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Endothelial dysfunction and cardiovascular disease.

Widmer RJ, Lerman A - Glob Cardiol Sci Pract (2014)

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA.

ABSTRACT

Currently, there are no FDA-approved treatments for endothelial dysfunction, as the treatment should encompass addressing the underlying comorbidity that lead to endothelial dysfunction.

L-arginine, in large quantities (9–18 g daily), has been shown to have beneficial effects on both vascular reactivity and relief of symptoms from coronary endothelial function.

ASA, statins, ACEI have all shown benefit in reducing CVD risk with endothelial function improvement likely to be a concomitant factor.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

No MeSH data available.


Related in: MedlinePlus

Coronary artery vasoreactivity was evalauted in 147 patients with documented coronary heart disease (CHD) or risk factors for CHD; flow-dependent dilation, assessed with intracoronary papaverine or adenosine (upper panel), and flow-independent vasodilation, induced by nitroglycerin (lower panel), were divided into tertiles (percent arterial dilation). During a median follow-up of 6.7 years, impaired vascular reactivity was associated with a significantly higher cardiovascular event rate (cardiovascular death, unstable angina, myocardial infarction, revascularization, stroke, peripheral artery revascularization); the incidence of events was highest in those with the least dilation. Data from Schachinger V, Britten MB, Zeiher AM. Circulation 2000; 101:1899.
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Related In: Results  -  Collection


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fig5: Coronary artery vasoreactivity was evalauted in 147 patients with documented coronary heart disease (CHD) or risk factors for CHD; flow-dependent dilation, assessed with intracoronary papaverine or adenosine (upper panel), and flow-independent vasodilation, induced by nitroglycerin (lower panel), were divided into tertiles (percent arterial dilation). During a median follow-up of 6.7 years, impaired vascular reactivity was associated with a significantly higher cardiovascular event rate (cardiovascular death, unstable angina, myocardial infarction, revascularization, stroke, peripheral artery revascularization); the incidence of events was highest in those with the least dilation. Data from Schachinger V, Britten MB, Zeiher AM. Circulation 2000; 101:1899.

Mentions: Measures of venous endothelial function are used as the pathogenesis of arterial and venous clots share the characteristic of endothelial dysfunction in conditions favorable for generation and as 70% of the circulating blood is contained within the venous system. However, this is seldom used clinically, as the techniques typically involve difficult measures that lack reproducibility such as the dorsal vein technique and radionuclide venous plethysmography. Thus, as patients who will have venous endothelial dysfunction typically have arterial endothelial dysfunction, we suggest using methods mentioned above (Figures 4–6).


Endothelial dysfunction and cardiovascular disease.

Widmer RJ, Lerman A - Glob Cardiol Sci Pract (2014)

Coronary artery vasoreactivity was evalauted in 147 patients with documented coronary heart disease (CHD) or risk factors for CHD; flow-dependent dilation, assessed with intracoronary papaverine or adenosine (upper panel), and flow-independent vasodilation, induced by nitroglycerin (lower panel), were divided into tertiles (percent arterial dilation). During a median follow-up of 6.7 years, impaired vascular reactivity was associated with a significantly higher cardiovascular event rate (cardiovascular death, unstable angina, myocardial infarction, revascularization, stroke, peripheral artery revascularization); the incidence of events was highest in those with the least dilation. Data from Schachinger V, Britten MB, Zeiher AM. Circulation 2000; 101:1899.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352682&req=5

fig5: Coronary artery vasoreactivity was evalauted in 147 patients with documented coronary heart disease (CHD) or risk factors for CHD; flow-dependent dilation, assessed with intracoronary papaverine or adenosine (upper panel), and flow-independent vasodilation, induced by nitroglycerin (lower panel), were divided into tertiles (percent arterial dilation). During a median follow-up of 6.7 years, impaired vascular reactivity was associated with a significantly higher cardiovascular event rate (cardiovascular death, unstable angina, myocardial infarction, revascularization, stroke, peripheral artery revascularization); the incidence of events was highest in those with the least dilation. Data from Schachinger V, Britten MB, Zeiher AM. Circulation 2000; 101:1899.
Mentions: Measures of venous endothelial function are used as the pathogenesis of arterial and venous clots share the characteristic of endothelial dysfunction in conditions favorable for generation and as 70% of the circulating blood is contained within the venous system. However, this is seldom used clinically, as the techniques typically involve difficult measures that lack reproducibility such as the dorsal vein technique and radionuclide venous plethysmography. Thus, as patients who will have venous endothelial dysfunction typically have arterial endothelial dysfunction, we suggest using methods mentioned above (Figures 4–6).

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA.

ABSTRACT

Currently, there are no FDA-approved treatments for endothelial dysfunction, as the treatment should encompass addressing the underlying comorbidity that lead to endothelial dysfunction.

L-arginine, in large quantities (9–18 g daily), has been shown to have beneficial effects on both vascular reactivity and relief of symptoms from coronary endothelial function.

ASA, statins, ACEI have all shown benefit in reducing CVD risk with endothelial function improvement likely to be a concomitant factor.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

No MeSH data available.


Related in: MedlinePlus