yan JW, Yang G, Liu WJ, Shen CM, Zhu BF - Sci Rep (2015)

Bottom Line: The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively.The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested.In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with corresponding allelic frequencies ranging from 0.0018 to 0.5564. No STR locus was observed to deviate from the Hardy-Weinberg equilibrium and linkage disequilibriums after applying Bonferroni correction. The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively. The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested. In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

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The geographical locations of the Guanzhong Han and 10 reference groups in China.The map was created in matlab R2013b software (MathWorks Inc., USA).
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f1: The geographical locations of the Guanzhong Han and 10 reference groups in China.The map was created in matlab R2013b software (MathWorks Inc., USA).

Mentions: Genotyping results of the 21 STR loci from 10 Chinese groups were chosen for population comparison, including Mongolian (n = 86) from Inner Mongolia autonomous region6, Bai (n = 106) from Yunnan province7, Kazak (n = 114) from Xinjiang autonomous region8, Ningxia Han (Northern Han) (n = 202) from Ningxia autonomous region9, Russian (n = 114) from Inner Mongolia autonomous region10, Tibetan (n = 104) from Tibet autonomous region11, Tujia (n = 107) from Hubei province12, Uigur (n = 218) from Xinjiang autonomous region13, Yi (n = 110) from Yunnan province14, Salar (n = 120) from Qinghai province16. The geographical locations of the reference populations were shown in Figure 1.


Genetic variability and phylogenetic analysis of Han population from Guanzhong region of China based on 21 non-CODIS STR loci.

Zhang YD, Tang XL, Meng HT, Wang HD, Jin R, Yang CH, Yan JW, Yang G, Liu WJ, Shen CM, Zhu BF - Sci Rep (2015)

The geographical locations of the Guanzhong Han and 10 reference groups in China.The map was created in matlab R2013b software (MathWorks Inc., USA).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352849&req=5

f1: The geographical locations of the Guanzhong Han and 10 reference groups in China.The map was created in matlab R2013b software (MathWorks Inc., USA).
Mentions: Genotyping results of the 21 STR loci from 10 Chinese groups were chosen for population comparison, including Mongolian (n = 86) from Inner Mongolia autonomous region6, Bai (n = 106) from Yunnan province7, Kazak (n = 114) from Xinjiang autonomous region8, Ningxia Han (Northern Han) (n = 202) from Ningxia autonomous region9, Russian (n = 114) from Inner Mongolia autonomous region10, Tibetan (n = 104) from Tibet autonomous region11, Tujia (n = 107) from Hubei province12, Uigur (n = 218) from Xinjiang autonomous region13, Yi (n = 110) from Yunnan province14, Salar (n = 120) from Qinghai province16. The geographical locations of the reference populations were shown in Figure 1.

Bottom Line: The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively.The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested.In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with corresponding allelic frequencies ranging from 0.0018 to 0.5564. No STR locus was observed to deviate from the Hardy-Weinberg equilibrium and linkage disequilibriums after applying Bonferroni correction. The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively. The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested. In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

Show MeSH