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The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis.

Zhang SK, Guo LW, Chen Q, Zhang M, Liu SZ, Quan PL, Lu JB, Sun XB - BMC Cancer (2015)

Bottom Line: A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).Results in this study may have important implications for esophageal cancer prevention and treatment in China.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology, Henan Cancer Hospital, Henan Office for Cancer Control and Research, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, shaokaizhang@126.com.

ABSTRACT

Background: The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.

Methods: Studies on HPV infection and esophageal cancer were identified. A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.

Results: A total of 1442 esophageal cancer cases and 1602 controls from 10 included studies were evaluated to estimate the association between HPV 16 infection and esophageal cancer risk. The ORs for each case-control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07). In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).

Conclusions: This study indicates that HPV-16 infection may be a risk factor for esophageal cancer among Chinese population, supporting an etiological role of HPV16 in this malignancy. Results in this study may have important implications for esophageal cancer prevention and treatment in China.

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Forest plot for meta-analysis of the association of HPV with esophageal cancer in 10 case–control studies.
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Fig2: Forest plot for meta-analysis of the association of HPV with esophageal cancer in 10 case–control studies.

Mentions: Based on the heterogeneity test, there was a moderate heterogeneity between included studies (Q test Pheterogeneity < 0.001, I2 = 55.1%). Therefore, the random-effects model was chosen to evaluate the pooled ORs. Individual and pooled OR estimates derived from a random effect model analysis were illustrated in the Forest plot. As shown in Figure 2, the ORs for each case–control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07), indicating a significant association between HPV 16 infection and esophageal cancer.Figure 2


The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis.

Zhang SK, Guo LW, Chen Q, Zhang M, Liu SZ, Quan PL, Lu JB, Sun XB - BMC Cancer (2015)

Forest plot for meta-analysis of the association of HPV with esophageal cancer in 10 case–control studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4352244&req=5

Fig2: Forest plot for meta-analysis of the association of HPV with esophageal cancer in 10 case–control studies.
Mentions: Based on the heterogeneity test, there was a moderate heterogeneity between included studies (Q test Pheterogeneity < 0.001, I2 = 55.1%). Therefore, the random-effects model was chosen to evaluate the pooled ORs. Individual and pooled OR estimates derived from a random effect model analysis were illustrated in the Forest plot. As shown in Figure 2, the ORs for each case–control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07), indicating a significant association between HPV 16 infection and esophageal cancer.Figure 2

Bottom Line: A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).Results in this study may have important implications for esophageal cancer prevention and treatment in China.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology, Henan Cancer Hospital, Henan Office for Cancer Control and Research, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, shaokaizhang@126.com.

ABSTRACT

Background: The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.

Methods: Studies on HPV infection and esophageal cancer were identified. A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.

Results: A total of 1442 esophageal cancer cases and 1602 controls from 10 included studies were evaluated to estimate the association between HPV 16 infection and esophageal cancer risk. The ORs for each case-control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07). In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).

Conclusions: This study indicates that HPV-16 infection may be a risk factor for esophageal cancer among Chinese population, supporting an etiological role of HPV16 in this malignancy. Results in this study may have important implications for esophageal cancer prevention and treatment in China.

Show MeSH
Related in: MedlinePlus