Limits...
Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.

Pujades-Rodriguez M, George J, Shah AD, Rapsomaniki E, Denaxas S, West R, Smeeth L, Timmis A, Hemingway H - Int J Epidemiol (2014)

Bottom Line: Population-attributable fractions were lower for women than men for unheralded coronary death, ischaemic stroke, PAD and AAA.Ten years after quitting smoking, the risks of PAD, AAA (in men) and unheralded coronary death remained increased (HR=1.36, 1.47 and 2.74, respectively).The heterogeneous associations of smoking with different CVD presentations suggests different underlying mechanisms and have important implications for research, clinical screening and risk prediction.

View Article: PubMed Central - PubMed

Affiliation: Farr Institute of Health Informatics Research, University College London, London, UK, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK and National Institute for Health Research, Biomedical Research Unit, Barts Health NHS Trust, London, UK mar.pujades@ucl.ac.uk.

Show MeSH

Related in: MedlinePlus

Age-adjusted hazard ratios of 12 CVDs comparing current vs never smokers in men and women. Cardiac arrest/SCD, cardiac arrest, ventricular fibrillation and sudden cardiac death; CI, confidence interval; HR, age-adjusted hazard ratio from Cox proportional hazard models with baseline hazard function stratified by general practice and adjusted for baseline age (linear and quadratic terms). *P-value for interaction ≤0.05 (P = 0.05 for myocardial infarction and P = 0.0005 for peripheral arterial disease).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4339760&req=5

dyu218-F3: Age-adjusted hazard ratios of 12 CVDs comparing current vs never smokers in men and women. Cardiac arrest/SCD, cardiac arrest, ventricular fibrillation and sudden cardiac death; CI, confidence interval; HR, age-adjusted hazard ratio from Cox proportional hazard models with baseline hazard function stratified by general practice and adjusted for baseline age (linear and quadratic terms). *P-value for interaction ≤0.05 (P = 0.05 for myocardial infarction and P = 0.0005 for peripheral arterial disease).

Mentions: The relationship between current smoking and PAD was stronger in men than in women (adjusted HR = 5.72, 95% CI 5.24–6.24; compared with 4.17, 95% CI 3.68–4.73; interaction P-value 0.0005; see Figure 3). In contrast, current smoking showed stronger associations among women than in men for MI (adjusted HR = 2.51, 95% CI 2.35–2.73 vs 2.18, 95% CI 2.03–2.32; interaction P-value 0.05).Figure 3.


Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.

Pujades-Rodriguez M, George J, Shah AD, Rapsomaniki E, Denaxas S, West R, Smeeth L, Timmis A, Hemingway H - Int J Epidemiol (2014)

Age-adjusted hazard ratios of 12 CVDs comparing current vs never smokers in men and women. Cardiac arrest/SCD, cardiac arrest, ventricular fibrillation and sudden cardiac death; CI, confidence interval; HR, age-adjusted hazard ratio from Cox proportional hazard models with baseline hazard function stratified by general practice and adjusted for baseline age (linear and quadratic terms). *P-value for interaction ≤0.05 (P = 0.05 for myocardial infarction and P = 0.0005 for peripheral arterial disease).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4339760&req=5

dyu218-F3: Age-adjusted hazard ratios of 12 CVDs comparing current vs never smokers in men and women. Cardiac arrest/SCD, cardiac arrest, ventricular fibrillation and sudden cardiac death; CI, confidence interval; HR, age-adjusted hazard ratio from Cox proportional hazard models with baseline hazard function stratified by general practice and adjusted for baseline age (linear and quadratic terms). *P-value for interaction ≤0.05 (P = 0.05 for myocardial infarction and P = 0.0005 for peripheral arterial disease).
Mentions: The relationship between current smoking and PAD was stronger in men than in women (adjusted HR = 5.72, 95% CI 5.24–6.24; compared with 4.17, 95% CI 3.68–4.73; interaction P-value 0.0005; see Figure 3). In contrast, current smoking showed stronger associations among women than in men for MI (adjusted HR = 2.51, 95% CI 2.35–2.73 vs 2.18, 95% CI 2.03–2.32; interaction P-value 0.05).Figure 3.

Bottom Line: Population-attributable fractions were lower for women than men for unheralded coronary death, ischaemic stroke, PAD and AAA.Ten years after quitting smoking, the risks of PAD, AAA (in men) and unheralded coronary death remained increased (HR=1.36, 1.47 and 2.74, respectively).The heterogeneous associations of smoking with different CVD presentations suggests different underlying mechanisms and have important implications for research, clinical screening and risk prediction.

View Article: PubMed Central - PubMed

Affiliation: Farr Institute of Health Informatics Research, University College London, London, UK, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK and National Institute for Health Research, Biomedical Research Unit, Barts Health NHS Trust, London, UK mar.pujades@ucl.ac.uk.

Show MeSH
Related in: MedlinePlus