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Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck.

Rades D, Huttenlocher S, Seibold ND, Gebhard MP, Thorns C, Hasselbacher K, Wollenberg B, Schild SE - BMC Cancer (2015)

Bottom Line: Univariate analyses were performed with Kaplan-Meier method and log-rank test, multivariate analyses with Cox proportional hazards model.On univariate analyses, p65-expression had a significant impact on OS (p < 0.001) and LRC (p < 0.001) but not on MFS (p = 0.29).P65-negativity was significantly associated with improved LRC and achieved borderline significance with respect to improved OS.

View Article: PubMed Central - PubMed

ABSTRACT

Background: This study investigated the prognostic role of nuclear expression of p65 in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) receiving post-operative radio(chemo)therapy.

Methods: Nuclear p65-expression (H-score ≤50 versus >50) plus twelve characteristics were analyzed in 151 patients for overall survival (OS), metastases-free survival (MFS) and loco-regional control (LRC). Additional characteristics included age, gender, Karnofsky performance score (KPS), pre-radiotherapy hemoglobin levels, tumor site, histological grading, human papilloma virus (HPV)-status, T-classification, N-classification, American Joint Committee on Cancer (AJCC)-stage, extent of resection and concurrent chemotherapy. Univariate analyses were performed with Kaplan-Meier method and log-rank test, multivariate analyses with Cox proportional hazards model.

Results: On univariate analyses, p65-expression had a significant impact on OS (p < 0.001) and LRC (p < 0.001) but not on MFS (p = 0.29). On multivariate analysis, KPS ≥80 (risk ratio [RR] 2.23; p = 0.012), HPV-positivity (RR 5.83; p = 0.020), T1-T2 (RR 1.38; p = 0.048), N0-N2a (RR 2.72; p = 0.005) and complete resection (RR 2.02; p = 0.049) were positively associated with OS; p65-negativity achieved borderline significance (RR 3.02; p = 0.052). Better MFS was associated with KPS ≥80 (RR 2.49; p = 0.015), T1-T2 (RR: 1.74; p = 0.005), N0-N2a (RR: 6.22; p < 0.001) and complete resection (RR 3.43; p = 0.003). Positive associations with LRC were found for p65-negativity (RR 5.06; p = 0.008), T1-T2 (RR: 1.49; p = 0.022), N0-N2a (RR: 2.97; p = 0.004) and favorable tumor site (RR 1.28; p = 0.025).

Conclusions: P65-negativity was significantly associated with improved LRC and achieved borderline significance with respect to improved OS. Thus, p65-expression may be an additional target for novel agents in the treatment of locally advanced SCCHN.

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Impact of p65-expression on overall survival (top), metastases-free survival (middle) and loco-regional control (bottom).
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Fig2: Impact of p65-expression on overall survival (top), metastases-free survival (middle) and loco-regional control (bottom).

Mentions: On univariate analyses of MFS (Table 3), a positive impact was found for KPS ≥80 (p = 0.049), favorable tumor site (oropharynx or larynx cancer; p = 0.036), T-classification 1–2 (p = 0.013), N-classification 0-2a (p = 0.004), AJCC-stage III (p = 0.011) and complete resection (p = 0.002). HPV-positivity showed a trend towards improved MFS (p = 0.09). P65-expression was not significantly associated with MFS (Figure 2, p = 0.29). In the corresponding multivariate analysis (performed without AJCC-stage), KPS (RR 2.49; 95%-CI 1.19-5.29; p = 0.015), T-classification (RR: 1.74; 95%-CI: 1.18-2.64; p = 0.005), N-classification (RR: 6.22; 95%-CI: 2.34-21.56; p < 0.001) and extent of resection (RR 3.43; 95%-CI 1.54-7.34; p = 0.003) were significant; tumor site (RR: 1.13; 95%-CI: 0.88-1.43; p = 0.34) was not significant.Table 3


Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck.

