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Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?

Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT - J Am Heart Assoc (2014)

Bottom Line: Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy.A majority (n=62) underwent aortic valve replacement, with fewer undergoing coronary artery bypass grafting (n=34) or mitral valve replacement/repair (n=24).PAOs are frequently detected in human atrium, where their presence is associated with clinical hypertension.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (T.N.S., L.C.M., L.V.Y., J.K.P., N.J.B., J.V.B., K.T.M.).

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Median and individual green/red ratio (G/R) values for all patient samples. For each patient sample (x axis), the range (vertical bars), median (black horizontal bars), and SD (dotted lines) of the individual imaging field G/R values (y axis) are illustrated. Whiskers are absent for data sets in which the 25% or 75% quantiles are equal or close to the median value. Data for patients with hypertension are shown in red, while blue indicates no history of hypertension.
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fig02: Median and individual green/red ratio (G/R) values for all patient samples. For each patient sample (x axis), the range (vertical bars), median (black horizontal bars), and SD (dotted lines) of the individual imaging field G/R values (y axis) are illustrated. Whiskers are absent for data sets in which the 25% or 75% quantiles are equal or close to the median value. Data for patients with hypertension are shown in red, while blue indicates no history of hypertension.

Mentions: For G/R values, data from different patients were assumed to be statistically independent, whereas those within a patient were correlated. Data inspection revealed that the individual field G/R values of the 92 patients did not have homogeneous variance (Figure 2). Therefore, we used a linear mixed‐effects model with random effect of study subject to handle the heterogeneity of variances within a patient. The correlation structure was based on the compound symmetry structure. The focus of the multivariable data analysis was to study the potential association between PAO burden, expressed as G/R values, and specific clinical variables, including age, sex, hypertension, body mass index, β‐blocker therapy, atrial source, and cardiac substrate (specifically aortic valve [AV] replacement). The general linear model analysis was used to study the correlation between G/R values and percent fibrosis. The statistical tests for model parameters were 2‐sided with a statistically significant level of .05. All statistical analysis was performed using R nlme package with version 2.14.1 for Windows.


Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?

Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT - J Am Heart Assoc (2014)

Median and individual green/red ratio (G/R) values for all patient samples. For each patient sample (x axis), the range (vertical bars), median (black horizontal bars), and SD (dotted lines) of the individual imaging field G/R values (y axis) are illustrated. Whiskers are absent for data sets in which the 25% or 75% quantiles are equal or close to the median value. Data for patients with hypertension are shown in red, while blue indicates no history of hypertension.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4338732&req=5

fig02: Median and individual green/red ratio (G/R) values for all patient samples. For each patient sample (x axis), the range (vertical bars), median (black horizontal bars), and SD (dotted lines) of the individual imaging field G/R values (y axis) are illustrated. Whiskers are absent for data sets in which the 25% or 75% quantiles are equal or close to the median value. Data for patients with hypertension are shown in red, while blue indicates no history of hypertension.
Mentions: For G/R values, data from different patients were assumed to be statistically independent, whereas those within a patient were correlated. Data inspection revealed that the individual field G/R values of the 92 patients did not have homogeneous variance (Figure 2). Therefore, we used a linear mixed‐effects model with random effect of study subject to handle the heterogeneity of variances within a patient. The correlation structure was based on the compound symmetry structure. The focus of the multivariable data analysis was to study the potential association between PAO burden, expressed as G/R values, and specific clinical variables, including age, sex, hypertension, body mass index, β‐blocker therapy, atrial source, and cardiac substrate (specifically aortic valve [AV] replacement). The general linear model analysis was used to study the correlation between G/R values and percent fibrosis. The statistical tests for model parameters were 2‐sided with a statistically significant level of .05. All statistical analysis was performed using R nlme package with version 2.14.1 for Windows.

Bottom Line: Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy.A majority (n=62) underwent aortic valve replacement, with fewer undergoing coronary artery bypass grafting (n=34) or mitral valve replacement/repair (n=24).PAOs are frequently detected in human atrium, where their presence is associated with clinical hypertension.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (T.N.S., L.C.M., L.V.Y., J.K.P., N.J.B., J.V.B., K.T.M.).

Show MeSH
Related in: MedlinePlus