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Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response.

Townsend JR, Hoffman JR, Gonzalez AM, Jajtner AR, Boone CH, Robinson EH, Mangine GT, Wells AJ, Fragala MS, Fukuda DH, Stout JR - Int J Endocrinol (2015)

Bottom Line: A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01).Conclusion.These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

View Article: PubMed Central - PubMed

Affiliation: Institute of Exercise Science and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL 32816, USA.

ABSTRACT
Objective. To examine the endocrine response to a bout of heavy resistance exercise following acute β-hydroxy-β-methylbutyrate free acid (HMB-FA) ingestion. Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule. Results. The resistance exercise protocol resulted in significant elevations from PRE in testosterone (P < 0.01), GH (P < 0.01), and insulin (P = 0.05) at IP, with GH (P < 0.01) and insulin (P < 0.01) remaining elevated at 30P. A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01). AUC analysis revealed an elevated GH and IGF-1 response in the HMB-FA group compared to PL. Conclusion. HMB-FA prior to resistance exercise augments the GH response to high volume resistance exercise compared to PL. These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

No MeSH data available.


Related in: MedlinePlus

(a) Serum insulin concentration values for placebo (PL) and β-hydroxy-β-methylbutyrate free acid (HMB-FA) groups before exercise (PRE), immediately after exercise (IP), and 30 minutes after exercise (30P).  *Both groups significantly elevated from PRE (P ≤ 0.01). (b) Area under the curve (AUC) analysis for serum insulin levels for PL and HMB-FA groups. Data were reported as mean ± SD.
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fig4: (a) Serum insulin concentration values for placebo (PL) and β-hydroxy-β-methylbutyrate free acid (HMB-FA) groups before exercise (PRE), immediately after exercise (IP), and 30 minutes after exercise (30P).  *Both groups significantly elevated from PRE (P ≤ 0.01). (b) Area under the curve (AUC) analysis for serum insulin levels for PL and HMB-FA groups. Data were reported as mean ± SD.

Mentions: Changes in insulin concentrations can be observed in Figures 4(a) and 4(b). Increases from PRE were observed in both groups at IP (P = 0.008) and 30P (P = 0.015), but no differences were observed between the groups. Figure 4(b) depicts the AUC analysis on the insulin response during the exercise protocol. No difference (P ≤ 0.92) was observed between HMB-FA and PL.


Effects of β-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response.

Townsend JR, Hoffman JR, Gonzalez AM, Jajtner AR, Boone CH, Robinson EH, Mangine GT, Wells AJ, Fragala MS, Fukuda DH, Stout JR - Int J Endocrinol (2015)

(a) Serum insulin concentration values for placebo (PL) and β-hydroxy-β-methylbutyrate free acid (HMB-FA) groups before exercise (PRE), immediately after exercise (IP), and 30 minutes after exercise (30P).  *Both groups significantly elevated from PRE (P ≤ 0.01). (b) Area under the curve (AUC) analysis for serum insulin levels for PL and HMB-FA groups. Data were reported as mean ± SD.
© Copyright Policy - open-access
Related In: Results  -  Collection

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fig4: (a) Serum insulin concentration values for placebo (PL) and β-hydroxy-β-methylbutyrate free acid (HMB-FA) groups before exercise (PRE), immediately after exercise (IP), and 30 minutes after exercise (30P).  *Both groups significantly elevated from PRE (P ≤ 0.01). (b) Area under the curve (AUC) analysis for serum insulin levels for PL and HMB-FA groups. Data were reported as mean ± SD.
Mentions: Changes in insulin concentrations can be observed in Figures 4(a) and 4(b). Increases from PRE were observed in both groups at IP (P = 0.008) and 30P (P = 0.015), but no differences were observed between the groups. Figure 4(b) depicts the AUC analysis on the insulin response during the exercise protocol. No difference (P ≤ 0.92) was observed between HMB-FA and PL.

Bottom Line: A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01).Conclusion.These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

View Article: PubMed Central - PubMed

Affiliation: Institute of Exercise Science and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, FL 32816, USA.

ABSTRACT
Objective. To examine the endocrine response to a bout of heavy resistance exercise following acute β-hydroxy-β-methylbutyrate free acid (HMB-FA) ingestion. Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule. Results. The resistance exercise protocol resulted in significant elevations from PRE in testosterone (P < 0.01), GH (P < 0.01), and insulin (P = 0.05) at IP, with GH (P < 0.01) and insulin (P < 0.01) remaining elevated at 30P. A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PL (P < 0.01). AUC analysis revealed an elevated GH and IGF-1 response in the HMB-FA group compared to PL. Conclusion. HMB-FA prior to resistance exercise augments the GH response to high volume resistance exercise compared to PL. These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

No MeSH data available.


Related in: MedlinePlus