In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography.
Bottom Line: The number of nerve-lesion voxels was significantly higher at thigh level compared to more distal levels (lower leg/ankle) of the lower extremities (f-value = 279.22, P < 0.0001).Further signal-quantification at this proximal site (thigh level) revealed a significant increase of proton-density (P < 0.0001) and T2-relaxation-time (P = 0.0011) in symptomatic patients, whereas asymptomatic gene-carriers presented with a significant increase of proton-density only.Although symptoms start and prevail distally, the focus of predominant nerve injury and injury progression was found proximally at thigh level with strong and unambiguous lesion-contrast.
Affiliation: 1 Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany 2 Amyloidosis Centre Heidelberg, University of Heidelberg, Heidelberg, Germany firstname.lastname@example.org.Show MeSH
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Mentions: One-way ANOVA also revealed significant differences between groups for the apparent T2-relaxation-time T2app (f-value = 7.64; P = 0.0011). Post hoc comparisons showed that T2app was significantly increased only in symptomatic disease (symptomatic TTR-FAP 103.92 ± 6.4 ms versus asymptomatic gene carriers 79.14 ± 1.8 ms, P = 0.012 and versus healthy controls 84.08 ± 2.54 ms, P = 0.003; both P-values Scheffé corrected). However, no significant difference of T2app was observed between asymptomatic gene carriers and controls (P = 0.783). Mean ρ and T2app are plotted for each group in Fig. 3.Figure 3
Affiliation: 1 Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany 2 Amyloidosis Centre Heidelberg, University of Heidelberg, Heidelberg, Germany email@example.com.