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Endothelial dysfunction and cardiovascular disease.

Widmer RJ, Lerman A - Glob Cardiol Sci Pract (2014)

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA.

ABSTRACT

Currently, there are no FDA-approved treatments for endothelial dysfunction, as the treatment should encompass addressing the underlying comorbidity that lead to endothelial dysfunction.

L-arginine, in large quantities (9–18 g daily), has been shown to have beneficial effects on both vascular reactivity and relief of symptoms from coronary endothelial function.

ASA, statins, ACEI have all shown benefit in reducing CVD risk with endothelial function improvement likely to be a concomitant factor.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

No MeSH data available.


Diagram of PAT device on digit.
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fig3: Diagram of PAT device on digit.

Mentions: Peripheral arterial tonometry (PAT) is a technique commonly used to assess microvascular endothelial function via changes in finger pulse wave amplitude in response to reactive hyperemia.88–91 Testing for endothelial function involves the inflation of a blood pressure cuff to supra-systolic pressures. During this process there are two PAT probes connected to the fingers in both arms. The probe that is connected to the arm where the blood pressure cuff is inflated for 5 minutes is used to assess the reactive hyperemic response, a surrogate and a marker for endothelial function. These methodologies are non-invasive, are designed to eliminate environmental interference, and are independent of the subject's knowledge and conscious control of signals generated.88,90 The RH-PAT index is defined as the ratio of the average pulsatile blood volume response, at timed intervals after deflation, to the baseline pulsatile blood volume response; i.e. the average amplitude of the RH-PAT signal over 60 seconds at 1, 2, 3 and 4 minutes after cuff deflation divided by the average amplitude of the RH-PAT signal over 3.5 minutes prior to cuff inflation (during baseline equilibration). A diagram of the PAT device is shown in 3.


Endothelial dysfunction and cardiovascular disease.

Widmer RJ, Lerman A - Glob Cardiol Sci Pract (2014)

Diagram of PAT device on digit.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352682&req=5

fig3: Diagram of PAT device on digit.
Mentions: Peripheral arterial tonometry (PAT) is a technique commonly used to assess microvascular endothelial function via changes in finger pulse wave amplitude in response to reactive hyperemia.88–91 Testing for endothelial function involves the inflation of a blood pressure cuff to supra-systolic pressures. During this process there are two PAT probes connected to the fingers in both arms. The probe that is connected to the arm where the blood pressure cuff is inflated for 5 minutes is used to assess the reactive hyperemic response, a surrogate and a marker for endothelial function. These methodologies are non-invasive, are designed to eliminate environmental interference, and are independent of the subject's knowledge and conscious control of signals generated.88,90 The RH-PAT index is defined as the ratio of the average pulsatile blood volume response, at timed intervals after deflation, to the baseline pulsatile blood volume response; i.e. the average amplitude of the RH-PAT signal over 60 seconds at 1, 2, 3 and 4 minutes after cuff deflation divided by the average amplitude of the RH-PAT signal over 3.5 minutes prior to cuff inflation (during baseline equilibration). A diagram of the PAT device is shown in 3.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA.

ABSTRACT

Currently, there are no FDA-approved treatments for endothelial dysfunction, as the treatment should encompass addressing the underlying comorbidity that lead to endothelial dysfunction.

L-arginine, in large quantities (9–18 g daily), has been shown to have beneficial effects on both vascular reactivity and relief of symptoms from coronary endothelial function.

ASA, statins, ACEI have all shown benefit in reducing CVD risk with endothelial function improvement likely to be a concomitant factor.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

No MeSH data available.