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Renal effects of Anchomanes difformis crude extract in wistar rats.

Ataman E J, Idu M - Avicenna J Phytomed (2015 Jan-Feb)

Bottom Line: The kidneys of the experimental animals were histologically examined for morphologic changes.RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control.The current study results suggest renal toxicity with excessive consumption of A.difformis.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Benin, PMB 1154, Benin City, Nigeria.

ABSTRACT

Objective: Anchomanes difformis is a member of the plant family Araceae which is used as a diuretic but also has other medicinal applications. This study investigates the dietary effects of A. difformis on the kidneys of adult wistar rats.

Materials and methods: Sixteen rats were used and were weighed, before and after the experiment. All rats were randomly divided into four groups. All groups were treated with the following regimen for two weeks. The control group (A) was fed on feed mash and water ad libitum throughout the period. The treatment groups B, C, and D received feed mash mixed with crude extract of A. difformis in the following proportions: 25:75(g), 50:50(g), and 75:25(g), respectively. The kidneys of the experimental animals were histologically examined for morphologic changes.

Results: RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control. Histological examination of the renal tissues also showed considerable lesions such as inflammation, focal cortical and interstitial hemorrhage, and fibrosis in the treated rats compared with the control.

Conclusion: The current study results suggest renal toxicity with excessive consumption of A.difformis.

No MeSH data available.


Related in: MedlinePlus

Section of group B Male (BM) kidney with severe focal interstitial hemorrhage (a) and oedema (b) [H&E x100].
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Figure 4: Section of group B Male (BM) kidney with severe focal interstitial hemorrhage (a) and oedema (b) [H&E x100].

Mentions: The photomicrographs of the kidney of the rats in the treatment group B that received the highest dose of crude extract of A. difformis revealed areas of moderate focal interstitial fibrosis, hemorrhage, severe focal perivascular inflammation and vascular hypertrophy (Fig. 3), severe focal interstitial hemorrhage and edema (Figure 4), and also severe focal interstitial fibrosis and dilated and hypertrophic blood vessel (Figure 5). The micrographs of the kidney of the rats in treatment group C that received moderate dose of the crude extract of A. difformis, showed kidney with severe focal cortical and interstitial hemorrhage (Figure 6), severe focal interstitial fibrosis, and mild inflammation (Figure 7). The micrographs of the kidney of the rats in treatment group D that received the lowest dose of the crude extract of A. difformis, showed kidney with focal interstitial fibrosis, vascular hypertrophy, and severe focal inflammation (Figure 8)


Renal effects of Anchomanes difformis crude extract in wistar rats.

Ataman E J, Idu M - Avicenna J Phytomed (2015 Jan-Feb)

Section of group B Male (BM) kidney with severe focal interstitial hemorrhage (a) and oedema (b) [H&E x100].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352529&req=5

Figure 4: Section of group B Male (BM) kidney with severe focal interstitial hemorrhage (a) and oedema (b) [H&E x100].
Mentions: The photomicrographs of the kidney of the rats in the treatment group B that received the highest dose of crude extract of A. difformis revealed areas of moderate focal interstitial fibrosis, hemorrhage, severe focal perivascular inflammation and vascular hypertrophy (Fig. 3), severe focal interstitial hemorrhage and edema (Figure 4), and also severe focal interstitial fibrosis and dilated and hypertrophic blood vessel (Figure 5). The micrographs of the kidney of the rats in treatment group C that received moderate dose of the crude extract of A. difformis, showed kidney with severe focal cortical and interstitial hemorrhage (Figure 6), severe focal interstitial fibrosis, and mild inflammation (Figure 7). The micrographs of the kidney of the rats in treatment group D that received the lowest dose of the crude extract of A. difformis, showed kidney with focal interstitial fibrosis, vascular hypertrophy, and severe focal inflammation (Figure 8)

Bottom Line: The kidneys of the experimental animals were histologically examined for morphologic changes.RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control.The current study results suggest renal toxicity with excessive consumption of A.difformis.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Benin, PMB 1154, Benin City, Nigeria.

ABSTRACT

Objective: Anchomanes difformis is a member of the plant family Araceae which is used as a diuretic but also has other medicinal applications. This study investigates the dietary effects of A. difformis on the kidneys of adult wistar rats.

Materials and methods: Sixteen rats were used and were weighed, before and after the experiment. All rats were randomly divided into four groups. All groups were treated with the following regimen for two weeks. The control group (A) was fed on feed mash and water ad libitum throughout the period. The treatment groups B, C, and D received feed mash mixed with crude extract of A. difformis in the following proportions: 25:75(g), 50:50(g), and 75:25(g), respectively. The kidneys of the experimental animals were histologically examined for morphologic changes.

Results: RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control. Histological examination of the renal tissues also showed considerable lesions such as inflammation, focal cortical and interstitial hemorrhage, and fibrosis in the treated rats compared with the control.

Conclusion: The current study results suggest renal toxicity with excessive consumption of A.difformis.

No MeSH data available.


Related in: MedlinePlus