Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?
Bottom Line: Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy.A majority (n=62) underwent aortic valve replacement, with fewer undergoing coronary artery bypass grafting (n=34) or mitral valve replacement/repair (n=24).PAOs are frequently detected in human atrium, where their presence is associated with clinical hypertension.
Affiliation: Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (T.N.S., L.C.M., L.V.Y., J.K.P., N.J.B., J.V.B., K.T.M.).Show MeSH
Related in: MedlinePlus
Mentions: To ensure that the A‐11 antibody was detecting protein oligomers and not amyloid fibrils, Congo red staining was performed on 16 patient samples representing a range of mean G/R values (0.03±0.02 to 0.43±0.06). Examination of all Congo red–stained sections under polarized light revealed no evidence of amyloid deposition (Figure 3B). These results further confirm that the protein oligomers identified in the atrial samples are not mature amyloid, given the negative Congo red staining.
Affiliation: Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (T.N.S., L.C.M., L.V.Y., J.K.P., N.J.B., J.V.B., K.T.M.).