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The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis.

Zhang SK, Guo LW, Chen Q, Zhang M, Liu SZ, Quan PL, Lu JB, Sun XB - BMC Cancer (2015)

Bottom Line: A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).Results in this study may have important implications for esophageal cancer prevention and treatment in China.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology, Henan Cancer Hospital, Henan Office for Cancer Control and Research, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, shaokaizhang@126.com.

ABSTRACT

Background: The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.

Methods: Studies on HPV infection and esophageal cancer were identified. A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.

Results: A total of 1442 esophageal cancer cases and 1602 controls from 10 included studies were evaluated to estimate the association between HPV 16 infection and esophageal cancer risk. The ORs for each case-control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07). In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).

Conclusions: This study indicates that HPV-16 infection may be a risk factor for esophageal cancer among Chinese population, supporting an etiological role of HPV16 in this malignancy. Results in this study may have important implications for esophageal cancer prevention and treatment in China.

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Related in: MedlinePlus

Flow diagram for the selection of included studies.
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Related In: Results  -  Collection

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Fig1: Flow diagram for the selection of included studies.

Mentions: FigureĀ 1 shows the flow diagram for the selection of included studies. The systematic literatures search yielded 417 articles relevant to the topic using different combination of key words, of which 156 were considered as having potential value and the full texts were retrieved for detailed evaluation. One hundred and twenty-two of the 156 articles were subsequently excluded from the meta-analysis. The majority of the reasons for exclusion were: studies not conducted in Chinese population, studies not related to HPV 16 or studies not tested by PCR-based assay. Duplicated studies and reviews without detailed information were also excluded. Furthermore, twenty-four studies were also excluded as they were not case control or cohort studies. At last, we included 10 eligible studies in the meta-analysis [17-26].Figure 1


The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis.

Zhang SK, Guo LW, Chen Q, Zhang M, Liu SZ, Quan PL, Lu JB, Sun XB - BMC Cancer (2015)

Flow diagram for the selection of included studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4352244&req=5

Fig1: Flow diagram for the selection of included studies.
Mentions: FigureĀ 1 shows the flow diagram for the selection of included studies. The systematic literatures search yielded 417 articles relevant to the topic using different combination of key words, of which 156 were considered as having potential value and the full texts were retrieved for detailed evaluation. One hundred and twenty-two of the 156 articles were subsequently excluded from the meta-analysis. The majority of the reasons for exclusion were: studies not conducted in Chinese population, studies not related to HPV 16 or studies not tested by PCR-based assay. Duplicated studies and reviews without detailed information were also excluded. Furthermore, twenty-four studies were also excluded as they were not case control or cohort studies. At last, we included 10 eligible studies in the meta-analysis [17-26].Figure 1

Bottom Line: A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).Results in this study may have important implications for esophageal cancer prevention and treatment in China.

View Article: PubMed Central - PubMed

Affiliation: Department of Cancer Epidemiology, Henan Cancer Hospital, Henan Office for Cancer Control and Research, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, shaokaizhang@126.com.

ABSTRACT

Background: The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.

Methods: Studies on HPV infection and esophageal cancer were identified. A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.

Results: A total of 1442 esophageal cancer cases and 1602 controls from 10 included studies were evaluated to estimate the association between HPV 16 infection and esophageal cancer risk. The ORs for each case-control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07). In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).

Conclusions: This study indicates that HPV-16 infection may be a risk factor for esophageal cancer among Chinese population, supporting an etiological role of HPV16 in this malignancy. Results in this study may have important implications for esophageal cancer prevention and treatment in China.

Show MeSH
Related in: MedlinePlus