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Non surgical treatment of sacral osteosarcoma.

Aledavood SA, Amirabadi A, Memar B - Iran J Cancer Prev (2012)

Bottom Line: In some pelvic and most vertebral primary tumors, resection often is not possible completely.This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy.In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research Center , Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT
Osteosarcoma may rarely originate from the axial bones such as pelvis or vertebrae. In some pelvic and most vertebral primary tumors, resection often is not possible completely. In general, these tumors cannot be resected with negative margins so they need additional radiotherapy and chemotherapy, but results are unfavourable because of poor local control and high incidence of distant metastases. This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy. The patient is a 14-year-old boy with a large osteosarcoma tumor in the first sacral vertebral body, with extra skeletal extension. The patient took radiotherapy (6000 centigray) plus chemotherapy regimen consisting of doxorubicin and cisplatin. In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

No MeSH data available.


Related in: MedlinePlus

Sagital view MRI scan of lower vertebral column
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f1-IJCP-05-046: Sagital view MRI scan of lower vertebral column

Mentions: A 14-years-old boy came with pain in lower lumbar region lasting for 5 months. One month before presentation, pain had referred to right thigh. He also complained of mild anorexia and weigh loss of about 3 kg. There were no gastrointestinal symptoms, fever and sweating in that period. Physical examinations revealed that he suffered only mild to moderate tenderness on sacral region with a very mild bulging with firm consistency. Muscular force in the proximal of lower extremities was normal while there was a moderate weakness in left foot muscles. Plain radiography of the pelvis and lumbosacral region revealed a large sclerotic lesion with ill defined borders in the first sacral vertebral body, with extra skeletal extension. MRI of this region revealed a large destructing bone lesion in sacrum (Figure 1).


Non surgical treatment of sacral osteosarcoma.

Aledavood SA, Amirabadi A, Memar B - Iran J Cancer Prev (2012)

Sagital view MRI scan of lower vertebral column
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352526&req=5

f1-IJCP-05-046: Sagital view MRI scan of lower vertebral column
Mentions: A 14-years-old boy came with pain in lower lumbar region lasting for 5 months. One month before presentation, pain had referred to right thigh. He also complained of mild anorexia and weigh loss of about 3 kg. There were no gastrointestinal symptoms, fever and sweating in that period. Physical examinations revealed that he suffered only mild to moderate tenderness on sacral region with a very mild bulging with firm consistency. Muscular force in the proximal of lower extremities was normal while there was a moderate weakness in left foot muscles. Plain radiography of the pelvis and lumbosacral region revealed a large sclerotic lesion with ill defined borders in the first sacral vertebral body, with extra skeletal extension. MRI of this region revealed a large destructing bone lesion in sacrum (Figure 1).

Bottom Line: In some pelvic and most vertebral primary tumors, resection often is not possible completely.This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy.In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research Center , Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT
Osteosarcoma may rarely originate from the axial bones such as pelvis or vertebrae. In some pelvic and most vertebral primary tumors, resection often is not possible completely. In general, these tumors cannot be resected with negative margins so they need additional radiotherapy and chemotherapy, but results are unfavourable because of poor local control and high incidence of distant metastases. This is a case report of sacral osteosarcoma which was treated successfully with chemotherapy and radiation therapy. The patient is a 14-year-old boy with a large osteosarcoma tumor in the first sacral vertebral body, with extra skeletal extension. The patient took radiotherapy (6000 centigray) plus chemotherapy regimen consisting of doxorubicin and cisplatin. In the last follow up 48 months later, the patient was completely asymptomatic with normal performance and there was not any evidence of local progression or distant metastasis.

No MeSH data available.


Related in: MedlinePlus