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The "lipid accumulation product" is associated with 2-hour postload glucose outcomes in overweight/obese subjects with nondiabetic fasting glucose.

Malavazos AE, Cereda E, Ermetici F, Caccialanza R, Briganti S, Rondanelli M, Morricone L - Int J Endocrinol (2015)

Bottom Line: "Lipid accumulation product" (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance.Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions.However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P = 0.006 and P = 0.007, resp.).

View Article: PubMed Central - PubMed

Affiliation: Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.

ABSTRACT
"Lipid accumulation product" (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance. We investigated the accuracy of LAP in identifying oral glucose tolerance test (OGTT) abnormalities and compared it to the homeostasis model assessment of insulin resistance (HOMA-IR) in a population of overweight/obese outpatients presenting with nondiabetic fasting glucose. We studied 381 (male: 23%) adult (age: 18-70 years) overweight/obese Caucasians (body mass index: 36.9 ± 5.4 Kg/m(2)) having fasting plasma glucose < 7.0 mmol/L. OGTT was used to diagnose unknown glucose tolerance abnormalities: impaired glucose tolerance (IGT) and type-2 diabetes mellitus (T2-DM). According to OGTT 92, subjects had an IGT and 33 were diagnosed T2-DM. Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions. However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P = 0.006 and P = 0.007, resp.). LAP seems to be an accurate index, performing better than HOMA-IR, for identifying 2-hour postload OGTT outcomes in overweight/obese patients with nondiabetic fasting glucose.

No MeSH data available.


Related in: MedlinePlus

Prevalence of abnormalities in glucose metabolism by 2-hour postload glucose of an oral glucose tolerance test (Plot (a), IGT; Plot (b), T2-DM; Plot (c), composite glucose tolerance conditions (IGT + T2-DM)) according to tertiles of waist circumference, LAP, and HOMA-IR in the whole study population.
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Related In: Results  -  Collection


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fig1: Prevalence of abnormalities in glucose metabolism by 2-hour postload glucose of an oral glucose tolerance test (Plot (a), IGT; Plot (b), T2-DM; Plot (c), composite glucose tolerance conditions (IGT + T2-DM)) according to tertiles of waist circumference, LAP, and HOMA-IR in the whole study population.

Mentions: According to tertiles of distribution, LAP and HOMA-IR were significantly associated with variables describing glucose metabolism in both genders (Tables 1 and 2), with exception of fasting glucose and LAP in male patients. Conversely, WC was not associated with 2h-PG on a continuous scale. When looking at the frequency of abnormal glucose tolerance conditions, we found that LAP was more strongly associated with 2h-PG outcomes (Figure 1), while WC showed significant limitations. All these findings were particularly evident in age and smoking-adjusted logistic regression analysis (Table 3). A significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions was observed. However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite abnormal glucose tolerance conditions by models including LAP was significantly superior to those including HOMA-IR. Besides, WC was not inferior to HOMA-IR in predicting most glucose metabolism abnormalities with exception of T2-DM.


The "lipid accumulation product" is associated with 2-hour postload glucose outcomes in overweight/obese subjects with nondiabetic fasting glucose.

Malavazos AE, Cereda E, Ermetici F, Caccialanza R, Briganti S, Rondanelli M, Morricone L - Int J Endocrinol (2015)

Prevalence of abnormalities in glucose metabolism by 2-hour postload glucose of an oral glucose tolerance test (Plot (a), IGT; Plot (b), T2-DM; Plot (c), composite glucose tolerance conditions (IGT + T2-DM)) according to tertiles of waist circumference, LAP, and HOMA-IR in the whole study population.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352415&req=5

fig1: Prevalence of abnormalities in glucose metabolism by 2-hour postload glucose of an oral glucose tolerance test (Plot (a), IGT; Plot (b), T2-DM; Plot (c), composite glucose tolerance conditions (IGT + T2-DM)) according to tertiles of waist circumference, LAP, and HOMA-IR in the whole study population.
Mentions: According to tertiles of distribution, LAP and HOMA-IR were significantly associated with variables describing glucose metabolism in both genders (Tables 1 and 2), with exception of fasting glucose and LAP in male patients. Conversely, WC was not associated with 2h-PG on a continuous scale. When looking at the frequency of abnormal glucose tolerance conditions, we found that LAP was more strongly associated with 2h-PG outcomes (Figure 1), while WC showed significant limitations. All these findings were particularly evident in age and smoking-adjusted logistic regression analysis (Table 3). A significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions was observed. However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite abnormal glucose tolerance conditions by models including LAP was significantly superior to those including HOMA-IR. Besides, WC was not inferior to HOMA-IR in predicting most glucose metabolism abnormalities with exception of T2-DM.

Bottom Line: "Lipid accumulation product" (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance.Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions.However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P = 0.006 and P = 0.007, resp.).

View Article: PubMed Central - PubMed

Affiliation: Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.

ABSTRACT
"Lipid accumulation product" (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance. We investigated the accuracy of LAP in identifying oral glucose tolerance test (OGTT) abnormalities and compared it to the homeostasis model assessment of insulin resistance (HOMA-IR) in a population of overweight/obese outpatients presenting with nondiabetic fasting glucose. We studied 381 (male: 23%) adult (age: 18-70 years) overweight/obese Caucasians (body mass index: 36.9 ± 5.4 Kg/m(2)) having fasting plasma glucose < 7.0 mmol/L. OGTT was used to diagnose unknown glucose tolerance abnormalities: impaired glucose tolerance (IGT) and type-2 diabetes mellitus (T2-DM). According to OGTT 92, subjects had an IGT and 33 were diagnosed T2-DM. Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions. However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P = 0.006 and P = 0.007, resp.). LAP seems to be an accurate index, performing better than HOMA-IR, for identifying 2-hour postload OGTT outcomes in overweight/obese patients with nondiabetic fasting glucose.

No MeSH data available.


Related in: MedlinePlus