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One-pot, three-component arylalkynyl sulfone synthesis.

Chen CC, Waser J - Org. Lett. (2015)

Bottom Line: A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported.A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.

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Affiliation: Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.

ABSTRACT
A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.

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Recent Reports on Sulfone Synthesis
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sch1: Recent Reports on Sulfone Synthesis


One-pot, three-component arylalkynyl sulfone synthesis.

Chen CC, Waser J - Org. Lett. (2015)

Recent Reports on Sulfone Synthesis
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4342956&req=5

sch1: Recent Reports on Sulfone Synthesis
Bottom Line: A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported.A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.

ABSTRACT
A one-pot three-component protocol for the preparation of arylsulfonyl alkynes through the reaction of ethynyl-benziodoxolone (EBX) reagents, DABSO (DABCO·SO2), and either organomagnesium reagents or aryl iodides with a palladium catalyst is reported. A broad range of aryl and heteroarylalkynyl sulfones were obtained in 46-85% overall yield.

Show MeSH