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Early response to antibiotic treatment in European patients hospitalized with complicated skin and soft tissue infections: analysis of the REACH study.

Garau J, Blasi F, Medina J, McBride K, Ostermann H, REACH study gro - BMC Infect. Dis. (2015)

Bottom Line: The results obtained with the two definitions for early response were largely similar.This study highlights the significance of early evaluation of patients in hospitals, in potentially preventing prolonged use of inappropriate or ineffective antibacterial therapy.NCT01293435 .

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Hospital Universitari Mutua de Terrassa, Plaza Doctor Robert 5, 08221, Terrassa, Barcelona, Spain. xgarau@gmail.com.

ABSTRACT

Background: The treatment of complicated skin and soft tissue infections (cSSTI) is challenging and many patients do not receive adequate first-line therapy. REACH (REtrospective Study to Assess the Clinical Management of Patients With Moderate-to-Severe cSSTI or Community-Acquired Pneumonia in the Hospital Setting) was a retrospective observational study of cSSTI patients in real-life settings in European hospitals. In this analysis, we review characteristics and outcomes of patients with an early response (≤72 hours) compared with those without an early response to treatment. We also compare the results according to two differing definitions of early response, one of which (Definition 1) requires resolution of fever within 72 hours, in line with previous US FDA guidelines.

Methods: Patients were adults hospitalized with cSSTIs 2010-2011 and requiring treatment with intravenous antibiotics. Clinical management, clinical outcomes and healthcare resource use were assessed using a descriptive analysis approach.

Results: The analysis set included 600 patients, of which 363 showed early response with Definition 1 and 417 with Definition 2. Initial treatment modification was frequent, and highest in patients without early response (48.1% with Definition 1). Patients without early response were more likely to have diabetes than those with early response (31.6% vs. 22.9%, respectively) and to suffer from more severe disease (e.g. skin necrosis: 14.8% and 7.7%, respectively), to be infected with difficult-to-treat microorganisms and to have recurrent infections. Furthermore, patients without early response had a higher rate of adverse clinical outcomes (e.g. septic shock) and higher use of healthcare resources. The results obtained with the two definitions for early response were largely similar.

Conclusions: This study highlights the significance of early evaluation of patients in hospitals, in potentially preventing prolonged use of inappropriate or ineffective antibacterial therapy.

Trial registration: NCT01293435 .

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Related in: MedlinePlus

Patient classification with Definition 1 and Definition 2. Green denotes patients with an early response to treatment (≤72 hours), red denotes patients without an early response and yellow is used for unknowns. Mixed colours indicate those patients who had a different classification with the two definitions.
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Fig1: Patient classification with Definition 1 and Definition 2. Green denotes patients with an early response to treatment (≤72 hours), red denotes patients without an early response and yellow is used for unknowns. Mixed colours indicate those patients who had a different classification with the two definitions.

Mentions: Of 1,995 patients enrolled in the REACH study, 1,513 (76%) had information detailing response to treatment recorded (Additional file 1: Table S2). The analysis set included 600 patients who had available data for assessment by D1 (Figure 1). A total of 363 (60.5%) of these patients were classified as early responders, while 237 (39.5%) were not. When D2 was used, an additional 54 (9%) patients were classified as early responders. This change in response outcome under the alternative definition was due to the fever resolution criterion in Q1 (47 patients) and to symptom resolution in Q5 (7 patients). Regardless of the consideration of fever resolution, 553/600 patients (92.2%) were included in the same classification. Therefore, including fever resolution restricted the number of patients who met the definition for early response, but the outcomes were largely unaffected.Figure 1


Early response to antibiotic treatment in European patients hospitalized with complicated skin and soft tissue infections: analysis of the REACH study.

Garau J, Blasi F, Medina J, McBride K, Ostermann H, REACH study gro - BMC Infect. Dis. (2015)

Patient classification with Definition 1 and Definition 2. Green denotes patients with an early response to treatment (≤72 hours), red denotes patients without an early response and yellow is used for unknowns. Mixed colours indicate those patients who had a different classification with the two definitions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4352248&req=5

Fig1: Patient classification with Definition 1 and Definition 2. Green denotes patients with an early response to treatment (≤72 hours), red denotes patients without an early response and yellow is used for unknowns. Mixed colours indicate those patients who had a different classification with the two definitions.
Mentions: Of 1,995 patients enrolled in the REACH study, 1,513 (76%) had information detailing response to treatment recorded (Additional file 1: Table S2). The analysis set included 600 patients who had available data for assessment by D1 (Figure 1). A total of 363 (60.5%) of these patients were classified as early responders, while 237 (39.5%) were not. When D2 was used, an additional 54 (9%) patients were classified as early responders. This change in response outcome under the alternative definition was due to the fever resolution criterion in Q1 (47 patients) and to symptom resolution in Q5 (7 patients). Regardless of the consideration of fever resolution, 553/600 patients (92.2%) were included in the same classification. Therefore, including fever resolution restricted the number of patients who met the definition for early response, but the outcomes were largely unaffected.Figure 1

Bottom Line: The results obtained with the two definitions for early response were largely similar.This study highlights the significance of early evaluation of patients in hospitals, in potentially preventing prolonged use of inappropriate or ineffective antibacterial therapy.NCT01293435 .

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Hospital Universitari Mutua de Terrassa, Plaza Doctor Robert 5, 08221, Terrassa, Barcelona, Spain. xgarau@gmail.com.

ABSTRACT

Background: The treatment of complicated skin and soft tissue infections (cSSTI) is challenging and many patients do not receive adequate first-line therapy. REACH (REtrospective Study to Assess the Clinical Management of Patients With Moderate-to-Severe cSSTI or Community-Acquired Pneumonia in the Hospital Setting) was a retrospective observational study of cSSTI patients in real-life settings in European hospitals. In this analysis, we review characteristics and outcomes of patients with an early response (≤72 hours) compared with those without an early response to treatment. We also compare the results according to two differing definitions of early response, one of which (Definition 1) requires resolution of fever within 72 hours, in line with previous US FDA guidelines.

Methods: Patients were adults hospitalized with cSSTIs 2010-2011 and requiring treatment with intravenous antibiotics. Clinical management, clinical outcomes and healthcare resource use were assessed using a descriptive analysis approach.

Results: The analysis set included 600 patients, of which 363 showed early response with Definition 1 and 417 with Definition 2. Initial treatment modification was frequent, and highest in patients without early response (48.1% with Definition 1). Patients without early response were more likely to have diabetes than those with early response (31.6% vs. 22.9%, respectively) and to suffer from more severe disease (e.g. skin necrosis: 14.8% and 7.7%, respectively), to be infected with difficult-to-treat microorganisms and to have recurrent infections. Furthermore, patients without early response had a higher rate of adverse clinical outcomes (e.g. septic shock) and higher use of healthcare resources. The results obtained with the two definitions for early response were largely similar.

Conclusions: This study highlights the significance of early evaluation of patients in hospitals, in potentially preventing prolonged use of inappropriate or ineffective antibacterial therapy.

Trial registration: NCT01293435 .

Show MeSH
Related in: MedlinePlus