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Non surgical treatment of sacral osteosarcoma.

Aledavood SA, Amirabadi A, Memar B - Iran J Cancer Prev (2012)

Bottom Line: In some pelvic and most vertebral primary tumors, resection often is not possible completely.This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy.In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research Center , Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT
Osteosarcoma may rarely originate from the axial bones such as pelvis or vertebrae. In some pelvic and most vertebral primary tumors, resection often is not possible completely. In general, these tumors cannot be resected with negative margins so they need additional radiotherapy and chemotherapy, but results are unfavourable because of poor local control and high incidence of distant metastases. This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy. The patient is a 14-year-old boy with a large osteosarcoma tumor in the first sacral vertebral body, with extra skeletal extension. The patient took radiotherapy (6000 centigray) plus chemotherapy regimen consisting of doxorubicin and cisplatin. In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

No MeSH data available.


Related in: MedlinePlus

Neoplastic bone formation and reticulated woven bone
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f2-IJCP-05-046: Neoplastic bone formation and reticulated woven bone

Mentions: Open biopsy of the lesion was done and pathologic study performed. In microscopic evaluation sarcomatous neoplasm was seen with foci of tumoral ossification composed of branching woven bone trabeculas as well as foci of poorly differentiated hyper cellular regions and extensive areas of chondroblastic differentiation with small areas of mixoid tissues. Grading of tumor was estimated 2 out of 4 and final pathologic diagnosis was chondroblastic osteosarcoma grade 2 (Figure 2).


Non surgical treatment of sacral osteosarcoma.

Aledavood SA, Amirabadi A, Memar B - Iran J Cancer Prev (2012)

Neoplastic bone formation and reticulated woven bone
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352526&req=5

f2-IJCP-05-046: Neoplastic bone formation and reticulated woven bone
Mentions: Open biopsy of the lesion was done and pathologic study performed. In microscopic evaluation sarcomatous neoplasm was seen with foci of tumoral ossification composed of branching woven bone trabeculas as well as foci of poorly differentiated hyper cellular regions and extensive areas of chondroblastic differentiation with small areas of mixoid tissues. Grading of tumor was estimated 2 out of 4 and final pathologic diagnosis was chondroblastic osteosarcoma grade 2 (Figure 2).

Bottom Line: In some pelvic and most vertebral primary tumors, resection often is not possible completely.This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy.In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research Center , Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT
Osteosarcoma may rarely originate from the axial bones such as pelvis or vertebrae. In some pelvic and most vertebral primary tumors, resection often is not possible completely. In general, these tumors cannot be resected with negative margins so they need additional radiotherapy and chemotherapy, but results are unfavourable because of poor local control and high incidence of distant metastases. This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy. The patient is a 14-year-old boy with a large osteosarcoma tumor in the first sacral vertebral body, with extra skeletal extension. The patient took radiotherapy (6000 centigray) plus chemotherapy regimen consisting of doxorubicin and cisplatin. In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

No MeSH data available.


Related in: MedlinePlus