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Endothelial dysfunction and cardiovascular disease.

Widmer RJ, Lerman A - Glob Cardiol Sci Pract (2014)

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA.

ABSTRACT

Currently, there are no FDA-approved treatments for endothelial dysfunction, as the treatment should encompass addressing the underlying comorbidity that lead to endothelial dysfunction.

L-arginine, in large quantities (9–18 g daily), has been shown to have beneficial effects on both vascular reactivity and relief of symptoms from coronary endothelial function.

ASA, statins, ACEI have all shown benefit in reducing CVD risk with endothelial function improvement likely to be a concomitant factor.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

No MeSH data available.


Related in: MedlinePlus

Coronary vasoreactivity and atherosclerotic disease progression. Top left shows baseline coronary angiogram of a patient in whom focal paradoxical vasoconstriction to acetylcholine occurred in the proximal left anterior descending artery (top right) at the time of the initial vasomotor testing (arrow indicates tip of acetylcholine infusion catheter). Injection of nitroglycerin (bottom left) demonstrates only minimal vasodilation and unmasks an atherosclerotic plaque at the site of paradoxical vasoconstriction to acetylcholine. During follow-up 3.7 years later, the patient was admitted to the hospital with an acute coronary syndrome. Coronary angiography revealed focal progression of atherosclerotic disease (bottom right) at the site of the initial paradoxical vasoconstriction to acetylcholine.
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fig1: Coronary vasoreactivity and atherosclerotic disease progression. Top left shows baseline coronary angiogram of a patient in whom focal paradoxical vasoconstriction to acetylcholine occurred in the proximal left anterior descending artery (top right) at the time of the initial vasomotor testing (arrow indicates tip of acetylcholine infusion catheter). Injection of nitroglycerin (bottom left) demonstrates only minimal vasodilation and unmasks an atherosclerotic plaque at the site of paradoxical vasoconstriction to acetylcholine. During follow-up 3.7 years later, the patient was admitted to the hospital with an acute coronary syndrome. Coronary angiography revealed focal progression of atherosclerotic disease (bottom right) at the site of the initial paradoxical vasoconstriction to acetylcholine.

Mentions: Impedance plethysmography is a method of assessing endothelial function via strain-gauge venous impedance plethysmography which examines the changes in forearm blood flow in response to direct intravascular administration of vascular agonists.81 Due to the invasive nature of this test it is primarily used in research settings, and rarely utilized clinically (Figures 1,2).


Endothelial dysfunction and cardiovascular disease.

Widmer RJ, Lerman A - Glob Cardiol Sci Pract (2014)

Coronary vasoreactivity and atherosclerotic disease progression. Top left shows baseline coronary angiogram of a patient in whom focal paradoxical vasoconstriction to acetylcholine occurred in the proximal left anterior descending artery (top right) at the time of the initial vasomotor testing (arrow indicates tip of acetylcholine infusion catheter). Injection of nitroglycerin (bottom left) demonstrates only minimal vasodilation and unmasks an atherosclerotic plaque at the site of paradoxical vasoconstriction to acetylcholine. During follow-up 3.7 years later, the patient was admitted to the hospital with an acute coronary syndrome. Coronary angiography revealed focal progression of atherosclerotic disease (bottom right) at the site of the initial paradoxical vasoconstriction to acetylcholine.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352682&req=5

fig1: Coronary vasoreactivity and atherosclerotic disease progression. Top left shows baseline coronary angiogram of a patient in whom focal paradoxical vasoconstriction to acetylcholine occurred in the proximal left anterior descending artery (top right) at the time of the initial vasomotor testing (arrow indicates tip of acetylcholine infusion catheter). Injection of nitroglycerin (bottom left) demonstrates only minimal vasodilation and unmasks an atherosclerotic plaque at the site of paradoxical vasoconstriction to acetylcholine. During follow-up 3.7 years later, the patient was admitted to the hospital with an acute coronary syndrome. Coronary angiography revealed focal progression of atherosclerotic disease (bottom right) at the site of the initial paradoxical vasoconstriction to acetylcholine.
Mentions: Impedance plethysmography is a method of assessing endothelial function via strain-gauge venous impedance plethysmography which examines the changes in forearm blood flow in response to direct intravascular administration of vascular agonists.81 Due to the invasive nature of this test it is primarily used in research settings, and rarely utilized clinically (Figures 1,2).

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA.

ABSTRACT

Currently, there are no FDA-approved treatments for endothelial dysfunction, as the treatment should encompass addressing the underlying comorbidity that lead to endothelial dysfunction.

L-arginine, in large quantities (9–18 g daily), has been shown to have beneficial effects on both vascular reactivity and relief of symptoms from coronary endothelial function.

ASA, statins, ACEI have all shown benefit in reducing CVD risk with endothelial function improvement likely to be a concomitant factor.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

Diet and exercise have both been shown to improve vascular reactivity, and should be encouraged as part of lifestyle behaviors beneficial toward overall CVD health.

No MeSH data available.


Related in: MedlinePlus