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In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography.

Kollmer J, Hund E, Hornung B, Hegenbart U, Schönland SO, Kimmich C, Kristen AV, Purrucker J, Röcken C, Heiland S, Bendszus M, Pham M - Brain (2014)

Bottom Line: It was also higher in asymptomatic carriers compared to controls (P = 0.043).The number of nerve-lesion voxels was significantly higher at thigh level compared to more distal levels (lower leg/ankle) of the lower extremities (f-value = 279.22, P < 0.0001).Further signal-quantification at this proximal site (thigh level) revealed a significant increase of proton-density (P < 0.0001) and T2-relaxation-time (P = 0.0011) in symptomatic patients, whereas asymptomatic gene-carriers presented with a significant increase of proton-density only.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany 2 Amyloidosis Centre Heidelberg, University of Heidelberg, Heidelberg, Germany jennifer.kollmer@med.uni-heidelberg.de.

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Signal quantification. Quantification of mean proton spin density (ρ) and T2 relaxation time (T2app) at thigh level, the site of predominant lesion focus plotted for each group. Differences in ρ (left) were highly significant between all three groups: manifest TTR-FAP versus asymptomatic gene carriers (P = 0.002); manifest TTR-FAP versus controls (P < 0.0001); asymptomatic gene carriers versus controls (P = 0.004). Significant differences were also found in T2app between manifest TTR-FAP and asymptomatic gene carriers (P = 0.003) and between manifest TTR-FAP and controls (P = 0.0011) but not between asymptomatic gene carriers and controls (P = 0.783), indicating that ρ has higher sensitivity in detecting early nerve injury, whereas T2app may better differentiate between increasing severity of clinical nerve impairment. TTR+-FAP+ = manifest/symptomatic TTR-FAP; TTR+-FAP− = asymptomatic gene carriers.
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awu344-F3: Signal quantification. Quantification of mean proton spin density (ρ) and T2 relaxation time (T2app) at thigh level, the site of predominant lesion focus plotted for each group. Differences in ρ (left) were highly significant between all three groups: manifest TTR-FAP versus asymptomatic gene carriers (P = 0.002); manifest TTR-FAP versus controls (P < 0.0001); asymptomatic gene carriers versus controls (P = 0.004). Significant differences were also found in T2app between manifest TTR-FAP and asymptomatic gene carriers (P = 0.003) and between manifest TTR-FAP and controls (P = 0.0011) but not between asymptomatic gene carriers and controls (P = 0.783), indicating that ρ has higher sensitivity in detecting early nerve injury, whereas T2app may better differentiate between increasing severity of clinical nerve impairment. TTR+-FAP+ = manifest/symptomatic TTR-FAP; TTR+-FAP− = asymptomatic gene carriers.

Mentions: One-way ANOVA also revealed significant differences between groups for the apparent T2-relaxation-time T2app (f-value = 7.64; P = 0.0011). Post hoc comparisons showed that T2app was significantly increased only in symptomatic disease (symptomatic TTR-FAP 103.92 ± 6.4 ms versus asymptomatic gene carriers 79.14 ± 1.8 ms, P = 0.012 and versus healthy controls 84.08 ± 2.54 ms, P = 0.003; both P-values Scheffé corrected). However, no significant difference of T2app was observed between asymptomatic gene carriers and controls (P = 0.783). Mean ρ and T2app are plotted for each group in Fig. 3.Figure 3


In vivo detection of nerve injury in familial amyloid polyneuropathy by magnetic resonance neurography.

Kollmer J, Hund E, Hornung B, Hegenbart U, Schönland SO, Kimmich C, Kristen AV, Purrucker J, Röcken C, Heiland S, Bendszus M, Pham M - Brain (2014)

Signal quantification. Quantification of mean proton spin density (ρ) and T2 relaxation time (T2app) at thigh level, the site of predominant lesion focus plotted for each group. Differences in ρ (left) were highly significant between all three groups: manifest TTR-FAP versus asymptomatic gene carriers (P = 0.002); manifest TTR-FAP versus controls (P < 0.0001); asymptomatic gene carriers versus controls (P = 0.004). Significant differences were also found in T2app between manifest TTR-FAP and asymptomatic gene carriers (P = 0.003) and between manifest TTR-FAP and controls (P = 0.0011) but not between asymptomatic gene carriers and controls (P = 0.783), indicating that ρ has higher sensitivity in detecting early nerve injury, whereas T2app may better differentiate between increasing severity of clinical nerve impairment. TTR+-FAP+ = manifest/symptomatic TTR-FAP; TTR+-FAP− = asymptomatic gene carriers.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4339768&req=5

awu344-F3: Signal quantification. Quantification of mean proton spin density (ρ) and T2 relaxation time (T2app) at thigh level, the site of predominant lesion focus plotted for each group. Differences in ρ (left) were highly significant between all three groups: manifest TTR-FAP versus asymptomatic gene carriers (P = 0.002); manifest TTR-FAP versus controls (P < 0.0001); asymptomatic gene carriers versus controls (P = 0.004). Significant differences were also found in T2app between manifest TTR-FAP and asymptomatic gene carriers (P = 0.003) and between manifest TTR-FAP and controls (P = 0.0011) but not between asymptomatic gene carriers and controls (P = 0.783), indicating that ρ has higher sensitivity in detecting early nerve injury, whereas T2app may better differentiate between increasing severity of clinical nerve impairment. TTR+-FAP+ = manifest/symptomatic TTR-FAP; TTR+-FAP− = asymptomatic gene carriers.
Mentions: One-way ANOVA also revealed significant differences between groups for the apparent T2-relaxation-time T2app (f-value = 7.64; P = 0.0011). Post hoc comparisons showed that T2app was significantly increased only in symptomatic disease (symptomatic TTR-FAP 103.92 ± 6.4 ms versus asymptomatic gene carriers 79.14 ± 1.8 ms, P = 0.012 and versus healthy controls 84.08 ± 2.54 ms, P = 0.003; both P-values Scheffé corrected). However, no significant difference of T2app was observed between asymptomatic gene carriers and controls (P = 0.783). Mean ρ and T2app are plotted for each group in Fig. 3.Figure 3

Bottom Line: It was also higher in asymptomatic carriers compared to controls (P = 0.043).The number of nerve-lesion voxels was significantly higher at thigh level compared to more distal levels (lower leg/ankle) of the lower extremities (f-value = 279.22, P < 0.0001).Further signal-quantification at this proximal site (thigh level) revealed a significant increase of proton-density (P < 0.0001) and T2-relaxation-time (P = 0.0011) in symptomatic patients, whereas asymptomatic gene-carriers presented with a significant increase of proton-density only.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany 2 Amyloidosis Centre Heidelberg, University of Heidelberg, Heidelberg, Germany jennifer.kollmer@med.uni-heidelberg.de.

Show MeSH
Related in: MedlinePlus