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Transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in B6.Fas mice.

Ruan GP, Yao X, Yang SJ, Wang JX, Shu F, Li ZA, Liu JF, Pang RQ, Pan XH - J Immunol Res (2014)

Bottom Line: No effective treatment for SLE currently exists.After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls.The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.

View Article: PubMed Central - PubMed

Affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.

ABSTRACT

Background: Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists.

Methods: We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice.

Results: After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.

Conclusions: The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.

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Related in: MedlinePlus

(a) Anti-nuclear antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (b) Anti-histone antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (c) Anti-double-stranded DNA antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). *P < 0.01 compared to other groups.
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fig2: (a) Anti-nuclear antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (b) Anti-histone antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (c) Anti-double-stranded DNA antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). *P < 0.01 compared to other groups.

Mentions: The results of anti-nuclear, anti-histone, and anti-double-stranded DNA antibody testing for the five groups are shown in Figure 2. The B6.Fas mouse model group displayed significantly higher levels of anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies than those of the B6.Fas mouse treatment groups.


Transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in B6.Fas mice.

Ruan GP, Yao X, Yang SJ, Wang JX, Shu F, Li ZA, Liu JF, Pang RQ, Pan XH - J Immunol Res (2014)

(a) Anti-nuclear antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (b) Anti-histone antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (c) Anti-double-stranded DNA antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). *P < 0.01 compared to other groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352485&req=5

fig2: (a) Anti-nuclear antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (b) Anti-histone antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). (c) Anti-double-stranded DNA antibody testing in the five groups. The results are expressed as the mean ± standard deviation (n = 10). *P < 0.01 compared to other groups.
Mentions: The results of anti-nuclear, anti-histone, and anti-double-stranded DNA antibody testing for the five groups are shown in Figure 2. The B6.Fas mouse model group displayed significantly higher levels of anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies than those of the B6.Fas mouse treatment groups.

Bottom Line: No effective treatment for SLE currently exists.After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls.The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.

View Article: PubMed Central - PubMed

Affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.

ABSTRACT

Background: Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists.

Methods: We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice.

Results: After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.

Conclusions: The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.

Show MeSH
Related in: MedlinePlus