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Renal effects of Anchomanes difformis crude extract in wistar rats.

Ataman E J, Idu M - Avicenna J Phytomed (2015 Jan-Feb)

Bottom Line: The kidneys of the experimental animals were histologically examined for morphologic changes.RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control.The current study results suggest renal toxicity with excessive consumption of A.difformis.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Benin, PMB 1154, Benin City, Nigeria.

ABSTRACT

Objective: Anchomanes difformis is a member of the plant family Araceae which is used as a diuretic but also has other medicinal applications. This study investigates the dietary effects of A. difformis on the kidneys of adult wistar rats.

Materials and methods: Sixteen rats were used and were weighed, before and after the experiment. All rats were randomly divided into four groups. All groups were treated with the following regimen for two weeks. The control group (A) was fed on feed mash and water ad libitum throughout the period. The treatment groups B, C, and D received feed mash mixed with crude extract of A. difformis in the following proportions: 25:75(g), 50:50(g), and 75:25(g), respectively. The kidneys of the experimental animals were histologically examined for morphologic changes.

Results: RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control. Histological examination of the renal tissues also showed considerable lesions such as inflammation, focal cortical and interstitial hemorrhage, and fibrosis in the treated rats compared with the control.

Conclusion: The current study results suggest renal toxicity with excessive consumption of A.difformis.

No MeSH data available.


Related in: MedlinePlus

Anchomanes difformis (Blume) Engl. Pallidus.
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Figure 1: Anchomanes difformis (Blume) Engl. Pallidus.

Mentions: Anchomanes difformis (Blume) Engl. Pallidus, commonly known as forest anchomanes is a plant of the family Araceae. A. difformis is a native plant of the African continent and grows widely in wetlands and terrestrial areas of West Tropical Africa including Nigeria, Ghana, Ivory Coast, Sierra Leone, Senegal, and Togo. A. difformis is a large herbaceous perennial plant with stout prickly stem (leaf petioles) of about 0.8 to 2 m high. The plant is erect on an enormous horizontal tuber, often reaching 50 to 80 cm long and 10 to 20 cm in diameter (Figure 1). It usually contains milky or watery latex, which is rarely colored. In Nigeria, A. difformis is locally called Olikhoror by the Bini tribe of Edo State. Despite of the toxic effects of Araceae, species of several genera are also cultivated as food plants, mainly as subsistence crops in the tropical areas. The major edible Araceae are Colocasia esculenta and several species of Xanthosoma, grown primarily for their corms and sometimes for their leaves. Most of the North American species of Araceae were historically used by the native Americans, as both food and medicine (Plowman, 1969 ▶). Further, claims from earlier report is that its leaves, stem, and roots (rhizomes) serve as food and are believed to sub-serve medicinal properties (Dalziel, 1937 ▶).


Renal effects of Anchomanes difformis crude extract in wistar rats.

Ataman E J, Idu M - Avicenna J Phytomed (2015 Jan-Feb)

Anchomanes difformis (Blume) Engl. Pallidus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352529&req=5

Figure 1: Anchomanes difformis (Blume) Engl. Pallidus.
Mentions: Anchomanes difformis (Blume) Engl. Pallidus, commonly known as forest anchomanes is a plant of the family Araceae. A. difformis is a native plant of the African continent and grows widely in wetlands and terrestrial areas of West Tropical Africa including Nigeria, Ghana, Ivory Coast, Sierra Leone, Senegal, and Togo. A. difformis is a large herbaceous perennial plant with stout prickly stem (leaf petioles) of about 0.8 to 2 m high. The plant is erect on an enormous horizontal tuber, often reaching 50 to 80 cm long and 10 to 20 cm in diameter (Figure 1). It usually contains milky or watery latex, which is rarely colored. In Nigeria, A. difformis is locally called Olikhoror by the Bini tribe of Edo State. Despite of the toxic effects of Araceae, species of several genera are also cultivated as food plants, mainly as subsistence crops in the tropical areas. The major edible Araceae are Colocasia esculenta and several species of Xanthosoma, grown primarily for their corms and sometimes for their leaves. Most of the North American species of Araceae were historically used by the native Americans, as both food and medicine (Plowman, 1969 ▶). Further, claims from earlier report is that its leaves, stem, and roots (rhizomes) serve as food and are believed to sub-serve medicinal properties (Dalziel, 1937 ▶).

Bottom Line: The kidneys of the experimental animals were histologically examined for morphologic changes.RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control.The current study results suggest renal toxicity with excessive consumption of A.difformis.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Benin, PMB 1154, Benin City, Nigeria.

ABSTRACT

Objective: Anchomanes difformis is a member of the plant family Araceae which is used as a diuretic but also has other medicinal applications. This study investigates the dietary effects of A. difformis on the kidneys of adult wistar rats.

Materials and methods: Sixteen rats were used and were weighed, before and after the experiment. All rats were randomly divided into four groups. All groups were treated with the following regimen for two weeks. The control group (A) was fed on feed mash and water ad libitum throughout the period. The treatment groups B, C, and D received feed mash mixed with crude extract of A. difformis in the following proportions: 25:75(g), 50:50(g), and 75:25(g), respectively. The kidneys of the experimental animals were histologically examined for morphologic changes.

Results: RESULTS showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control. Histological examination of the renal tissues also showed considerable lesions such as inflammation, focal cortical and interstitial hemorrhage, and fibrosis in the treated rats compared with the control.

Conclusion: The current study results suggest renal toxicity with excessive consumption of A.difformis.

No MeSH data available.


Related in: MedlinePlus