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ROSics: chemistry and proteomics of cysteine modifications in redox biology.

Kim HJ, Ha S, Lee HY, Lee KJ - Mass Spectrom Rev (2014)

Bottom Line: It is therefore necessary to identify the Cys-containing ROS target proteins, as well as the sites and species of their PTMs. Cutting edge proteomic tools which have helped identify the PTMs at reactive Cys residues, have also revealed that Cys residues are modified in numerous ways.We present here, a review of relevant ROS biology, possible chemical reactions of Cys residues and details of the proteomic strategies employed for rapid, efficient and sensitive identification of diverse and novel PTMs involving reactive Cys residues of redox-sensitive proteins.We propose a new name, "ROSics," for the science which describes the principles of mode of action of ROS at molecular levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.

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Nucleophilic reactions of thiolate to form disulfide.
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sch11: Nucleophilic reactions of thiolate to form disulfide.


ROSics: chemistry and proteomics of cysteine modifications in redox biology.

Kim HJ, Ha S, Lee HY, Lee KJ - Mass Spectrom Rev (2014)

Nucleophilic reactions of thiolate to form disulfide.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4340047&req=5

sch11: Nucleophilic reactions of thiolate to form disulfide.
Bottom Line: It is therefore necessary to identify the Cys-containing ROS target proteins, as well as the sites and species of their PTMs. Cutting edge proteomic tools which have helped identify the PTMs at reactive Cys residues, have also revealed that Cys residues are modified in numerous ways.We present here, a review of relevant ROS biology, possible chemical reactions of Cys residues and details of the proteomic strategies employed for rapid, efficient and sensitive identification of diverse and novel PTMs involving reactive Cys residues of redox-sensitive proteins.We propose a new name, "ROSics," for the science which describes the principles of mode of action of ROS at molecular levels.

View Article: PubMed Central - PubMed

Affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.

Show MeSH
Related in: MedlinePlus