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Brown adipose tissue harbors a distinct sub-population of regulatory T cells.

Medrikova D, Sijmonsma TP, Sowodniok K, Richards DM, Delacher M, Sticht C, Gretz N, Schafmeier T, Feuerer M, Herzig S - PLoS ONE (2015)

Bottom Line: Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control.Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature.As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

View Article: PubMed Central - PubMed

Affiliation: Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany.

ABSTRACT
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

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Physiological parameters.(A) Body weight (BW) and (B) adipose tissues weights of Treg cell-proficient (PBS) and Treg cell-deficient (DT) mice after cold exposure. BAT, brown adipose tissue; scWAT, subcutaneous white adipose tissue, aWAT, abdominal white adipose tissue. (C) Blood glucose, (D) serum non-estherified fatty acids (NEFA) and (E) serum triglycerides in PBS and DT mice. Values are mean ± SD (n = 9–10); *P<0.05 (Student’s t-test).
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pone.0118534.g003: Physiological parameters.(A) Body weight (BW) and (B) adipose tissues weights of Treg cell-proficient (PBS) and Treg cell-deficient (DT) mice after cold exposure. BAT, brown adipose tissue; scWAT, subcutaneous white adipose tissue, aWAT, abdominal white adipose tissue. (C) Blood glucose, (D) serum non-estherified fatty acids (NEFA) and (E) serum triglycerides in PBS and DT mice. Values are mean ± SD (n = 9–10); *P<0.05 (Student’s t-test).

Mentions: Of note, diphtheria toxin administration had no effect on oxygen consumption in wild-type animals (data not shonw), demonstrating the specificity of the observed effects. Also, body and adipose tissue weights and other metabolic parameters, including blood glucose, serum non-esterified fatty acids (NEFA) and triglycerides, remained unaffected by Treg cell-depletion (Fig. 3A-E).


Brown adipose tissue harbors a distinct sub-population of regulatory T cells.

Medrikova D, Sijmonsma TP, Sowodniok K, Richards DM, Delacher M, Sticht C, Gretz N, Schafmeier T, Feuerer M, Herzig S - PLoS ONE (2015)

Physiological parameters.(A) Body weight (BW) and (B) adipose tissues weights of Treg cell-proficient (PBS) and Treg cell-deficient (DT) mice after cold exposure. BAT, brown adipose tissue; scWAT, subcutaneous white adipose tissue, aWAT, abdominal white adipose tissue. (C) Blood glucose, (D) serum non-estherified fatty acids (NEFA) and (E) serum triglycerides in PBS and DT mice. Values are mean ± SD (n = 9–10); *P<0.05 (Student’s t-test).
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4340926&req=5

pone.0118534.g003: Physiological parameters.(A) Body weight (BW) and (B) adipose tissues weights of Treg cell-proficient (PBS) and Treg cell-deficient (DT) mice after cold exposure. BAT, brown adipose tissue; scWAT, subcutaneous white adipose tissue, aWAT, abdominal white adipose tissue. (C) Blood glucose, (D) serum non-estherified fatty acids (NEFA) and (E) serum triglycerides in PBS and DT mice. Values are mean ± SD (n = 9–10); *P<0.05 (Student’s t-test).
Mentions: Of note, diphtheria toxin administration had no effect on oxygen consumption in wild-type animals (data not shonw), demonstrating the specificity of the observed effects. Also, body and adipose tissue weights and other metabolic parameters, including blood glucose, serum non-esterified fatty acids (NEFA) and triglycerides, remained unaffected by Treg cell-depletion (Fig. 3A-E).

Bottom Line: Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control.Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature.As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

View Article: PubMed Central - PubMed

Affiliation: Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, Heidelberg University, 69120, Heidelberg, Germany.

ABSTRACT
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

Show MeSH
Related in: MedlinePlus