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The aetiology of community associated pneumonia in children in Nanjing, China and aetiological patterns associated with age and season.

Chen K, Jia R, Li L, Yang C, Shi Y - BMC Public Health (2015)

Bottom Line: The positive percentages of MP, INFB, PIVs and RSV were found to be associated with age, especially MP, INFB and PIVs.The positive percentages of MP, PIVs and RSV were also found to be associated with season.Some pathogens were found to be associated with age and season.

View Article: PubMed Central - PubMed

Affiliation: Zhongda Hospital, Southeast University, 87 Dingjiaqiao, Nanjing, 210009, Jiangsu, China. keping2001@hotmail.com.

ABSTRACT

Background: Viral and atypical bacterial pathogens play an important role in respiratory tract infection. Using the Pneumoslide IgM test, the presented study explored the aetiology of community-acquired pneumonia and investigated further whether there was an association between age or season and aetiological organisms.

Methods: Serum samples, taken between August 2011 and August 2013, from patients with CAP were tested with the Pneumoslide IgM kit. The Pneumoslide IgM technology can simultaneously diagnose 9 viral and atypical bacterial pathogens: Legionella pneumophila serogroup 1 (LP1), Mycoplasma pneumoniae (MP), Coxiella burnetii (COX), Chlamydophila pneumonia (CP), Adenovirus (ADV), Respiratory syncytial virus (RSV), Influenza A (INFA), Influenza B (INFB), Parainfluenza 1, 2 and 3 (PIVs). The data was analyzed by using Statistical Package for the Social Sciences for Windows (SPSS, version 11.0).

Results: Of a total of 1204 serum samples tested, 624 samples were positive. M. pneumoniae was the dominant pathogen, with INFB, PIVs, and RSV ranking second to fourth, respectively. The positive percentages of MP, INFB, PIVs and RSV were found to be associated with age, especially MP, INFB and PIVs. The positive percentages of MP, PIVs and RSV were also found to be associated with season. The positive percentage of MP in autumn was the highest. The positive percentages of LP1 in August and September, ADV in June and INFB in March were relatively higher than that in other months.

Conclusions: The results show there were 4 main viral and atypical bacterial pathogens causing CAP in our study. Some pathogens were found to be associated with age and season. M. pneumoniae was the most predominant pathogen among these 9 pathogens. It is necessary to take preventative measures in order to prevent the spread of these pathogens in susceptible age groups during peak season.

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The positive percentages of ADV from January to December. The positive percentages of ADV in June were higher than in other months.
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Fig3: The positive percentages of ADV from January to December. The positive percentages of ADV in June were higher than in other months.

Mentions: Among the 4 major respiratory tract pathogens, the positive percentages of MP, PIVs and RSV were found to be associated with seasons (MP, p = 0.011; PIVs, p = 0.009; RSV, p = 0.038) but the positive percentage of INFB was not found to be associated with season (p = 0.063) (Table 4). The positive percentage of MP was always high throughout the seasons (>29.63%) (Figure 1), compared to the other 8 pathogens. The positive percentages of MP was relatively high in summer and autumn (45.08% and 47.14% respectively) and relatively low in spring and winter (38.29% and 35.52% respectively) (Table 4). The positive percentages of LP1 in August and September and of ADV in June were higher than in other months (Figures 2 and 3).Table 4


The aetiology of community associated pneumonia in children in Nanjing, China and aetiological patterns associated with age and season.

Chen K, Jia R, Li L, Yang C, Shi Y - BMC Public Health (2015)

The positive percentages of ADV from January to December. The positive percentages of ADV in June were higher than in other months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4340102&req=5

Fig3: The positive percentages of ADV from January to December. The positive percentages of ADV in June were higher than in other months.
Mentions: Among the 4 major respiratory tract pathogens, the positive percentages of MP, PIVs and RSV were found to be associated with seasons (MP, p = 0.011; PIVs, p = 0.009; RSV, p = 0.038) but the positive percentage of INFB was not found to be associated with season (p = 0.063) (Table 4). The positive percentage of MP was always high throughout the seasons (>29.63%) (Figure 1), compared to the other 8 pathogens. The positive percentages of MP was relatively high in summer and autumn (45.08% and 47.14% respectively) and relatively low in spring and winter (38.29% and 35.52% respectively) (Table 4). The positive percentages of LP1 in August and September and of ADV in June were higher than in other months (Figures 2 and 3).Table 4

Bottom Line: The positive percentages of MP, INFB, PIVs and RSV were found to be associated with age, especially MP, INFB and PIVs.The positive percentages of MP, PIVs and RSV were also found to be associated with season.Some pathogens were found to be associated with age and season.

View Article: PubMed Central - PubMed

Affiliation: Zhongda Hospital, Southeast University, 87 Dingjiaqiao, Nanjing, 210009, Jiangsu, China. keping2001@hotmail.com.

ABSTRACT

Background: Viral and atypical bacterial pathogens play an important role in respiratory tract infection. Using the Pneumoslide IgM test, the presented study explored the aetiology of community-acquired pneumonia and investigated further whether there was an association between age or season and aetiological organisms.

Methods: Serum samples, taken between August 2011 and August 2013, from patients with CAP were tested with the Pneumoslide IgM kit. The Pneumoslide IgM technology can simultaneously diagnose 9 viral and atypical bacterial pathogens: Legionella pneumophila serogroup 1 (LP1), Mycoplasma pneumoniae (MP), Coxiella burnetii (COX), Chlamydophila pneumonia (CP), Adenovirus (ADV), Respiratory syncytial virus (RSV), Influenza A (INFA), Influenza B (INFB), Parainfluenza 1, 2 and 3 (PIVs). The data was analyzed by using Statistical Package for the Social Sciences for Windows (SPSS, version 11.0).

Results: Of a total of 1204 serum samples tested, 624 samples were positive. M. pneumoniae was the dominant pathogen, with INFB, PIVs, and RSV ranking second to fourth, respectively. The positive percentages of MP, INFB, PIVs and RSV were found to be associated with age, especially MP, INFB and PIVs. The positive percentages of MP, PIVs and RSV were also found to be associated with season. The positive percentage of MP in autumn was the highest. The positive percentages of LP1 in August and September, ADV in June and INFB in March were relatively higher than that in other months.

Conclusions: The results show there were 4 main viral and atypical bacterial pathogens causing CAP in our study. Some pathogens were found to be associated with age and season. M. pneumoniae was the most predominant pathogen among these 9 pathogens. It is necessary to take preventative measures in order to prevent the spread of these pathogens in susceptible age groups during peak season.

Show MeSH
Related in: MedlinePlus