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Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity.

Zhao C, Qi L, Wu L, Yi T, Wu H, Guo X, Zhou C, Liu H, Wang X - Neural Regen Res (2012)

Bottom Line: Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia.This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity.Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased.

View Article: PubMed Central - PubMed

Affiliation: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

ABSTRACT
Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia.

No MeSH data available.


Related in: MedlinePlus

Prokineticin 1 and prokineticin receptor 1 expression in spinal cord from chronic visceral hypersensitivity rats (immunohistochemistry, × 400). Prokineticin 1 and prokineticin receptor 1 positive cells (stained yellow; arrows) were visible in each group. The expression of positive products was increased in the model group showing dark staining, while staining was light and attenuated in the suspended moxibustion and normal groups.
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Figure 2: Prokineticin 1 and prokineticin receptor 1 expression in spinal cord from chronic visceral hypersensitivity rats (immunohistochemistry, × 400). Prokineticin 1 and prokineticin receptor 1 positive cells (stained yellow; arrows) were visible in each group. The expression of positive products was increased in the model group showing dark staining, while staining was light and attenuated in the suspended moxibustion and normal groups.

Mentions: Immunohistochemistry revealed that the expression level of PK1 and PKR1 was significantly higher in the model group than the normal group (P < 0.01). PK1 and PKR1 expression was significantly decreased in the suspended moxibustion group compared with the model group (P < 0.01; Figure 2, Table 1).


Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity.

Zhao C, Qi L, Wu L, Yi T, Wu H, Guo X, Zhou C, Liu H, Wang X - Neural Regen Res (2012)

Prokineticin 1 and prokineticin receptor 1 expression in spinal cord from chronic visceral hypersensitivity rats (immunohistochemistry, × 400). Prokineticin 1 and prokineticin receptor 1 positive cells (stained yellow; arrows) were visible in each group. The expression of positive products was increased in the model group showing dark staining, while staining was light and attenuated in the suspended moxibustion and normal groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4340031&req=5

Figure 2: Prokineticin 1 and prokineticin receptor 1 expression in spinal cord from chronic visceral hypersensitivity rats (immunohistochemistry, × 400). Prokineticin 1 and prokineticin receptor 1 positive cells (stained yellow; arrows) were visible in each group. The expression of positive products was increased in the model group showing dark staining, while staining was light and attenuated in the suspended moxibustion and normal groups.
Mentions: Immunohistochemistry revealed that the expression level of PK1 and PKR1 was significantly higher in the model group than the normal group (P < 0.01). PK1 and PKR1 expression was significantly decreased in the suspended moxibustion group compared with the model group (P < 0.01; Figure 2, Table 1).

Bottom Line: Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia.This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity.Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased.

View Article: PubMed Central - PubMed

Affiliation: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

ABSTRACT
Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia.

No MeSH data available.


Related in: MedlinePlus