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Voluntary acceptance and consumption of two oral ciclosporin formulations in dogs: two randomised, controlled studies.

Navarro C, Crastes N, Benizeau E, McGahie D - Ir Vet J (2015)

Bottom Line: Many studies have provided substantial evidence of ciclosporin efficacy and safety in canine AD management, and for several years ciclosporin has been recognised as a major component of canine AD multimodal therapy.Immediate prehension (in less than 2 seconds) occurred significantly more often with Cyclavance® (90.6% of the tests) than with Atopica® (14.4% of the tests) when products were mixed with 30 grams of dry food (p < 0.001).By facilitating cicloporin administration and consumption, Cyclavance® liquid formulation offers an interesting alternative to capsules that may improve dosing compliance and therefore the ability to benefit from the therapeutic effects in the long-term treatment of canine AD.

View Article: PubMed Central - PubMed

Affiliation: Medical department, Virbac, 13ème rue LID, 06515 Carros, France.

ABSTRACT

Background: Atopic dermatitis (AD) is the most common canine allergic skin disease and can significantly affect the quality of life of affected dogs. Treating canine AD with ciclosporin has been a subject of great interest in recent years. Many studies have provided substantial evidence of ciclosporin efficacy and safety in canine AD management, and for several years ciclosporin has been recognised as a major component of canine AD multimodal therapy. As a chronic condition, canine AD requires life-long medical management and treatment success relies in large part on product ease of administration. Two studies were conducted to assess the comparative voluntary acceptance and consumption of Cyclavance® (Virbac), a new oral liquid formulation of ciclosporin, and Atopica® (Novartis) either added to a small quantity of kibbles (study 1) or administered directly into the dog's mouth (study 2).

Results: Over the course of the two studies 70 dogs assessed each of the ciclosporin formulations and 320 individual tests were performed for each tested product. Immediate prehension (in less than 2 seconds) occurred significantly more often with Cyclavance® (90.6% of the tests) than with Atopica® (14.4% of the tests) when products were mixed with 30 grams of dry food (p < 0.001). Moreover, Cyclavance® was significantly more often easily accepted than Atopica® (99.3% vs 27.1% of the tests, respectively) when products were administered directly into the dogs' mouth (p < 0.0001). Cyclavance® was also more often totally consumed (98.3% of the tests) than Atopica® (2.2% of the tests) when mixed with a small amount of food (p < 0.001). However, both products were totally consumed once administered directly into the dogs' mouth.

Conclusions: By facilitating cicloporin administration and consumption, Cyclavance® liquid formulation offers an interesting alternative to capsules that may improve dosing compliance and therefore the ability to benefit from the therapeutic effects in the long-term treatment of canine AD.

No MeSH data available.


Related in: MedlinePlus

Product consumption in study 1. This chart presents the level of consumption for the tested products. * Statistical difference between the products (p < 0.05). Total consumption was significantly higher for Cyclavance® than Atopica® (p < 0.001).
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Fig2: Product consumption in study 1. This chart presents the level of consumption for the tested products. * Statistical difference between the products (p < 0.05). Total consumption was significantly higher for Cyclavance® than Atopica® (p < 0.001).

Mentions: Over the course of the study, a total of 180 individual voluntary acceptance tests were completed for each tested product. Figure 1 demonstrates the prehension by category for each product. Immediate prehension rates (product voluntarily taken into the dog’s mouth in less than 2 seconds) were significantly higher for Cyclavance® (163 of 180 tests; 90.6%) compared to Atopica® (26 of 180 tests; 14.4%) (p < 0.001). Table 1 shows the breakdown of prehension rates for each tested product by bodyweight range. The results remain in line with those observed with all dogs independently of their bodyweight. When considering product consumption, a statistically significant difference (p < 0.001) between products was also shown in favour of Cyclavance® with total consumption in 177 tests (98.3%) versus 4 tests (2.2%) for Atopica®. Figure 2 provides the details of the consumption rates by category. In one test (0.6%), a dog consumed partially the dose of Cyclavance®, but in all other tests, the dogs ingested the total amount of liquid with the kibbles. Some dogs took the capsule of Atopica® into their mouth and then spat it out immediately, but the great majority of the dogs did not take the capsule. The dogs’ bodyweight ranges had no impact on consumption for either product as shown in Table 2. Kibbles were totally (100%) consumed for both products. No adverse event was reported during the course of the study for either tested product.Figure 1


Voluntary acceptance and consumption of two oral ciclosporin formulations in dogs: two randomised, controlled studies.

