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Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study.

Hwang W, Lee J, Park J, Joo J - BMC Anesthesiol (2015)

Bottom Line: The VAS score in Remifentanil group was significantly higher than that in Dexmedetomidine group at immediate and late postoperative period (4.1 ± 2.0 vs. 2.3 ± 2.2 at T1, and 4.0 ± 2.2 vs. 2.6 ± 1.7 at T5; P < 0.05).Dexmedetomidine displayed superior efficacy in alleviating pain and in postoperative pain management for 48 hours after PLIF.Clinical Research Information Service (CRiS) Identifier: KCT0001041.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701 South Korea.

ABSTRACT

Background: Total intravenous anesthesia (TIVA) is used widely in spinal surgery because inhalational anesthetics are known to decrease the amplitude of motor evoked potentials. Presently, dexmedetomidine is used as an adjuvant for propofol-based TIVA. We compared the effects of remifentanil and dexmedetomidine on pain intensity as well as the analgesic requirements after post-anesthesia care unit (PACU) discharge in patients undergoing spinal surgery.

Methods: Forty patients scheduled for posterior lumbar interbody fusion (PLIF) surgery under general anesthesia were enrolled. Anesthesia was maintained using propofol at 3-12 mg/kg/h and remifentanil at 0.01-0.2 μg/kg/min in Remifentanil group or dexmedetomidine at 0.01-0.02 μg/kg/min in Dexmedetomidine group, keeping the bispectral index between 40 and 60. Patient-controlled analgesia (PCA) made of hydromophone was applied once the patients opened their eyes in the PACU. The visual analog scale (VAS) score, PCA dosage administered, and postoperative nausea and vomiting (PONV) were recorded at the time of discharge from the PACU (T1) and at 2 (T2), 8 (T3), 24 (T4), and 48 hours (T5) after surgery.

Results: The VAS score in Remifentanil group was significantly higher than that in Dexmedetomidine group at immediate and late postoperative period (4.1 ± 2.0 vs. 2.3 ± 2.2 at T1, and 4.0 ± 2.2 vs. 2.6 ± 1.7 at T5; P < 0.05). Dexmedtomidine group had a statistically significantly lower PCA requirement at every time point after surgery except directly before discharge from the PACU (3.0 ± 1.2 ml vs. 2.3 ± 1.4 ml at T1; P > 0.05, but 69.7 ± 21.4 ml vs. 52.8 ± 10.8 ml at T5; P < 0.05). Patients in Remifentanil group displayed more PONV until 24 hours post-surgery.

Conclusions: Dexmedetomidine displayed superior efficacy in alleviating pain and in postoperative pain management for 48 hours after PLIF. Therefore, dexmedetomidine may be used instead of remifentanil as an adjuvant in propofol-based TIVA.

Trial registration: Clinical Research Information Service (CRiS) Identifier: KCT0001041.

No MeSH data available.


Related in: MedlinePlus

Comparison of postoperative PCA use between the groups. PCA = patient-controlled analgesia; T1 = before PACU discharge; T2 = 2 hours after surgery; T3 = 8 hours after surgery; T4 = 24 hours after surgery; T5 = 48 hours after surgery. *P < 0.05.
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Fig3: Comparison of postoperative PCA use between the groups. PCA = patient-controlled analgesia; T1 = before PACU discharge; T2 = 2 hours after surgery; T3 = 8 hours after surgery; T4 = 24 hours after surgery; T5 = 48 hours after surgery. *P < 0.05.

Mentions: The VAS score in Remifentanil group was significantly higher than in Dexmedetomidine group at every time point after surgery (4.1 ± 2.0 vs. 2.3 ± 2.2 at T1, and 4.0 ± 2.2 vs. 2.6 ± 1.7 at T5; P < 0.05; Figure 2). Dexmedtomidine group had a statistically significantly lower PCA requirement at every time point after surgery except directly before discharge from the PACU (3.0 ± 1.2 ml vs. 2.3 ± 1.4 ml at T1; P > 0.05, and 69.7 ± 21.4 ml vs. 52.8 ± 10.8 ml at T5; P < 0.05; 1 ml = 0.12 mg hydromophone; Figure 3). Finally, the patients in Remifentanil group required more rescue analgesics at every time point after surgery and displayed more PONV until 24 hours post-surgery (P < 0.05; Table 3).Figure 2


Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study.

