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Correlation between blood pressure changes and AMS, sleeping quality and exercise upon high-altitude exposure in young Chinese men.

Liu Y, Zhang JH, Gao XB, Wu XJ, Yu J, Chen JF, Bian SZ, Ding XH, Huang L - Mil Med Res (2014)

Bottom Line: Lake Louise criteria were used to diagnose AMS.After acute exposure to 3,700 m, diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) rose gradually and continually (P < 0.05).Analysis showed a relationship with AMS for only MABP (P < 0.05) but not for SBP and DBP (P > 0.05).

View Article: PubMed Central - PubMed

Affiliation: Institute of Cardiovascular Diseases of PLA; Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 China.

ABSTRACT

Background: Excessive elevation of arterial blood pressure (BP) at high altitude can be detrimental to our health due to acute mountain sickness (AMS) or some AMS symptoms. This prospective and observational study aimed to elucidate blood pressure changes induced by exposure to high-altitude hypoxia and the relationships of these changes with AMS prevalence, AMS severity, sleep quality and exercise condition in healthy young men.

Methods: A prospective observational study was performed in 931 male young adults exposed to high altitude at 3,700 m (Lhasa) from low altitude (LA, 500 m). Blood pressure measurement and AMS symptom questionnaires were performed at LA and on day 1, 3, 5, and 7 of exposure to high altitude. Lake Louise criteria were used to diagnose AMS. Likewise, the Athens Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS) were filled out at LA and on day 1, 3, and 7 of exposure to high altitude.

Results: After acute exposure to 3,700 m, diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) rose gradually and continually (P < 0.05). Analysis showed a relationship with AMS for only MABP (P < 0.05) but not for SBP and DBP (P > 0.05). Poor sleeping quality was generally associated with higher SBP or DBP at high altitude, although inconsistent results were obtained at different time (P < 0.05). SBP and Pulse BP increased noticeably after high-altitude exercise (P < 0.05).

Conclusions: Our data demonstrate notable blood pressure changes under exposure to different high-altitude conditions: 1) BP increased over time. 2) Higher BP generally accompanied poor sleeping quality and higher incidence of AMS. 3) SBP and Pulse BP were higher after high-altitude exercise. Therefore, we should put more effort into monitoring BP after exposure to high altitude in order to guard against excessive increases in BP.

No MeSH data available.


Related in: MedlinePlus

Data collection schedule. This research utilized an all-around design on selected young Chinese men for the test condition. The test conditions were defined as LA (500 m, Control group) for baseline testing and abrupt exposure to 3,700 m after approximately a week at LA.
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Fig1: Data collection schedule. This research utilized an all-around design on selected young Chinese men for the test condition. The test conditions were defined as LA (500 m, Control group) for baseline testing and abrupt exposure to 3,700 m after approximately a week at LA.

Mentions: This study was performed at two locations that were separately defined as low altitude (Chongzhou, LA, 500 m) and high altitude (Lhasa, 3,700 m). Low-altitude subjects ascended to 3,700 m after approximately a week on the Chongzhou plain. Participants completed the Lake Louise Score (LLS) AMS self-assessment test, the Athens Insomnia Scale (AIS) questionnaire and the Epworth Sleepiness Scale (ESS) questionnaire. Arterial blood pressure measurements were carried out. All of the trial procedures were performed at 500 m within one week before ascending in Chongzhou and within 24 h after arrival at 3,700 m (in Lhasa, approximately 13:00 pm from June 21st to 25th, 2012, and examinations were performed at approximately 8:00–11:00 am on the next morning upon arrival. The minimal and maximal times from arrival to the examination were 19 hours and 22 hours, respectively). The subjects stayed at 3,700 m for a week before leaving for the next work place. An outline of the study design and testing schedule is shown in Figure 1.Figure 1


Correlation between blood pressure changes and AMS, sleeping quality and exercise upon high-altitude exposure in young Chinese men.

Liu Y, Zhang JH, Gao XB, Wu XJ, Yu J, Chen JF, Bian SZ, Ding XH, Huang L - Mil Med Res (2014)

Data collection schedule. This research utilized an all-around design on selected young Chinese men for the test condition. The test conditions were defined as LA (500 m, Control group) for baseline testing and abrupt exposure to 3,700 m after approximately a week at LA.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4340834&req=5

Fig1: Data collection schedule. This research utilized an all-around design on selected young Chinese men for the test condition. The test conditions were defined as LA (500 m, Control group) for baseline testing and abrupt exposure to 3,700 m after approximately a week at LA.
Mentions: This study was performed at two locations that were separately defined as low altitude (Chongzhou, LA, 500 m) and high altitude (Lhasa, 3,700 m). Low-altitude subjects ascended to 3,700 m after approximately a week on the Chongzhou plain. Participants completed the Lake Louise Score (LLS) AMS self-assessment test, the Athens Insomnia Scale (AIS) questionnaire and the Epworth Sleepiness Scale (ESS) questionnaire. Arterial blood pressure measurements were carried out. All of the trial procedures were performed at 500 m within one week before ascending in Chongzhou and within 24 h after arrival at 3,700 m (in Lhasa, approximately 13:00 pm from June 21st to 25th, 2012, and examinations were performed at approximately 8:00–11:00 am on the next morning upon arrival. The minimal and maximal times from arrival to the examination were 19 hours and 22 hours, respectively). The subjects stayed at 3,700 m for a week before leaving for the next work place. An outline of the study design and testing schedule is shown in Figure 1.Figure 1

Bottom Line: Lake Louise criteria were used to diagnose AMS.After acute exposure to 3,700 m, diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) rose gradually and continually (P < 0.05).Analysis showed a relationship with AMS for only MABP (P < 0.05) but not for SBP and DBP (P > 0.05).

View Article: PubMed Central - PubMed

Affiliation: Institute of Cardiovascular Diseases of PLA; Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037 China.

ABSTRACT

Background: Excessive elevation of arterial blood pressure (BP) at high altitude can be detrimental to our health due to acute mountain sickness (AMS) or some AMS symptoms. This prospective and observational study aimed to elucidate blood pressure changes induced by exposure to high-altitude hypoxia and the relationships of these changes with AMS prevalence, AMS severity, sleep quality and exercise condition in healthy young men.

Methods: A prospective observational study was performed in 931 male young adults exposed to high altitude at 3,700 m (Lhasa) from low altitude (LA, 500 m). Blood pressure measurement and AMS symptom questionnaires were performed at LA and on day 1, 3, 5, and 7 of exposure to high altitude. Lake Louise criteria were used to diagnose AMS. Likewise, the Athens Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS) were filled out at LA and on day 1, 3, and 7 of exposure to high altitude.

Results: After acute exposure to 3,700 m, diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) rose gradually and continually (P < 0.05). Analysis showed a relationship with AMS for only MABP (P < 0.05) but not for SBP and DBP (P > 0.05). Poor sleeping quality was generally associated with higher SBP or DBP at high altitude, although inconsistent results were obtained at different time (P < 0.05). SBP and Pulse BP increased noticeably after high-altitude exercise (P < 0.05).

Conclusions: Our data demonstrate notable blood pressure changes under exposure to different high-altitude conditions: 1) BP increased over time. 2) Higher BP generally accompanied poor sleeping quality and higher incidence of AMS. 3) SBP and Pulse BP were higher after high-altitude exercise. Therefore, we should put more effort into monitoring BP after exposure to high altitude in order to guard against excessive increases in BP.

No MeSH data available.


Related in: MedlinePlus