Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?
Bottom Line: Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy.A majority (n=62) underwent aortic valve replacement, with fewer undergoing coronary artery bypass grafting (n=34) or mitral valve replacement/repair (n=24).PAOs are frequently detected in human atrium, where their presence is associated with clinical hypertension.
Affiliation: Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (T.N.S., L.C.M., L.V.Y., J.K.P., N.J.B., J.V.B., K.T.M.).Show MeSH
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Mentions: For G/R values, data from different patients were assumed to be statistically independent, whereas those within a patient were correlated. Data inspection revealed that the individual field G/R values of the 92 patients did not have homogeneous variance (Figure 2). Therefore, we used a linear mixed‐effects model with random effect of study subject to handle the heterogeneity of variances within a patient. The correlation structure was based on the compound symmetry structure. The focus of the multivariable data analysis was to study the potential association between PAO burden, expressed as G/R values, and specific clinical variables, including age, sex, hypertension, body mass index, β‐blocker therapy, atrial source, and cardiac substrate (specifically aortic valve [AV] replacement). The general linear model analysis was used to study the correlation between G/R values and percent fibrosis. The statistical tests for model parameters were 2‐sided with a statistically significant level of .05. All statistical analysis was performed using R nlme package with version 2.14.1 for Windows.
Affiliation: Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (T.N.S., L.C.M., L.V.Y., J.K.P., N.J.B., J.V.B., K.T.M.).