Navarro C, Crastes N, Benizeau E, McGahie D - Ir Vet J (2015)

Product consumption in study 1. This chart presents the level of consumption for the tested products. * Statistical difference between the products (p < 0.05). Total consumption was significantly higher for Cyclavance® than Atopica® (p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4340113&req=5

Fig2: Product consumption in study 1. This chart presents the level of consumption for the tested products. * Statistical difference between the products (p < 0.05). Total consumption was significantly higher for Cyclavance® than Atopica® (p < 0.001).
Mentions: Over the course of the study, a total of 180 individual voluntary acceptance tests were completed for each tested product. Figure 1 demonstrates the prehension by category for each product. Immediate prehension rates (product voluntarily taken into the dog’s mouth in less than 2 seconds) were significantly higher for Cyclavance® (163 of 180 tests; 90.6%) compared to Atopica® (26 of 180 tests; 14.4%) (p < 0.001). Table 1 shows the breakdown of prehension rates for each tested product by bodyweight range. The results remain in line with those observed with all dogs independently of their bodyweight. When considering product consumption, a statistically significant difference (p < 0.001) between products was also shown in favour of Cyclavance® with total consumption in 177 tests (98.3%) versus 4 tests (2.2%) for Atopica®. Figure 2 provides the details of the consumption rates by category. In one test (0.6%), a dog consumed partially the dose of Cyclavance®, but in all other tests, the dogs ingested the total amount of liquid with the kibbles. Some dogs took the capsule of Atopica® into their mouth and then spat it out immediately, but the great majority of the dogs did not take the capsule. The dogs’ bodyweight ranges had no impact on consumption for either product as shown in Table 2. Kibbles were totally (100%) consumed for both products. No adverse event was reported during the course of the study for either tested product.Figure 1

Bottom Line: Many studies have provided substantial evidence of ciclosporin efficacy and safety in canine AD management, and for several years ciclosporin has been recognised as a major component of canine AD multimodal therapy.Immediate prehension (in less than 2 seconds) occurred significantly more often with Cyclavance® (90.6% of the tests) than with Atopica® (14.4% of the tests) when products were mixed with 30 grams of dry food (p < 0.001).By facilitating cicloporin administration and consumption, Cyclavance® liquid formulation offers an interesting alternative to capsules that may improve dosing compliance and therefore the ability to benefit from the therapeutic effects in the long-term treatment of canine AD.

View Article: PubMed Central - PubMed

Affiliation: Medical department, Virbac, 13ème rue LID, 06515 Carros, France.

ABSTRACT

Background: Atopic dermatitis (AD) is the most common canine allergic skin disease and can significantly affect the quality of life of affected dogs. Treating canine AD with ciclosporin has been a subject of great interest in recent years. Many studies have provided substantial evidence of ciclosporin efficacy and safety in canine AD management, and for several years ciclosporin has been recognised as a major component of canine AD multimodal therapy. As a chronic condition, canine AD requires life-long medical management and treatment success relies in large part on product ease of administration. Two studies were conducted to assess the comparative voluntary acceptance and consumption of Cyclavance® (Virbac), a new oral liquid formulation of ciclosporin, and Atopica® (Novartis) either added to a small quantity of kibbles (study 1) or administered directly into the dog's mouth (study 2).

Results: Over the course of the two studies 70 dogs assessed each of the ciclosporin formulations and 320 individual tests were performed for each tested product. Immediate prehension (in less than 2 seconds) occurred significantly more often with Cyclavance® (90.6% of the tests) than with Atopica® (14.4% of the tests) when products were mixed with 30 grams of dry food (p < 0.001). Moreover, Cyclavance® was significantly more often easily accepted than Atopica® (99.3% vs 27.1% of the tests, respectively) when products were administered directly into the dogs' mouth (p < 0.0001). Cyclavance® was also more often totally consumed (98.3% of the tests) than Atopica® (2.2% of the tests) when mixed with a small amount of food (p < 0.001). However, both products were totally consumed once administered directly into the dogs' mouth.

Conclusions: By facilitating cicloporin administration and consumption, Cyclavance® liquid formulation offers an interesting alternative to capsules that may improve dosing compliance and therefore the ability to benefit from the therapeutic effects in the long-term treatment of canine AD.

No MeSH data available.


Related in: MedlinePlus