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Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment: A functional magnetic resonance imaging study.

Jiang W, Yin Z, Pang Y, Wu F, Kong L, Xu K - Neural Regen Res (2012)

Bottom Line: Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition.After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition.Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, the First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.

ABSTRACT
Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.

No MeSH data available.


Related in: MedlinePlus

Regions showing significantly increased activation during sad facial emotion recognition after treatment.The median sagittal, coronal, sagittal and axial views of the brain are shown. The color bar represents the range of t values.
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Figure 2: Regions showing significantly increased activation during sad facial emotion recognition after treatment.The median sagittal, coronal, sagittal and axial views of the brain are shown. The color bar represents the range of t values.

Mentions: Significantly reduced activation during sad facial emotion recognition was observed in a number brain regions after treatment (Figure 1), including the bilateral anterior central gyrus within the frontal lobe, the bilateral gyrus frontalis medius, the left gyrus temporalis medius, the bilateral gyrus centralis posterior within the apical lobe, the left callosal gyrus and the right subiculum hippocampi. Accordingly, activation in the bilateral parietal lobule and the left gyrus pulvinar medius was significantly increased during the recognition of sad facial expressions after treatment (Figures 1, 2; Table 2).


Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment: A functional magnetic resonance imaging study.

Jiang W, Yin Z, Pang Y, Wu F, Kong L, Xu K - Neural Regen Res (2012)

Regions showing significantly increased activation during sad facial emotion recognition after treatment.The median sagittal, coronal, sagittal and axial views of the brain are shown. The color bar represents the range of t values.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4340032&req=5

Figure 2: Regions showing significantly increased activation during sad facial emotion recognition after treatment.The median sagittal, coronal, sagittal and axial views of the brain are shown. The color bar represents the range of t values.
Mentions: Significantly reduced activation during sad facial emotion recognition was observed in a number brain regions after treatment (Figure 1), including the bilateral anterior central gyrus within the frontal lobe, the bilateral gyrus frontalis medius, the left gyrus temporalis medius, the bilateral gyrus centralis posterior within the apical lobe, the left callosal gyrus and the right subiculum hippocampi. Accordingly, activation in the bilateral parietal lobule and the left gyrus pulvinar medius was significantly increased during the recognition of sad facial expressions after treatment (Figures 1, 2; Table 2).

Bottom Line: Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition.After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition.Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, the First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China.

ABSTRACT
Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.

No MeSH data available.


Related in: MedlinePlus