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A cost effective model for appropriate administration of red cell units and salvaging un-transfused red cell units by using temperature sensitive indicators for blood component transportation in a hospital setting.

Tiwari AK, Sharma P, Pandey PK, Rawat GS, Dixit S, Raina V, Bhargava R - Asian J Transfus Sci (2015 Jan-Jun)

Bottom Line: Statistically insignificant elevation in average temperature was noted in 102 simulated units at the time of return to BTS (Δ 0.04°C), despite the fact that these units were in the transport box for over 4 h.The average supernatant hemoglobin in these units was 0.24%, much below the prescribed threshold.Transportation of blood in controlled conditions with temperature-sensitive indicator is a cost-effective model to save blood, a precious human resource.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion Medicine, Medanta-The Medicity, Gurgaon, Haryana, India.

ABSTRACT

Background: A rule called "30-min rule" defines that red cell unit cannot be used if it has been out of blood bank refrigerator for over 30 min. This rule is useful to guide initiation of transfusion, but is inadequate for deciding whether to reuse or discard units received-back at blood transfusion services (BTS). A simple cost-effective temperature-sensitive indicator was evaluated to decide upon reuse (cold chain was uninterrupted) or discard (where cold chain was interrupted) in a simulation exercise.

Materials and methods: Temperature-sensitive indicators TH-F™ that irreversibly changed color from white to red demonstrated that heat excursion has occurred and the cumulative temperature has exceeded 10°C for over 30 min, were used in outdated red cells for simulating units, which are not used and received-back. These units were also tagged with a standard temperature monitoring device, which was a re-usable credit card sized device, which would log the actual time and temperature. In few units percent hemolysis was also calculated.

Results: Statistically insignificant elevation in average temperature was noted in 102 simulated units at the time of return to BTS (Δ 0.04°C), despite the fact that these units were in the transport box for over 4 h. The average supernatant hemoglobin in these units was 0.24%, much below the prescribed threshold.

Conclusion: Transportation of blood in controlled conditions with temperature-sensitive indicator is a cost-effective model to save blood, a precious human resource.

No MeSH data available.


Related in: MedlinePlus

Standard temperature monitoring system and its reader
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Figure 2: Standard temperature monitoring system and its reader

Mentions: TH-F™ was a single-use time delay threshold Indicator (Temptime Corporation, US) that irreversibly changed color from white to red to signal that a cumulative heat excursion at 9°C for 2 h or less has occurred. The typical time for TH-F to respond at 9°C is about 30 min. This time period will vary from 30 to 180 min depending on the temperature of heat excursion; a higher temperature of say 25°C may change the color in 20 min, while 9°C may do so in 150 min. This is based on a technology where paraffin compounds (crystalline alkyl hydrocarbons) change from solid to liquid. This is formulated to melt at a designated temperature (9°C) which is displayed by a color change from white to red. This temperature indicator is fixed on the surface of the blood bag. The color-change signals that a potentially damaging temperature has been reached. It is easy to read and easy to understand with the color changing from white to red. It does not require any activation and there is no known toxicity of active materials used in product. Temptime Corporation's quality management system is consistent with Food and Drug Administration Quality System Requirement 21 CFR 820 (GMP for medical devices).


A cost effective model for appropriate administration of red cell units and salvaging un-transfused red cell units by using temperature sensitive indicators for blood component transportation in a hospital setting.

Tiwari AK, Sharma P, Pandey PK, Rawat GS, Dixit S, Raina V, Bhargava R - Asian J Transfus Sci (2015 Jan-Jun)

Standard temperature monitoring system and its reader
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4339929&req=5

Figure 2: Standard temperature monitoring system and its reader
Mentions: TH-F™ was a single-use time delay threshold Indicator (Temptime Corporation, US) that irreversibly changed color from white to red to signal that a cumulative heat excursion at 9°C for 2 h or less has occurred. The typical time for TH-F to respond at 9°C is about 30 min. This time period will vary from 30 to 180 min depending on the temperature of heat excursion; a higher temperature of say 25°C may change the color in 20 min, while 9°C may do so in 150 min. This is based on a technology where paraffin compounds (crystalline alkyl hydrocarbons) change from solid to liquid. This is formulated to melt at a designated temperature (9°C) which is displayed by a color change from white to red. This temperature indicator is fixed on the surface of the blood bag. The color-change signals that a potentially damaging temperature has been reached. It is easy to read and easy to understand with the color changing from white to red. It does not require any activation and there is no known toxicity of active materials used in product. Temptime Corporation's quality management system is consistent with Food and Drug Administration Quality System Requirement 21 CFR 820 (GMP for medical devices).

Bottom Line: Statistically insignificant elevation in average temperature was noted in 102 simulated units at the time of return to BTS (Δ 0.04°C), despite the fact that these units were in the transport box for over 4 h.The average supernatant hemoglobin in these units was 0.24%, much below the prescribed threshold.Transportation of blood in controlled conditions with temperature-sensitive indicator is a cost-effective model to save blood, a precious human resource.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion Medicine, Medanta-The Medicity, Gurgaon, Haryana, India.

ABSTRACT

Background: A rule called "30-min rule" defines that red cell unit cannot be used if it has been out of blood bank refrigerator for over 30 min. This rule is useful to guide initiation of transfusion, but is inadequate for deciding whether to reuse or discard units received-back at blood transfusion services (BTS). A simple cost-effective temperature-sensitive indicator was evaluated to decide upon reuse (cold chain was uninterrupted) or discard (where cold chain was interrupted) in a simulation exercise.

Materials and methods: Temperature-sensitive indicators TH-F™ that irreversibly changed color from white to red demonstrated that heat excursion has occurred and the cumulative temperature has exceeded 10°C for over 30 min, were used in outdated red cells for simulating units, which are not used and received-back. These units were also tagged with a standard temperature monitoring device, which was a re-usable credit card sized device, which would log the actual time and temperature. In few units percent hemolysis was also calculated.

Results: Statistically insignificant elevation in average temperature was noted in 102 simulated units at the time of return to BTS (Δ 0.04°C), despite the fact that these units were in the transport box for over 4 h. The average supernatant hemoglobin in these units was 0.24%, much below the prescribed threshold.

Conclusion: Transportation of blood in controlled conditions with temperature-sensitive indicator is a cost-effective model to save blood, a precious human resource.

No MeSH data available.


Related in: MedlinePlus