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Beneficial effects and safety of corticosteroids combined with traditional chinese medicine for pemphigus: a systematic review.

Zhou T, Zhou P, Hua H, Liu X - Evid Based Complement Alternat Med (2015)

Bottom Line: Methods.Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ) level.The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China.

ABSTRACT
Objective. To evaluate the beneficial effects and safety of corticosteroids combined with traditional Chinese medicine (TCM) for pemphigus. Methods. Seven electronic databases were searched to identify any potential randomized controlled trials (RCTs) or clinical controlled trials (CCTs) that compared corticosteroids with and without TCM for the treatment of pemphigus, published in any language. Remission of the mucocutaneous lesions, therapeutic duration, dosage of corticosteroids, and specific antibody titers were employed as the main outcome measures. The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and Rev Man 5.1.0 software. Results. Four RCTs with a total of 199 patients were included in the present review. Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ) level. The trials were not of high methodological quality. No study mentioned allocation concealment and blinding. Only one trial reported adverse events, and it indicated that the safety of corticosteroids combined with TCM was uncertain. Conclusion. There is some, albeit weak, evidence to show that combined treatment with corticosteroids with TCM could be of benefit for some patients with pemphigus. The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.

No MeSH data available.


Related in: MedlinePlus

Study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Study selection process.

Mentions: A total of 450 abstracts (431 in Chinese and 19 in English) were obtained from 9 databases and were evaluated on the basis of the inclusion criteria of the present analysis. Figure 1 shows details regarding the full flow of information, presented according to the PRISMA format [13]. A total of 193 studies were excluded for duplication. Among the 257 remaining abstracts, 106 abstracts were not relevant, and 42 described bullous disorders other than pemphigus. Therefore, 10 full-text articles were reviewed. Further examination showed that only four trials met the inclusion criteria; they were included in the present analysis [6, 14–16].


Beneficial effects and safety of corticosteroids combined with traditional chinese medicine for pemphigus: a systematic review.

Zhou T, Zhou P, Hua H, Liu X - Evid Based Complement Alternat Med (2015)

Study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352514&req=5

fig1: Study selection process.
Mentions: A total of 450 abstracts (431 in Chinese and 19 in English) were obtained from 9 databases and were evaluated on the basis of the inclusion criteria of the present analysis. Figure 1 shows details regarding the full flow of information, presented according to the PRISMA format [13]. A total of 193 studies were excluded for duplication. Among the 257 remaining abstracts, 106 abstracts were not relevant, and 42 described bullous disorders other than pemphigus. Therefore, 10 full-text articles were reviewed. Further examination showed that only four trials met the inclusion criteria; they were included in the present analysis [6, 14–16].

Bottom Line: Methods.Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ) level.The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China.

ABSTRACT
Objective. To evaluate the beneficial effects and safety of corticosteroids combined with traditional Chinese medicine (TCM) for pemphigus. Methods. Seven electronic databases were searched to identify any potential randomized controlled trials (RCTs) or clinical controlled trials (CCTs) that compared corticosteroids with and without TCM for the treatment of pemphigus, published in any language. Remission of the mucocutaneous lesions, therapeutic duration, dosage of corticosteroids, and specific antibody titers were employed as the main outcome measures. The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and Rev Man 5.1.0 software. Results. Four RCTs with a total of 199 patients were included in the present review. Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ) level. The trials were not of high methodological quality. No study mentioned allocation concealment and blinding. Only one trial reported adverse events, and it indicated that the safety of corticosteroids combined with TCM was uncertain. Conclusion. There is some, albeit weak, evidence to show that combined treatment with corticosteroids with TCM could be of benefit for some patients with pemphigus. The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.

No MeSH data available.


Related in: MedlinePlus