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Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.

Marín L, Miguélez EM, Villar CJ, Lombó F - Biomed Res Int (2015)

Bottom Line: Most of them occur as glycosylated derivatives in plants and foods.During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities.This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.

View Article: PubMed Central - PubMed

Affiliation: Research Unit "Biotechnology and Experimental Therapy Based in Nutraceuticals-BITTEN", Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.

ABSTRACT
Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.

No MeSH data available.


Related in: MedlinePlus

Colonic degradation of malvidin-3-glucoside, as an example of anthocyanin.
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Related In: Results  -  Collection


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fig7: Colonic degradation of malvidin-3-glucoside, as an example of anthocyanin.

Mentions: Since only a small part of ingested anthocyanins is absorbed at small intestine, large amounts of these compounds are likely to enter the colon, where they are deglycosylated by gut microbiota [124]. The gut microbiota has a high hydrolytic potential and ring scission properties so several anthocyanins degradation products have been identified. Some of them include vanillic, phloroglucinol, and protocatechuic acid [124, 125]. For example, incubation of malvidin-3-glucoside (from grape extracts) with fecal bacteria results in formation of gallic, syringic, and p-coumaric acids (Figure 7) (Table 1). Some species responsible for this degradation are Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium lactis [29, 30]. All the anthocyanins and their metabolites tested significantly enhance growth of Bifidobacterium spp., Lactobacillus spp., and Enterococcus spp. Therefore anthocyanins and their metabolites could perform a positive modulation of intestinal bacterial populations [126].


Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.

Marín L, Miguélez EM, Villar CJ, Lombó F - Biomed Res Int (2015)

Colonic degradation of malvidin-3-glucoside, as an example of anthocyanin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352739&req=5

fig7: Colonic degradation of malvidin-3-glucoside, as an example of anthocyanin.
Mentions: Since only a small part of ingested anthocyanins is absorbed at small intestine, large amounts of these compounds are likely to enter the colon, where they are deglycosylated by gut microbiota [124]. The gut microbiota has a high hydrolytic potential and ring scission properties so several anthocyanins degradation products have been identified. Some of them include vanillic, phloroglucinol, and protocatechuic acid [124, 125]. For example, incubation of malvidin-3-glucoside (from grape extracts) with fecal bacteria results in formation of gallic, syringic, and p-coumaric acids (Figure 7) (Table 1). Some species responsible for this degradation are Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium lactis [29, 30]. All the anthocyanins and their metabolites tested significantly enhance growth of Bifidobacterium spp., Lactobacillus spp., and Enterococcus spp. Therefore anthocyanins and their metabolites could perform a positive modulation of intestinal bacterial populations [126].

Bottom Line: Most of them occur as glycosylated derivatives in plants and foods.During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities.This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.

View Article: PubMed Central - PubMed

Affiliation: Research Unit "Biotechnology and Experimental Therapy Based in Nutraceuticals-BITTEN", Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.

ABSTRACT
Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.

No MeSH data available.


Related in: MedlinePlus