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The selective impairment of resting-state functional connectivity of the lateral subregion of the frontal pole in schizophrenia.

Zhou Y, Ma X, Wang D, Qin W, Zhu J, Zhuo C, Yu C - PLoS ONE (2015)

Bottom Line: Direct comparison between groups revealed reduced rsFCs between the bilateral FPl and several cognitive-related regions, including the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex/precuneus, temporal cortex and inferior parietal lobule in schizophrenia.Although the FPl exhibited obvious atrophy, rsFC changes were unrelated to volumetric atrophy in the FPl, to duration of illness, and to antipsychotic medication dosage.No significant differences were observed in the rsFCs of other FP subregions.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.

ABSTRACT

Objective: Although extensive resting-state functional connectivity (rsFC) changes have been reported in schizophrenia, rsFC changes of the frontal pole (FP) remain unclear. The FP contains several subregions with different connection patterns; however, it is unknown whether the FP subregions are differentially affected in schizophrenia. To explore this possibility, we compared rsFC differences of the FP subregions between schizophrenia patients and healthy controls.

Method: One hundred healthy controls and 91 patients with schizophrenia underwent resting-state functional MRI with a sensitivity-encoded spiral-in (SENSE-SPIRAL) imaging sequence to reduced susceptibility-induced signal loss and distortion. The FP was subdivided into the orbital (FPo), medial (FPm), and lateral (FPl) subregions. Mean fMRI time series were extracted for each FP subregion and entered into a seed-based rsFC analysis.

Results: The FP subregions exhibited differential rsFC patterns in both healthy controls and schizophrenia patients. Direct comparison between groups revealed reduced rsFCs between the bilateral FPl and several cognitive-related regions, including the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex/precuneus, temporal cortex and inferior parietal lobule in schizophrenia. Although the FPl exhibited obvious atrophy, rsFC changes were unrelated to volumetric atrophy in the FPl, to duration of illness, and to antipsychotic medication dosage. No significant differences were observed in the rsFCs of other FP subregions.

Conclusion: These findings suggest a selective (the lateral subregion) functional disconnection of the FP subregions in schizophrenia.

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Related in: MedlinePlus

Altered rsFC of the bilateral lateral subregions of the frontal pole in schizophrenia patients.Brain regions exhibit significantly reduced rsFC with the left FPl (A, C) and the right FPl (B, D) in schizophrenia patients. (A, B) show results derived from the method of the maximal probability map and (C, D) demonstrate results derived from the method that using spherical regions of interest as seed regions. Of note, the between-group differences in the rsFC of the bilateral lateral subregions of the FP exhibited highly similar patterns between with (E and F) and without (A, B) correcting GM volume. The statistical threshold was set at p<0.05, FDR correction, two-tailed and cluster size>30 voxels. FPl, lateral subregion of the frontal pole; FP, frontal pole; L, left, R, right.
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pone.0119176.g003: Altered rsFC of the bilateral lateral subregions of the frontal pole in schizophrenia patients.Brain regions exhibit significantly reduced rsFC with the left FPl (A, C) and the right FPl (B, D) in schizophrenia patients. (A, B) show results derived from the method of the maximal probability map and (C, D) demonstrate results derived from the method that using spherical regions of interest as seed regions. Of note, the between-group differences in the rsFC of the bilateral lateral subregions of the FP exhibited highly similar patterns between with (E and F) and without (A, B) correcting GM volume. The statistical threshold was set at p<0.05, FDR correction, two-tailed and cluster size>30 voxels. FPl, lateral subregion of the frontal pole; FP, frontal pole; L, left, R, right.

Mentions: Group differences in rsFCs of the FP subregions are summarized in Table 2, Fig. 3A and B. Compared with healthy controls, schizophrenia patients exhibited reduced rsFCs between the left FPl and brain regions that are involved in cognitive processing, including the left DLPFC, ACC, MPFC, TC, PCC/Pcu, and IPL. The patients also had reduced rsFCs between the right FPl and the right superior frontal gyrus (SFG) (p<0.05, two-tailed, FDR correction, cluster size >30 voxels). To further determine the disconnection pattern of the right FPl, we used an uncorrected threshold of p<0.05 and found that the disconnection pattern of the right FPl was similar to that of the left FPl (S1 Fig). No group differences were observed in the bilateral FPo and the bilateral FPm.


