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Resveratrol prevents cardiovascular complications in the SHR/STZ rat by reductions in oxidative stress and inflammation.

Vella RK, Pullen C, Coulson FR, Fenning AS - Biomed Res Int (2015)

Bottom Line: This study investigated the ability of resveratrol's antioxidant and anti-inflammatory effects to prevent cardiovascular complications in the spontaneously hypertensive streptozotocin-induced diabetic rat.Resveratrol administration to hypertensive-diabetic animals did not impact upon blood glucose or haemodynamics but significantly reduced oxidative stress, lipid peroxidation, and inflammatory cytokines.This study demonstrates that resveratrol administration to hypertensive diabetic animals can elicit cardioprotective properties via antioxidant and anti-inflammatory effects.

View Article: PubMed Central - PubMed

Affiliation: School of Medical and Applied Sciences, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4701, Australia.

ABSTRACT
The cardioprotective effects of resveratrol are well established in animal models of metabolic disease but are yet to be investigated in a combined model of hypertension and diabetes. This study investigated the ability of resveratrol's antioxidant and anti-inflammatory effects to prevent cardiovascular complications in the spontaneously hypertensive streptozotocin-induced diabetic rat. Diabetes was induced in eight-week-old male spontaneously hypertensive rats via a single intravenous injection of streptozotocin. Following this, resveratrol was administered orally for an eight-week period until the animals were sixteen weeks of age. Upon completion of the treatment regime assessments of oxidative stress, lipid peroxidation, inflammation, and cardiovascular function were made. Resveratrol administration to hypertensive-diabetic animals did not impact upon blood glucose or haemodynamics but significantly reduced oxidative stress, lipid peroxidation, and inflammatory cytokines. Reductions in systemic levels of oxidative stress and inflammation conferred improvements in vascular reactivity and left ventricular pump function and electrophysiology. This study demonstrates that resveratrol administration to hypertensive diabetic animals can elicit cardioprotective properties via antioxidant and anti-inflammatory effects. The observed preservation of cardiovascular function was independent of changes in blood glucose concentration and haemodynamics, suggesting that oxidative stress and inflammation are key components within the pathological cascade associated with hypertension and diabetes.

No MeSH data available.


Related in: MedlinePlus

Cumulative concentration response to acetylcholine of noradrenaline precontracted mesenteric arteries from WKY, WKY + Res, SHR/STZ, and SHR/STZ + Res treated rats. #P < 0.05 versus WKY.
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fig7: Cumulative concentration response to acetylcholine of noradrenaline precontracted mesenteric arteries from WKY, WKY + Res, SHR/STZ, and SHR/STZ + Res treated rats. #P < 0.05 versus WKY.

Mentions: Mesenteric vessels from SHR/STZ animals produced an increased contractile response to noradrenaline that was not altered by resveratrol administration (Figure 6). Neither the onset of hypertension/diabetes nor the administration of resveratrol impacted upon endothelium-independent or endothelium-dependent relaxation responses in resistance arteries (Figures 7 and 8).


Resveratrol prevents cardiovascular complications in the SHR/STZ rat by reductions in oxidative stress and inflammation.

Vella RK, Pullen C, Coulson FR, Fenning AS - Biomed Res Int (2015)

Cumulative concentration response to acetylcholine of noradrenaline precontracted mesenteric arteries from WKY, WKY + Res, SHR/STZ, and SHR/STZ + Res treated rats. #P < 0.05 versus WKY.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352727&req=5

fig7: Cumulative concentration response to acetylcholine of noradrenaline precontracted mesenteric arteries from WKY, WKY + Res, SHR/STZ, and SHR/STZ + Res treated rats. #P < 0.05 versus WKY.
Mentions: Mesenteric vessels from SHR/STZ animals produced an increased contractile response to noradrenaline that was not altered by resveratrol administration (Figure 6). Neither the onset of hypertension/diabetes nor the administration of resveratrol impacted upon endothelium-independent or endothelium-dependent relaxation responses in resistance arteries (Figures 7 and 8).

Bottom Line: This study investigated the ability of resveratrol's antioxidant and anti-inflammatory effects to prevent cardiovascular complications in the spontaneously hypertensive streptozotocin-induced diabetic rat.Resveratrol administration to hypertensive-diabetic animals did not impact upon blood glucose or haemodynamics but significantly reduced oxidative stress, lipid peroxidation, and inflammatory cytokines.This study demonstrates that resveratrol administration to hypertensive diabetic animals can elicit cardioprotective properties via antioxidant and anti-inflammatory effects.

View Article: PubMed Central - PubMed

Affiliation: School of Medical and Applied Sciences, Central Queensland University, Building 81, Bruce Highway, Rockhampton, QLD 4701, Australia.

ABSTRACT
The cardioprotective effects of resveratrol are well established in animal models of metabolic disease but are yet to be investigated in a combined model of hypertension and diabetes. This study investigated the ability of resveratrol's antioxidant and anti-inflammatory effects to prevent cardiovascular complications in the spontaneously hypertensive streptozotocin-induced diabetic rat. Diabetes was induced in eight-week-old male spontaneously hypertensive rats via a single intravenous injection of streptozotocin. Following this, resveratrol was administered orally for an eight-week period until the animals were sixteen weeks of age. Upon completion of the treatment regime assessments of oxidative stress, lipid peroxidation, inflammation, and cardiovascular function were made. Resveratrol administration to hypertensive-diabetic animals did not impact upon blood glucose or haemodynamics but significantly reduced oxidative stress, lipid peroxidation, and inflammatory cytokines. Reductions in systemic levels of oxidative stress and inflammation conferred improvements in vascular reactivity and left ventricular pump function and electrophysiology. This study demonstrates that resveratrol administration to hypertensive diabetic animals can elicit cardioprotective properties via antioxidant and anti-inflammatory effects. The observed preservation of cardiovascular function was independent of changes in blood glucose concentration and haemodynamics, suggesting that oxidative stress and inflammation are key components within the pathological cascade associated with hypertension and diabetes.

No MeSH data available.


Related in: MedlinePlus