Rades D, Huttenlocher S, Seibold ND, Gebhard MP, Thorns C, Hasselbacher K, Wollenberg B, Schild SE - BMC Cancer (2015)

Impact of p65-expression on overall survival (top), metastases-free survival (middle) and loco-regional control (bottom).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4352566&req=5

Fig2: Impact of p65-expression on overall survival (top), metastases-free survival (middle) and loco-regional control (bottom).
Mentions: On univariate analyses of MFS (Table 3), a positive impact was found for KPS ≥80 (p = 0.049), favorable tumor site (oropharynx or larynx cancer; p = 0.036), T-classification 1–2 (p = 0.013), N-classification 0-2a (p = 0.004), AJCC-stage III (p = 0.011) and complete resection (p = 0.002). HPV-positivity showed a trend towards improved MFS (p = 0.09). P65-expression was not significantly associated with MFS (Figure 2, p = 0.29). In the corresponding multivariate analysis (performed without AJCC-stage), KPS (RR 2.49; 95%-CI 1.19-5.29; p = 0.015), T-classification (RR: 1.74; 95%-CI: 1.18-2.64; p = 0.005), N-classification (RR: 6.22; 95%-CI: 2.34-21.56; p < 0.001) and extent of resection (RR 3.43; 95%-CI 1.54-7.34; p = 0.003) were significant; tumor site (RR: 1.13; 95%-CI: 0.88-1.43; p = 0.34) was not significant.Table 3

Bottom Line: Univariate analyses were performed with Kaplan-Meier method and log-rank test, multivariate analyses with Cox proportional hazards model.On univariate analyses, p65-expression had a significant impact on OS (p < 0.001) and LRC (p < 0.001) but not on MFS (p = 0.29).P65-negativity was significantly associated with improved LRC and achieved borderline significance with respect to improved OS.

View Article: PubMed Central - PubMed

ABSTRACT

Background: This study investigated the prognostic role of nuclear expression of p65 in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) receiving post-operative radio(chemo)therapy.

Methods: Nuclear p65-expression (H-score ≤50 versus >50) plus twelve characteristics were analyzed in 151 patients for overall survival (OS), metastases-free survival (MFS) and loco-regional control (LRC). Additional characteristics included age, gender, Karnofsky performance score (KPS), pre-radiotherapy hemoglobin levels, tumor site, histological grading, human papilloma virus (HPV)-status, T-classification, N-classification, American Joint Committee on Cancer (AJCC)-stage, extent of resection and concurrent chemotherapy. Univariate analyses were performed with Kaplan-Meier method and log-rank test, multivariate analyses with Cox proportional hazards model.

Results: On univariate analyses, p65-expression had a significant impact on OS (p < 0.001) and LRC (p < 0.001) but not on MFS (p = 0.29). On multivariate analysis, KPS ≥80 (risk ratio [RR] 2.23; p = 0.012), HPV-positivity (RR 5.83; p = 0.020), T1-T2 (RR 1.38; p = 0.048), N0-N2a (RR 2.72; p = 0.005) and complete resection (RR 2.02; p = 0.049) were positively associated with OS; p65-negativity achieved borderline significance (RR 3.02; p = 0.052). Better MFS was associated with KPS ≥80 (RR 2.49; p = 0.015), T1-T2 (RR: 1.74; p = 0.005), N0-N2a (RR: 6.22; p < 0.001) and complete resection (RR 3.43; p = 0.003). Positive associations with LRC were found for p65-negativity (RR 5.06; p = 0.008), T1-T2 (RR: 1.49; p = 0.022), N0-N2a (RR: 2.97; p = 0.004) and favorable tumor site (RR 1.28; p = 0.025).

Conclusions: P65-negativity was significantly associated with improved LRC and achieved borderline significance with respect to improved OS. Thus, p65-expression may be an additional target for novel agents in the treatment of locally advanced SCCHN.

Show MeSH
Related in: MedlinePlus