The selective impairment of resting-state functional connectivity of the lateral subregion of the frontal pole in schizophrenia.

Zhou Y, Ma X, Wang D, Qin W, Zhu J, Zhuo C, Yu C - PLoS ONE (2015)

Altered rsFC of the bilateral lateral subregions of the frontal pole in schizophrenia patients.Brain regions exhibit significantly reduced rsFC with the left FPl (A, C) and the right FPl (B, D) in schizophrenia patients. (A, B) show results derived from the method of the maximal probability map and (C, D) demonstrate results derived from the method that using spherical regions of interest as seed regions. Of note, the between-group differences in the rsFC of the bilateral lateral subregions of the FP exhibited highly similar patterns between with (E and F) and without (A, B) correcting GM volume. The statistical threshold was set at p<0.05, FDR correction, two-tailed and cluster size>30 voxels. FPl, lateral subregion of the frontal pole; FP, frontal pole; L, left, R, right.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4352081&req=5

pone.0119176.g003: Altered rsFC of the bilateral lateral subregions of the frontal pole in schizophrenia patients.Brain regions exhibit significantly reduced rsFC with the left FPl (A, C) and the right FPl (B, D) in schizophrenia patients. (A, B) show results derived from the method of the maximal probability map and (C, D) demonstrate results derived from the method that using spherical regions of interest as seed regions. Of note, the between-group differences in the rsFC of the bilateral lateral subregions of the FP exhibited highly similar patterns between with (E and F) and without (A, B) correcting GM volume. The statistical threshold was set at p<0.05, FDR correction, two-tailed and cluster size>30 voxels. FPl, lateral subregion of the frontal pole; FP, frontal pole; L, left, R, right.
Mentions: Group differences in rsFCs of the FP subregions are summarized in Table 2, Fig. 3A and B. Compared with healthy controls, schizophrenia patients exhibited reduced rsFCs between the left FPl and brain regions that are involved in cognitive processing, including the left DLPFC, ACC, MPFC, TC, PCC/Pcu, and IPL. The patients also had reduced rsFCs between the right FPl and the right superior frontal gyrus (SFG) (p<0.05, two-tailed, FDR correction, cluster size >30 voxels). To further determine the disconnection pattern of the right FPl, we used an uncorrected threshold of p<0.05 and found that the disconnection pattern of the right FPl was similar to that of the left FPl (S1 Fig). No group differences were observed in the bilateral FPo and the bilateral FPm.

Bottom Line: Direct comparison between groups revealed reduced rsFCs between the bilateral FPl and several cognitive-related regions, including the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex/precuneus, temporal cortex and inferior parietal lobule in schizophrenia.Although the FPl exhibited obvious atrophy, rsFC changes were unrelated to volumetric atrophy in the FPl, to duration of illness, and to antipsychotic medication dosage.No significant differences were observed in the rsFCs of other FP subregions.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.

ABSTRACT

Objective: Although extensive resting-state functional connectivity (rsFC) changes have been reported in schizophrenia, rsFC changes of the frontal pole (FP) remain unclear. The FP contains several subregions with different connection patterns; however, it is unknown whether the FP subregions are differentially affected in schizophrenia. To explore this possibility, we compared rsFC differences of the FP subregions between schizophrenia patients and healthy controls.

Method: One hundred healthy controls and 91 patients with schizophrenia underwent resting-state functional MRI with a sensitivity-encoded spiral-in (SENSE-SPIRAL) imaging sequence to reduced susceptibility-induced signal loss and distortion. The FP was subdivided into the orbital (FPo), medial (FPm), and lateral (FPl) subregions. Mean fMRI time series were extracted for each FP subregion and entered into a seed-based rsFC analysis.

Results: The FP subregions exhibited differential rsFC patterns in both healthy controls and schizophrenia patients. Direct comparison between groups revealed reduced rsFCs between the bilateral FPl and several cognitive-related regions, including the dorsolateral prefrontal cortex, medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex/precuneus, temporal cortex and inferior parietal lobule in schizophrenia. Although the FPl exhibited obvious atrophy, rsFC changes were unrelated to volumetric atrophy in the FPl, to duration of illness, and to antipsychotic medication dosage. No significant differences were observed in the rsFCs of other FP subregions.

Conclusion: These findings suggest a selective (the lateral subregion) functional disconnection of the FP subregions in schizophrenia.

Show MeSH
Related in: MedlinePlus