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ROSics: chemistry and proteomics of cysteine modifications in redox biology.

Kim HJ, Ha S, Lee HY, Lee KJ - Mass Spectrom Rev (2014)

Bottom Line: Proteomic tools are available to identify PTMs and have proved invaluable to expanding the inventory of these tools of nature that hold the keys to biological processes.We present here, a review of relevant ROS biology, possible chemical reactions of Cys residues and details of the proteomic strategies employed for rapid, efficient and sensitive identification of diverse and novel PTMs involving reactive Cys residues of redox-sensitive proteins.We propose a new name, "ROSics," for the science which describes the principles of mode of action of ROS at molecular levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.

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Nucleophilic reactions of thiolate to form disulfide.
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sch11: Nucleophilic reactions of thiolate to form disulfide.


ROSics: chemistry and proteomics of cysteine modifications in redox biology.

Kim HJ, Ha S, Lee HY, Lee KJ - Mass Spectrom Rev (2014)

Nucleophilic reactions of thiolate to form disulfide.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4340047&req=5

sch11: Nucleophilic reactions of thiolate to form disulfide.
Bottom Line: Proteomic tools are available to identify PTMs and have proved invaluable to expanding the inventory of these tools of nature that hold the keys to biological processes.We present here, a review of relevant ROS biology, possible chemical reactions of Cys residues and details of the proteomic strategies employed for rapid, efficient and sensitive identification of diverse and novel PTMs involving reactive Cys residues of redox-sensitive proteins.We propose a new name, "ROSics," for the science which describes the principles of mode of action of ROS at molecular levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.

Show MeSH
Related in: MedlinePlus