Hwang W, Lee J, Park J, Joo J - BMC Anesthesiol (2015)

Comparison of postoperative PCA use between the groups. PCA = patient-controlled analgesia; T1 = before PACU discharge; T2 = 2 hours after surgery; T3 = 8 hours after surgery; T4 = 24 hours after surgery; T5 = 48 hours after surgery. *P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4352285&req=5

Fig3: Comparison of postoperative PCA use between the groups. PCA = patient-controlled analgesia; T1 = before PACU discharge; T2 = 2 hours after surgery; T3 = 8 hours after surgery; T4 = 24 hours after surgery; T5 = 48 hours after surgery. *P < 0.05.
Mentions: The VAS score in Remifentanil group was significantly higher than in Dexmedetomidine group at every time point after surgery (4.1 ± 2.0 vs. 2.3 ± 2.2 at T1, and 4.0 ± 2.2 vs. 2.6 ± 1.7 at T5; P < 0.05; Figure 2). Dexmedtomidine group had a statistically significantly lower PCA requirement at every time point after surgery except directly before discharge from the PACU (3.0 ± 1.2 ml vs. 2.3 ± 1.4 ml at T1; P > 0.05, and 69.7 ± 21.4 ml vs. 52.8 ± 10.8 ml at T5; P < 0.05; 1 ml = 0.12 mg hydromophone; Figure 3). Finally, the patients in Remifentanil group required more rescue analgesics at every time point after surgery and displayed more PONV until 24 hours post-surgery (P < 0.05; Table 3).Figure 2

Bottom Line: The VAS score in Remifentanil group was significantly higher than that in Dexmedetomidine group at immediate and late postoperative period (4.1 ± 2.0 vs. 2.3 ± 2.2 at T1, and 4.0 ± 2.2 vs. 2.6 ± 1.7 at T5; P < 0.05).Dexmedetomidine displayed superior efficacy in alleviating pain and in postoperative pain management for 48 hours after PLIF.Clinical Research Information Service (CRiS) Identifier: KCT0001041.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701 South Korea.

ABSTRACT

Background: Total intravenous anesthesia (TIVA) is used widely in spinal surgery because inhalational anesthetics are known to decrease the amplitude of motor evoked potentials. Presently, dexmedetomidine is used as an adjuvant for propofol-based TIVA. We compared the effects of remifentanil and dexmedetomidine on pain intensity as well as the analgesic requirements after post-anesthesia care unit (PACU) discharge in patients undergoing spinal surgery.

Methods: Forty patients scheduled for posterior lumbar interbody fusion (PLIF) surgery under general anesthesia were enrolled. Anesthesia was maintained using propofol at 3-12 mg/kg/h and remifentanil at 0.01-0.2 μg/kg/min in Remifentanil group or dexmedetomidine at 0.01-0.02 μg/kg/min in Dexmedetomidine group, keeping the bispectral index between 40 and 60. Patient-controlled analgesia (PCA) made of hydromophone was applied once the patients opened their eyes in the PACU. The visual analog scale (VAS) score, PCA dosage administered, and postoperative nausea and vomiting (PONV) were recorded at the time of discharge from the PACU (T1) and at 2 (T2), 8 (T3), 24 (T4), and 48 hours (T5) after surgery.

Results: The VAS score in Remifentanil group was significantly higher than that in Dexmedetomidine group at immediate and late postoperative period (4.1 ± 2.0 vs. 2.3 ± 2.2 at T1, and 4.0 ± 2.2 vs. 2.6 ± 1.7 at T5; P < 0.05). Dexmedtomidine group had a statistically significantly lower PCA requirement at every time point after surgery except directly before discharge from the PACU (3.0 ± 1.2 ml vs. 2.3 ± 1.4 ml at T1; P > 0.05, but 69.7 ± 21.4 ml vs. 52.8 ± 10.8 ml at T5; P < 0.05). Patients in Remifentanil group displayed more PONV until 24 hours post-surgery.

Conclusions: Dexmedetomidine displayed superior efficacy in alleviating pain and in postoperative pain management for 48 hours after PLIF. Therefore, dexmedetomidine may be used instead of remifentanil as an adjuvant in propofol-based TIVA.

Trial registration: Clinical Research Information Service (CRiS) Identifier: KCT0001041.

No MeSH data available.


Related in: MedlinePlus