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Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the EGAT study.

Sirivarasai J, Kaojarern S, Chanprasertyothin S, Panpunuan P, Petchpoung K, Tatsaneeyapant A, Yoovathaworn K, Sura T, Kaojarern S, Sritara P - Biomed Res Int (2015)

Bottom Line: This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects.Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05).These significant findings are also found in MDA levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

ABSTRACT
Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

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Related in: MedlinePlus

Genetic polymorphism of CAT gene (rs769217) and its activity (upper) and the comparison of blood lead, MDA, and BP of all study populations classified by genotype (lower).
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Related In: Results  -  Collection


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fig3: Genetic polymorphism of CAT gene (rs769217) and its activity (upper) and the comparison of blood lead, MDA, and BP of all study populations classified by genotype (lower).

Mentions: Genotype frequencies of CAT C111T polymorphism in this study population were 32.0% for CC, 46.2% for CT, and 21.7% for TT. The genotype distribution among controls was according to the Hardy-Weinberg equilibrium (P = 0.28). Catalase activity was significantly lower in individuals with TT genotype (27044 U/gHb) compared to those with CT genotype (29103 U/gHb) or CC genotype (30625 U/gHb) (P < 0.01). However, the means of blood lead, MDA, SBP, and DBP of individuals with CC, CT, or TT genotypes did not reveal differences (Figure 3).


Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the EGAT study.

Sirivarasai J, Kaojarern S, Chanprasertyothin S, Panpunuan P, Petchpoung K, Tatsaneeyapant A, Yoovathaworn K, Sura T, Kaojarern S, Sritara P - Biomed Res Int (2015)

Genetic polymorphism of CAT gene (rs769217) and its activity (upper) and the comparison of blood lead, MDA, and BP of all study populations classified by genotype (lower).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352505&req=5

fig3: Genetic polymorphism of CAT gene (rs769217) and its activity (upper) and the comparison of blood lead, MDA, and BP of all study populations classified by genotype (lower).
Mentions: Genotype frequencies of CAT C111T polymorphism in this study population were 32.0% for CC, 46.2% for CT, and 21.7% for TT. The genotype distribution among controls was according to the Hardy-Weinberg equilibrium (P = 0.28). Catalase activity was significantly lower in individuals with TT genotype (27044 U/gHb) compared to those with CT genotype (29103 U/gHb) or CC genotype (30625 U/gHb) (P < 0.01). However, the means of blood lead, MDA, SBP, and DBP of individuals with CC, CT, or TT genotypes did not reveal differences (Figure 3).

Bottom Line: This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects.Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05).These significant findings are also found in MDA levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

ABSTRACT
Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

Show MeSH
Related in: MedlinePlus