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Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the EGAT study.

Sirivarasai J, Kaojarern S, Chanprasertyothin S, Panpunuan P, Petchpoung K, Tatsaneeyapant A, Yoovathaworn K, Sura T, Kaojarern S, Sritara P - Biomed Res Int (2015)

Bottom Line: This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects.Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05).These significant findings are also found in MDA levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

ABSTRACT
Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

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Association between blood lead, serum MDA, and SBP and DBP in the study population.
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fig2: Association between blood lead, serum MDA, and SBP and DBP in the study population.

Mentions: As shown in Table 2, there was a significant increase in blood lead and MDA levels among the three groups, but statistical changes in antioxidant parameters were not found. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). In addition, blood MDA level in hypertensive group (9.64 μmol/L) was statistically higher than those in prehypertensive (8.02 μmol/L) and normotensive groups (8.23 μmol/L, P < 0.01). There were no significant differences in the means of CAT, SOD, GPx, and GSH among the three groups. Our results illustrated that SBP (r = 0.218, P < 0.01), DBP (r = 0.195, P < 0.05), and MDA concentrations (r = 0.147, P < 0.01) were positively correlated with blood lead level (Figure 1). There was no significant association between blood MDA and SBP or DBP (r = 0.131 and P = 0.08 and r = 0.111 and P = 0.10, resp.) (Figure 2).


Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the EGAT study.

Sirivarasai J, Kaojarern S, Chanprasertyothin S, Panpunuan P, Petchpoung K, Tatsaneeyapant A, Yoovathaworn K, Sura T, Kaojarern S, Sritara P - Biomed Res Int (2015)

Association between blood lead, serum MDA, and SBP and DBP in the study population.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352505&req=5

fig2: Association between blood lead, serum MDA, and SBP and DBP in the study population.
Mentions: As shown in Table 2, there was a significant increase in blood lead and MDA levels among the three groups, but statistical changes in antioxidant parameters were not found. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). In addition, blood MDA level in hypertensive group (9.64 μmol/L) was statistically higher than those in prehypertensive (8.02 μmol/L) and normotensive groups (8.23 μmol/L, P < 0.01). There were no significant differences in the means of CAT, SOD, GPx, and GSH among the three groups. Our results illustrated that SBP (r = 0.218, P < 0.01), DBP (r = 0.195, P < 0.05), and MDA concentrations (r = 0.147, P < 0.01) were positively correlated with blood lead level (Figure 1). There was no significant association between blood MDA and SBP or DBP (r = 0.131 and P = 0.08 and r = 0.111 and P = 0.10, resp.) (Figure 2).

Bottom Line: This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects.Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05).These significant findings are also found in MDA levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

ABSTRACT
Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.

Show MeSH
Related in: MedlinePlus