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Serous tubal intraepithelial carcinoma: an incidental finding at the time of prophylactic bilateral salpingo-oophorectomy.

Vaughan MH, Modesitt SC, Mo Y, Trowbridge ER - Case Rep Obstet Gynecol (2015)

Bottom Line: Conclusion.Possible management options include observation with annual physical exam and CA-125, surgical staging, or empiric chemotherapy.However, due to the lack of consensus regarding management options, referral to a gynecologic oncologist is recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.

ABSTRACT
Background. Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion for high-grade pelvic serous carcinoma. The incidence of STIC is estimated to occur in 0.6% to 6% of women who are BRCA positive or have a strong family history of breast or ovarian cancer. Case. A 56-year-old woman underwent robotic-assisted sacrocolpopexy, rectocele repair, and concurrent bilateral salpingo-oophorectomy for recurrent stage 3 pelvic organ prolapse and reported family history of ovarian cancer. Histopathologic examination of her left fallopian tube revealed STIC. Conclusion. We report this rare occurrence of STIC in a patient undergoing surgery primarily for pelvic organ prolapse and having a family history of ovarian cancer. Possible management options include observation with annual physical exam and CA-125, surgical staging, or empiric chemotherapy. However, due to the lack of consensus regarding management options, referral to a gynecologic oncologist is recommended.

No MeSH data available.


Related in: MedlinePlus

(a) H&E stain of the distal fimbriated end of the left fallopian tube. At low magnification, the area of STIC demonstrates increased epithelial thickness and nuclear stratification compared to areas of normal tubal epithelium. (b) Area of STIC with nuclear stratification and moderate variability in size and shape. Also note the absence of ciliated cells within the lesional area. (c) At high magnification, nuclear atypia is clearly visible, including hyperchromatism, prominent nucleoli, loss of polarity, and increased mitotic figures. (d) Strong and diffuse nuclear TP53 staining of STIC.
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fig1: (a) H&E stain of the distal fimbriated end of the left fallopian tube. At low magnification, the area of STIC demonstrates increased epithelial thickness and nuclear stratification compared to areas of normal tubal epithelium. (b) Area of STIC with nuclear stratification and moderate variability in size and shape. Also note the absence of ciliated cells within the lesional area. (c) At high magnification, nuclear atypia is clearly visible, including hyperchromatism, prominent nucleoli, loss of polarity, and increased mitotic figures. (d) Strong and diffuse nuclear TP53 staining of STIC.

Mentions: She had an uneventful postoperative course and was discharged home on postoperative day number 2. Histopathologic examination of the specimen returned with serous tubal intraepithelial carcinoma of the fimbriated portion of the left fallopian tube. The left ovary along with the right fallopian tube and right ovary revealed no pathologic abnormality. Figure 1 depicts the histologic findings of STIC, including nuclear atypia, loss of polarity, increased mitoses, and positive p53 staining.


Serous tubal intraepithelial carcinoma: an incidental finding at the time of prophylactic bilateral salpingo-oophorectomy.

Vaughan MH, Modesitt SC, Mo Y, Trowbridge ER - Case Rep Obstet Gynecol (2015)

(a) H&E stain of the distal fimbriated end of the left fallopian tube. At low magnification, the area of STIC demonstrates increased epithelial thickness and nuclear stratification compared to areas of normal tubal epithelium. (b) Area of STIC with nuclear stratification and moderate variability in size and shape. Also note the absence of ciliated cells within the lesional area. (c) At high magnification, nuclear atypia is clearly visible, including hyperchromatism, prominent nucleoli, loss of polarity, and increased mitotic figures. (d) Strong and diffuse nuclear TP53 staining of STIC.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352759&req=5

fig1: (a) H&E stain of the distal fimbriated end of the left fallopian tube. At low magnification, the area of STIC demonstrates increased epithelial thickness and nuclear stratification compared to areas of normal tubal epithelium. (b) Area of STIC with nuclear stratification and moderate variability in size and shape. Also note the absence of ciliated cells within the lesional area. (c) At high magnification, nuclear atypia is clearly visible, including hyperchromatism, prominent nucleoli, loss of polarity, and increased mitotic figures. (d) Strong and diffuse nuclear TP53 staining of STIC.
Mentions: She had an uneventful postoperative course and was discharged home on postoperative day number 2. Histopathologic examination of the specimen returned with serous tubal intraepithelial carcinoma of the fimbriated portion of the left fallopian tube. The left ovary along with the right fallopian tube and right ovary revealed no pathologic abnormality. Figure 1 depicts the histologic findings of STIC, including nuclear atypia, loss of polarity, increased mitoses, and positive p53 staining.

Bottom Line: Conclusion.Possible management options include observation with annual physical exam and CA-125, surgical staging, or empiric chemotherapy.However, due to the lack of consensus regarding management options, referral to a gynecologic oncologist is recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.

ABSTRACT
Background. Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion for high-grade pelvic serous carcinoma. The incidence of STIC is estimated to occur in 0.6% to 6% of women who are BRCA positive or have a strong family history of breast or ovarian cancer. Case. A 56-year-old woman underwent robotic-assisted sacrocolpopexy, rectocele repair, and concurrent bilateral salpingo-oophorectomy for recurrent stage 3 pelvic organ prolapse and reported family history of ovarian cancer. Histopathologic examination of her left fallopian tube revealed STIC. Conclusion. We report this rare occurrence of STIC in a patient undergoing surgery primarily for pelvic organ prolapse and having a family history of ovarian cancer. Possible management options include observation with annual physical exam and CA-125, surgical staging, or empiric chemotherapy. However, due to the lack of consensus regarding management options, referral to a gynecologic oncologist is recommended.

No MeSH data available.


Related in: MedlinePlus