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Intralymphatic immunotherapy.

Senti G, Kündig TM - World Allergy Organ J (2015)

Bottom Line: Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms.Intralymphatic vaccination can maximize immunogenicity and hence efficacy.We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms.

View Article: PubMed Central - PubMed

Affiliation: Clinical Trials Center, University Hospital Zurich, Raemistrasse 100/MOU2, CH-8091 Zurich, Switzerland.

ABSTRACT
Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms. Intralymphatic vaccination can maximize immunogenicity and hence efficacy. We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms. Results of recent prospective and controlled trials suggest that this strategy may be an effective form of allergen immunotherapy.

No MeSH data available.


Intralymphatic injection. A sand blasted needle, being inserted into the lymph node from the right was used for better reflection and therefore visibility in the ultrasound. The dark, hypoechoic area represents the paracortex of the lymph node, which is approx. 15 mm long and 5 mm under the skin surface.
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Fig2: Intralymphatic injection. A sand blasted needle, being inserted into the lymph node from the right was used for better reflection and therefore visibility in the ultrasound. The dark, hypoechoic area represents the paracortex of the lymph node, which is approx. 15 mm long and 5 mm under the skin surface.

Mentions: Subcutaneous lymph nodes are readily located by sonography since their paracortical area is hypoechoic (Figure 2). Injection into a superficial lymph node in the groin is usually performed in a few minutes and does not require great expertise in sonographic technique. What the patient feels during intralymphatic injection is solely the penetration of the skin, as lymph nodes carry few pain receptors. The pain of an intralymphatic injection thus is comparable with that of a subcutaneous injection. In the trials patients have rated intralymphatic injection less painful than venous puncture [64].Figure 2


Intralymphatic immunotherapy.

Senti G, Kündig TM - World Allergy Organ J (2015)

Intralymphatic injection. A sand blasted needle, being inserted into the lymph node from the right was used for better reflection and therefore visibility in the ultrasound. The dark, hypoechoic area represents the paracortex of the lymph node, which is approx. 15 mm long and 5 mm under the skin surface.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4352255&req=5

Fig2: Intralymphatic injection. A sand blasted needle, being inserted into the lymph node from the right was used for better reflection and therefore visibility in the ultrasound. The dark, hypoechoic area represents the paracortex of the lymph node, which is approx. 15 mm long and 5 mm under the skin surface.
Mentions: Subcutaneous lymph nodes are readily located by sonography since their paracortical area is hypoechoic (Figure 2). Injection into a superficial lymph node in the groin is usually performed in a few minutes and does not require great expertise in sonographic technique. What the patient feels during intralymphatic injection is solely the penetration of the skin, as lymph nodes carry few pain receptors. The pain of an intralymphatic injection thus is comparable with that of a subcutaneous injection. In the trials patients have rated intralymphatic injection less painful than venous puncture [64].Figure 2

Bottom Line: Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms.Intralymphatic vaccination can maximize immunogenicity and hence efficacy.We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms.

View Article: PubMed Central - PubMed

Affiliation: Clinical Trials Center, University Hospital Zurich, Raemistrasse 100/MOU2, CH-8091 Zurich, Switzerland.

ABSTRACT
Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms. Intralymphatic vaccination can maximize immunogenicity and hence efficacy. We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms. Results of recent prospective and controlled trials suggest that this strategy may be an effective form of allergen immunotherapy.

No MeSH data available.