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Stem cells, colorectal cancer and cancer stem cell markers correlations.

Cherciu I, Bărbălan A, Pirici D, Mărgăritescu C, Săftoiu A - Curr Health Sci J (2014)

Bottom Line: These alterations will cause the changeover to cancerous stem cells (CSC) having two main characteristics: tumor initiation and maintenance.Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings.Isolation of CR-CSCs can be achieved by targeting and selecting subpopulation of tumor cells based on expression of one or multiple cell surface markers associated with cancer self-renewal, markers as: CD133, CD166, CD44, CD24, beta1 integrin-CD29, Lgr5, EpCAM (ESA), ALDH-1, Msi-1, DCAMLK1 or EphB receptors.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.

ABSTRACT
: The idea of stem cells as being progenitors of cancer was initially controversial, but later supported by research in the field of leukemia and solid tumors. Afterwards, it was established that genetic abnormalities can affect the stem and progenitor cells, leading to uncontrolled replication and deregulated differentiation. These alterations will cause the changeover to cancerous stem cells (CSC) having two main characteristics: tumor initiation and maintenance. This review will focus on the colorectal cancer stem cell (CR-CSCs) theory which provides a better understanding of different tumor processes: initiation, aggressive growth, recurrence, treatment resistance and metastasis. A search in PubMed/Medline was performed using the following keywords: colorectal cancer stem cells (CR-CSCs), colorectal neoplasms stem cells, colorectal cancer stem cell (CR-CSCs) markers, etc. Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings. Isolation of CR-CSCs can be achieved by targeting and selecting subpopulation of tumor cells based on expression of one or multiple cell surface markers associated with cancer self-renewal, markers as: CD133, CD166, CD44, CD24, beta1 integrin-CD29, Lgr5, EpCAM (ESA), ALDH-1, Msi-1, DCAMLK1 or EphB receptors. The identification and localization of CR-CSCs through different markers will hopefully lead to a better stratification of prognosis and treatment response, as well as the development of new effective strategies for cancer management.

No MeSH data available.


Related in: MedlinePlus

Colorectal Cancer Carcinogenesis Models (modified after [10])
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Related In: Results  -  Collection

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Figure 1: Colorectal Cancer Carcinogenesis Models (modified after [10])

Mentions: A recent study endorsed the idea that CRC pathogenesis might be induced by transformed CSCs that have the ability to self-renew and to aberrantly differentiate, associating also the interaction between the microenvironment and CR-CSCs [7]. Tumor micro-environment plays an important role in the progression of CRC through the following steps of invasion and metastatic dissemination [8]. Metastasis are a consequence of uncontrolled proliferation of cancer cells group which includes the subpopulation of CR-CSCs [9]. This proliferation process represents the effect of a disequilibrium between the positive and negative angiogenic factors (released by both tumor and host cells), disequilibrium generated by the cancer-stromal cell interaction (Fig.1) [10].


Stem cells, colorectal cancer and cancer stem cell markers correlations.

Cherciu I, Bărbălan A, Pirici D, Mărgăritescu C, Săftoiu A - Curr Health Sci J (2014)

Colorectal Cancer Carcinogenesis Models (modified after [10])
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4340434&req=5

Figure 1: Colorectal Cancer Carcinogenesis Models (modified after [10])
Mentions: A recent study endorsed the idea that CRC pathogenesis might be induced by transformed CSCs that have the ability to self-renew and to aberrantly differentiate, associating also the interaction between the microenvironment and CR-CSCs [7]. Tumor micro-environment plays an important role in the progression of CRC through the following steps of invasion and metastatic dissemination [8]. Metastasis are a consequence of uncontrolled proliferation of cancer cells group which includes the subpopulation of CR-CSCs [9]. This proliferation process represents the effect of a disequilibrium between the positive and negative angiogenic factors (released by both tumor and host cells), disequilibrium generated by the cancer-stromal cell interaction (Fig.1) [10].

Bottom Line: These alterations will cause the changeover to cancerous stem cells (CSC) having two main characteristics: tumor initiation and maintenance.Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings.Isolation of CR-CSCs can be achieved by targeting and selecting subpopulation of tumor cells based on expression of one or multiple cell surface markers associated with cancer self-renewal, markers as: CD133, CD166, CD44, CD24, beta1 integrin-CD29, Lgr5, EpCAM (ESA), ALDH-1, Msi-1, DCAMLK1 or EphB receptors.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania.

ABSTRACT
: The idea of stem cells as being progenitors of cancer was initially controversial, but later supported by research in the field of leukemia and solid tumors. Afterwards, it was established that genetic abnormalities can affect the stem and progenitor cells, leading to uncontrolled replication and deregulated differentiation. These alterations will cause the changeover to cancerous stem cells (CSC) having two main characteristics: tumor initiation and maintenance. This review will focus on the colorectal cancer stem cell (CR-CSCs) theory which provides a better understanding of different tumor processes: initiation, aggressive growth, recurrence, treatment resistance and metastasis. A search in PubMed/Medline was performed using the following keywords: colorectal cancer stem cells (CR-CSCs), colorectal neoplasms stem cells, colorectal cancer stem cell (CR-CSCs) markers, etc. Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings. Isolation of CR-CSCs can be achieved by targeting and selecting subpopulation of tumor cells based on expression of one or multiple cell surface markers associated with cancer self-renewal, markers as: CD133, CD166, CD44, CD24, beta1 integrin-CD29, Lgr5, EpCAM (ESA), ALDH-1, Msi-1, DCAMLK1 or EphB receptors. The identification and localization of CR-CSCs through different markers will hopefully lead to a better stratification of prognosis and treatment response, as well as the development of new effective strategies for cancer management.

No MeSH data available.


Related in: MedlinePlus