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Report of two cases of anti-M antibody in antenatal patients.

Philip J, Kushwaha N, Jain N - Asian J Transfus Sci (2015 Jan-Jun)

Bottom Line: Anti-M is a relatively common naturally occurring antibody reacting optimally at 4°C and weakly or nonreactive at 37°C.It is usually clinically insignificant but can be active at 37°C because of thermal amplitude of IgM component or presence of IgG component.At our center we have encountered two cases of anti-M antibodies- one presenting as crossmatch incompatibility and other as blood grouping discrepancy in the last 8 months.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion Medicine, Armed Forces Medical College, Pune, Maharashtra, India.

ABSTRACT
Anti-M is a relatively common naturally occurring antibody reacting optimally at 4°C and weakly or nonreactive at 37°C. It is usually clinically insignificant but can be active at 37°C because of thermal amplitude of IgM component or presence of IgG component. It can cause or delayed hemolytic transfusion reactions or hemolytic disease of newborn. At our center we have encountered two cases of anti-M antibodies- one presenting as crossmatch incompatibility and other as blood grouping discrepancy in the last 8 months.

No MeSH data available.


Related in: MedlinePlus

LISS Coomb's gel card showing one to 11-cell panel antibody identification results at 37°C
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Figure 2: LISS Coomb's gel card showing one to 11-cell panel antibody identification results at 37°C

Mentions: Anti-e, anti-Jka, anti-M, and anti-S were considered as differential diagnosis. For antibody identification, 11-cell panel (Biorad-ID Micro typing system) was used, which identified anti-M Ab [Figure 2].


Report of two cases of anti-M antibody in antenatal patients.

Philip J, Kushwaha N, Jain N - Asian J Transfus Sci (2015 Jan-Jun)

LISS Coomb's gel card showing one to 11-cell panel antibody identification results at 37°C
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4339943&req=5

Figure 2: LISS Coomb's gel card showing one to 11-cell panel antibody identification results at 37°C
Mentions: Anti-e, anti-Jka, anti-M, and anti-S were considered as differential diagnosis. For antibody identification, 11-cell panel (Biorad-ID Micro typing system) was used, which identified anti-M Ab [Figure 2].

Bottom Line: Anti-M is a relatively common naturally occurring antibody reacting optimally at 4°C and weakly or nonreactive at 37°C.It is usually clinically insignificant but can be active at 37°C because of thermal amplitude of IgM component or presence of IgG component.At our center we have encountered two cases of anti-M antibodies- one presenting as crossmatch incompatibility and other as blood grouping discrepancy in the last 8 months.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion Medicine, Armed Forces Medical College, Pune, Maharashtra, India.

ABSTRACT
Anti-M is a relatively common naturally occurring antibody reacting optimally at 4°C and weakly or nonreactive at 37°C. It is usually clinically insignificant but can be active at 37°C because of thermal amplitude of IgM component or presence of IgG component. It can cause or delayed hemolytic transfusion reactions or hemolytic disease of newborn. At our center we have encountered two cases of anti-M antibodies- one presenting as crossmatch incompatibility and other as blood grouping discrepancy in the last 8 months.

No MeSH data available.


Related in: MedlinePlus