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Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population: a cross sectional study.

Nell TA, Kruger MJ, Beukes DC, Calitz E, Essop R, Essop MF - BMC Infect. Dis. (2015)

Bottom Line: No significant differences were observed in the male treatment groups.The W:H ratio for the female treatment groups placed the females overall at a higher risk for developing cardiovascular disease compared to the males.We also conclude from this observational study that no significant differences were found in the different male treatment groups.

View Article: PubMed Central - PubMed

Affiliation: Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Mike De Vries Building, Merriman Avenue, Stellenbosch, 7600, South Africa. tnell@sun.ac.za.

ABSTRACT

Background: Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIV-positive individuals. Since there are concerns regarding HAART-mediated onset of cardio-metabolic diseases in the long-term, we evaluated the anthropometric profile of black HIV-infected individuals in a peri-urban setting (Western Cape, South Africa).

Methods: A cross sectional study design was followed to describe the gender differences in different HAART treatment groups. HIV-positive patients (n = 44 males, n = 102 females; 20-40 years) were recruited for three groups: 1) control (HIV-positive, HAART-naïve), 2) HIV-positive (<3 years HAART), and 3) HIV-positive (>3 years HAART).

Results: All participants underwent comprehensive anthropometric and bio-electrical impedance analyses. No significant differences were observed in the male treatment groups. HAART-naïve females are mostly overweight (73.90 ± 2.79). This is followed by a period of muscle wasting seen in the triceps skinfold (29.30 ± 2.19 vs 20.63 ± 1.83; p < 0.01), muscle mass (22.23 ± 0.46 vs 19.82 ± 0.54; p < 0.01), and fat free mass (49.40 ± 1.08 vs 44.16 ± 1.21; p < 0.01) upon HAART initiation (<3 years HAART). Thereafter all parameters measured had levels similar to that seen for the female HAART-naïve group. Females on <3 years HAART exhibited significantly decreased body cell mass (p < 0.01), protein mass (p < 0.01), muscle mass (p < 0.01), fat free mass (p < 0.01), and fat mass (p < 0.001) versus matched HAART-naïve controls. The W:H ratio for the female treatment groups placed the females overall at a higher risk for developing cardiovascular disease compared to the males.

Conclusions: This study found striking gender-based anthropometric differences in black South African HIV-positive individuals on HAART. We also conclude from this observational study that no significant differences were found in the different male treatment groups. All female body composition parameters initially showed lower values (<3 years HAART). The female treatment group (>3 years HAART) displayed values similar to that seen in the HAART-naïve group. Higher W:H ratios in females receiving longer-term HAART potentially increases their risk for the future onset of cardio-metabolic complications.

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Related in: MedlinePlus

BIA characteristics according to gender and treatment. (A) Body cell mass; (B) Fat free mass; and (C) Protein mass (*p < 0.05; **p < 0.01; ***p < 0.001).
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Fig2: BIA characteristics according to gender and treatment. (A) Body cell mass; (B) Fat free mass; and (C) Protein mass (*p < 0.05; **p < 0.01; ***p < 0.001).

Mentions: The BIA analyses showed analogous patterns for the female participants, i.e. lower BCM early on followed by recovery with longer HAART (Figure 2A). A main effect of treatment (p < 0.05), gender (p < 0.001), and treatment and gender (p < 0.05) was evident when BCM was analyzed using factorial ANOVA. Bonferroni post-hoc tests indicated significant differences in the female treatment groups, however, males displayed a higher BCM overall, except for the >3 year group. The FFM data demonstrated a similar arrangement, with effects of treatment (p < 0.05), gender (p < 0.001) and treatment and gender (p < 0.05) (Figure 2B).Figure 2


Distinct gender differences in anthropometric profiles of a peri-urban South African HIV population: a cross sectional study.

Nell TA, Kruger MJ, Beukes DC, Calitz E, Essop R, Essop MF - BMC Infect. Dis. (2015)

BIA characteristics according to gender and treatment. (A) Body cell mass; (B) Fat free mass; and (C) Protein mass (*p < 0.05; **p < 0.01; ***p < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4340112&req=5

Fig2: BIA characteristics according to gender and treatment. (A) Body cell mass; (B) Fat free mass; and (C) Protein mass (*p < 0.05; **p < 0.01; ***p < 0.001).
Mentions: The BIA analyses showed analogous patterns for the female participants, i.e. lower BCM early on followed by recovery with longer HAART (Figure 2A). A main effect of treatment (p < 0.05), gender (p < 0.001), and treatment and gender (p < 0.05) was evident when BCM was analyzed using factorial ANOVA. Bonferroni post-hoc tests indicated significant differences in the female treatment groups, however, males displayed a higher BCM overall, except for the >3 year group. The FFM data demonstrated a similar arrangement, with effects of treatment (p < 0.05), gender (p < 0.001) and treatment and gender (p < 0.05) (Figure 2B).Figure 2

Bottom Line: No significant differences were observed in the male treatment groups.The W:H ratio for the female treatment groups placed the females overall at a higher risk for developing cardiovascular disease compared to the males.We also conclude from this observational study that no significant differences were found in the different male treatment groups.

View Article: PubMed Central - PubMed

Affiliation: Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Mike De Vries Building, Merriman Avenue, Stellenbosch, 7600, South Africa. tnell@sun.ac.za.

ABSTRACT

Background: Highly active antiretroviral therapy (HAART) has extended life expectancy and enhanced the well-being of HIV-positive individuals. Since there are concerns regarding HAART-mediated onset of cardio-metabolic diseases in the long-term, we evaluated the anthropometric profile of black HIV-infected individuals in a peri-urban setting (Western Cape, South Africa).

Methods: A cross sectional study design was followed to describe the gender differences in different HAART treatment groups. HIV-positive patients (n = 44 males, n = 102 females; 20-40 years) were recruited for three groups: 1) control (HIV-positive, HAART-naïve), 2) HIV-positive (<3 years HAART), and 3) HIV-positive (>3 years HAART).

Results: All participants underwent comprehensive anthropometric and bio-electrical impedance analyses. No significant differences were observed in the male treatment groups. HAART-naïve females are mostly overweight (73.90 ± 2.79). This is followed by a period of muscle wasting seen in the triceps skinfold (29.30 ± 2.19 vs 20.63 ± 1.83; p < 0.01), muscle mass (22.23 ± 0.46 vs 19.82 ± 0.54; p < 0.01), and fat free mass (49.40 ± 1.08 vs 44.16 ± 1.21; p < 0.01) upon HAART initiation (<3 years HAART). Thereafter all parameters measured had levels similar to that seen for the female HAART-naïve group. Females on <3 years HAART exhibited significantly decreased body cell mass (p < 0.01), protein mass (p < 0.01), muscle mass (p < 0.01), fat free mass (p < 0.01), and fat mass (p < 0.001) versus matched HAART-naïve controls. The W:H ratio for the female treatment groups placed the females overall at a higher risk for developing cardiovascular disease compared to the males.

Conclusions: This study found striking gender-based anthropometric differences in black South African HIV-positive individuals on HAART. We also conclude from this observational study that no significant differences were found in the different male treatment groups. All female body composition parameters initially showed lower values (<3 years HAART). The female treatment group (>3 years HAART) displayed values similar to that seen in the HAART-naïve group. Higher W:H ratios in females receiving longer-term HAART potentially increases their risk for the future onset of cardio-metabolic complications.

Show MeSH
Related in: MedlinePlus